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PODCAST

Hope & Histamine: The Paediatric Allergy Podcast

Goodlife Creations

“Helping you understand allergies—one episode at a time”Welcome to Hope & Histamine, the trusted podcast for families navigating the complex world of paediatric allergies. Hosted by a dedicated healthcare professional, this show offers clear, compassionate, and evidence-based guidance on the diagnosis, treatment, and day-to-day management of allergies and atopic conditions in children.From eczema to food allergies, asthma to anaphylaxis, each episode breaks down medical facts into practical

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All Episodes

28:55

Basophil Activation Test (BAT): Accuracy,...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/11/15

In this episode, we dive deep into the Basophil Activation Test (BAT) — one of the most advanced tools in modern allergy diagnostics. Join us as we break down how BAT works, when to use it, and what the evidence really says about its accuracy in diagnosing IgE-mediated food allergy, drug allergy, and complex sensitisation patterns. You’ll learn: • How BAT compares with skin prick testing and specific IgE • The clinical value of basophil activation markers such as CD63 and CD203c • When BAT im...

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44:12

How Accurate Are Allergy Tests? Unpacking...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/11/10

How accurate are the tests we rely on to diagnose IgE-mediated food allergy? In this episode, we explore the science behind skin prick testing, serum-specific IgE, and oral food challenges, examining their sensitivity, specificity, predictive values, and real-world limitations. Join us as we separate evidence from assumption, discussing false positives, cross-reactivity, and component-resolved diagnostics—and how to interpret results in the context of clinical history. Whether you’re a clinic...

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28:51

Decoding Component-Resolved Diagnostics: A New Era in...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/29

Component-Resolved Diagnostics (CRD) is transforming the way we diagnose and manage food and aeroallergy. In this episode, we break down what CRD really is, how molecular allergy testing works, and how it improves clinical decision-making beyond traditional IgE and skin prick testing. We explore: ✅ What CRD is and when to use it✅ Benefits of molecular allergen testing over extract-based testing✅ Clinical interpretation of key allergen components (Ara h 2, Cor a 9, Fel d 1 and more)✅ Risk stra...

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29:41

Peach Allergy Explained: Hidden Risks Behind a Summer...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/21

Peach allergy is more common than most people realise—especially in Europe and among people with seasonal hay fever or birch pollen allergy. In this episode, we unpack everything you need to know about peach allergy, including oral allergy syndrome (OAS) and lipid transfer protein (LTP) allergy, two very different immune responses linked to peach sensitivity. We explore: ✅ Why some people get an itchy mouth from peaches ✅ When a peach allergy can cause anaphylaxis ✅ Practical advice for diagn...

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36:39

Lipid Transfer Protein Allergy Explained: From...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/14

In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the complex world of Lipid Transfer Protein (LTP) allergy — a powerful plant food allergen that can cause severe and unexpected allergic reactions. Join us as we unpack how LTP allergy differs from pollen-related food syndromes, why it’s often seen in Mediterranean populations, and what clinicians, families, and patients need to know about cross-reactivity, diagnosis, and management. You’ll learn about: 🌿

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16:10

From Birch to Bite: The Hidden Allergy of Pollen Food...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/09

Have you ever wondered why some people get an itchy mouth or tingling lips after eating fresh fruit, vegetables, or nuts—especially during pollen season? In this episode of Hope & Histamine, we uncover the fascinating connection between pollen and food allergies, known as Pollen Food Allergy Syndrome (PFAS) or Oral Allergy Syndrome. Join us as we explore how pollen proteins “cross-react” with certain plant foods, why birch and grass pollens are the usual culprits, and what symptoms parent...

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13:31

When Beans Bite Back: Everything You Need to Know...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/04

Did you know that allergies to beans, peas, lentils and chickpeas are becoming more common? In this episode, we explain what a legume allergy really means, why some people with peanut allergy react to other legumes, and how to read food labels safely. We explore the science and clinical nuances of legume allergy, from immunological cross-reactivity and diagnostic challenges to practical dietary management and allergen labelling under UK and EU regulations. We also provide practical tips...

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14:53

Living With Soya Allergy: Hidden Ingredients, Soya...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/10/01

Soya is one of the 14 major allergens, but it often hides in unexpected places. In this episode, we explore the world of soya allergy, uncovering the role of soya lecithin in foods, and what allergen labelling laws really mean for patients, families, and healthcare professionals. We’ll discuss the difference between soya protein and soya derivatives, why some people react to trace amounts, and how manufacturers handle precautionary allergen labelling. Whether you’re living with a soya allergy...

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14:56

Beyond Typical: Understanding Atypical FPIES and Its...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/09/27

Beyond the Usual: Exploring Atypical FPIES takes you inside the complex world of Food Protein-Induced Enterocolitis Syndrome (FPIES)—a rare but increasingly recognised form of food allergy. This podcast unpacks the science, clinical challenges, and lived experiences surrounding atypical FPIES, where allergic mechanisms blur the line between classic FPIES and IgE-mediated food allergy. Whether you’re a healthcare professional, researcher, or parent navigating FPIES, this podcast offers clear, ...

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26:09

FPIES Uncovered: Demystifying Food Protein-Induced...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/09/15

Food Protein-Induced Enterocolitis Syndrome (FPIES) can be overwhelming for parents and healthcare professionals alike. In this episode, we break down everything you need to know about FPIES — from understanding the symptoms and triggers to exploring the latest research, diagnosis strategies, and treatment options. Featuring expert insights and practical tips, this podcast is your go-to resource for navigating FPIES with confidence. Whether you’re a parent, paediatrician, allergist, or ...

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26:34

Beyond the EpiPen: Debunking Anaphylaxis Myths and...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/09/03

Anaphylaxis remains one of the most critical emergencies in allergy care, yet myths, misconceptions, and inconsistent guidelines often leave both clinicians and patients confused. In this episode, we cut through the noise to explore the truth behind anaphylaxis management, debunk common myths about epinephrine use, and highlight key differences across major guidelines from organisations like BSACI, EAACI, AAAAI, and NICE. Join us as we bring in expert insights, real-world case studies, and ev...

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21:43

Anaphylaxis Unpacked: Recognition & Response

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/08/25

Anaphylaxis is a life-threatening medical emergency that can strike suddenly and escalate within minutes. In this episode, we unpack the essentials of recognising, treating, and preventing anaphylaxis. From the first warning signs and the crucial role of adrenaline to long-term care and patient education, we explore practical strategies that every healthcare professional, parent, and patient should know. Drawing on current guidelines and real-world clinical insights, this episode aims t...

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14:48

From Risk to Resilience: The IMPACT Peanut Study

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/08/13

Peanut allergy can make everyday life stressful — from birthday parties to school snacks. But what if there was a way to help children build protection instead of just avoiding peanuts altogether? In this episode, we dive into the Immune Tolerance Network IMPACT trial, a groundbreaking study testing whether tiny, carefully measured doses of peanut protein could help young children live with less fear and more freedom. We’ll break down what the research found, what it means for families ...

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10:46

Double Trouble: Unpacking Nut and Sesame Seed...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/08/06

In this episode, we dive into a groundbreaking European multicenter study that sheds light on the often-overlooked overlap between nut and sesame seed allergies. Why do so many children allergic to tree nuts also react to sesame? How can we accurately diagnose and define coexistent allergies through challenge-proven testing? Join us as we unpack the methodology, clinical significance, and real-world implications of this important research. Whether you’re a clinician, researcher, or allergy-aw...

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18:39

Peanuts, Pills, and Progress: The AR101 Breakthrough

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/08/02

In this episode, we dive into the fascinating world of oral immunotherapy (OIT) and explore the efficacy and safety of AR101 (now known as PTAH)—a groundbreaking treatment designed to reduce the risk of severe allergic reactions in children and adolescents with peanut allergy. We unpack the science behind this novel therapy, discuss key clinical trial findings (including the pivotal PALISADE study), and explore what AR101 means for families living with the daily anxiety of accidental peanut e...

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24:49

Nutty About Allergies: The Peanut Problem

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/07/29

Peanuts – love them or fear them, they sure know how to cause a stir. In this episode, we’re diving into the nutty world of peanut allergy—why it happens, how to spot it, and what you can do if you or your child has it. We’ll bust some common myths, chat about how early peanut introduction might actually help prevent allergies (yep, really!), and hear real-life stories from families living with peanut allergy every day. Plus, we’ll talk about what to do in an emergency and what new treatments...

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10:52

Peanut Allergy Prevention: Does Early Exposure Stick?...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/07/28

In this episode, we explore the groundbreaking LEAP-ON and LEAP-TRIO studies — follow-ups to the landmark LEAP trial that showed early peanut introduction in infants at high risk for allergy can dramatically reduce the development of peanut allergy. But does the benefit last if peanuts are later avoided? Join us as we unpack the latest research on the durability of early allergen exposure, why it matters for families and clinicians, and what it means for allergy prevention strategies wo...

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14:54

LEAP of Faith: How Early Peanuts Changed Allergy...

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/07/19

In this episode, we dive into the groundbreaking LEAP (Learning Early About Peanut Allergy) study, which transformed how we understand — and prevent — peanut allergy in children. We explore the science behind early peanut introduction, the study’s design and results, and what it means for parents, clinicians, and public health. Join us as we unpack the evidence, bust common myths, and discuss the future of allergy prevention. Sources: Du Toit, G., Roberts, G., Sayre, P.H., Bahnson, H.T., Radu...

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21:25

Skin, Food, Lungs: Unpacking the Atopic March

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/07/12

Unpacking the Atopic March is your go-to podcast for exploring how allergies unfold across childhood. From babyhood eczema and food allergies to school-age asthma and hay fever, we break down the science behind why allergic conditions seem to follow one another — a phenomenon known as the atopic march. Join us as we unpack the latest research, hear from leading allergy experts, and share real-life stories from families navigating these conditions. We’ll explore key questions like: Why do some...

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18:18

Tasting Tolerance: The EAT Study Uncovered

Hope & Histamine: The Paediatric Allergy Podcast ·

2025/06/30

What if the key to preventing food allergies lies in what – and when – we feed our babies? In this episode, we dive into the groundbreaking Enquiring About Tolerance (EAT) study, a landmark trial that challenged long-held beliefs about infant feeding and allergy prevention. Join us as we explore how introducing allergenic foods early – including peanut, egg, and dairy – may influence the development of food tolerance in infants. We’ll unpack the science, discuss what the findings mean for fam...

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