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PODCAST

Translating Proteomics

Nautilus Biotechnology

‘Translating Proteomics’ explores the science of proteomics and its growing impact on biological research, biomarker discovery, drug development, food and energy security, and a range of other timely topics. Hosts Parag Mallick Ph.D. and Andreas Huhmer Ph.D. of Nautilus Biotechnology aim to share their perspectives on important issues in proteomics, deepen your love of science, and prompt you to question assumptions about what may be possible.

science life sciences

All Episodes

46:20

“Ask me anything” with Parag Mallick, Andreas Huhmer,...

Translating Proteomics ·

2025/07/15

On this episode of Translating Proteomics, Parag, Andreas, and special guest Don Kirkpatrick answer questions submitted by the Translating Proteomics community. They cover:Needs in plasma proteomicsHow proteomics impacts drug development – with special guest Don Kirkpatrick, Ph.D.!How lifestyle impacts the proteomeHow the Nautilus Proteome Analysis Platform is impacting tau and Alzheimer’s disease researchReferencesShome et al., 2022 - Serum autoantibodyome reveals that healthy individuals share

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57:02

Spatial Proteomics with Fiona Ginty Ph.D.

Translating Proteomics ·

2025/05/28

On this episode of Translating Proteomics, host Parag Mallick discusses spatial proteomics with special guest Fiona Ginty Ph.D. Fiona is a Senior Principal Scientist in Precision Diagnostics at the GE Healthcare Technology & Innovation Center. She is a leader in the development of spatial proteomics technologies and their application in precision diagnostics and medicine.Their discussion covers:·How Fiona began working in spatial proteomics·Why spatial biology is important·What the future holds

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14:45

Intro to Proteomics

Translating Proteomics ·

2025/04/16

On this special episode of Translating Proteomics, Parag and Andreas break down the basics of proteomics — perfect for anyone with a background in molecular biology looking to get started in the field.Seasoned experts: We hope you can share this episode as a teaching tool or to inspire others to explore proteomics.Parag and Andreas cover the following questions in the episode, and links to additional Nautilus resources can be found below each question.What is proteomics?Blog post –What is

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48:07

Proteomics Podcast Crossover - The Proteomics Show

Translating Proteomics ·

2025/04/02

If you listened to our episode focused on science communication featuring proteomics leaders Ben Orsburn Ph.D. and Ben Neely Ph.D., then you've already heard about their excellent podcast, The Proteomics Show. On The Proteomics Show, they interview researchers in the proteomics community to learn about their motivations, their backstories, and their work. Today, we're sharing an episode of The Proteomics Show where the Bens interview Translating Proteomics host Parag Mallick. Check it out to learn

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20:49

US HUPO 2025 - Key Takeaways, Trends, and Future...

Translating Proteomics ·

2025/03/26

On this episode of Translating Proteomics, hosts Parag Mallick and Andreas Huhmer discuss their recent experience at the 2025 US Human Proteome Organization conference or US HUPO. Their conversation covers:·The rising use of multiple proteomics platforms·Advances in multiomicsAnd·What they hope to see at the next US HUPOChapters:00:00 – Introduction01:47 – Things Parag and Andreas were most excited about going into US HUPO06:19 - Trends Parag observed at US HUPO·A bifurcation between studies that

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49:15

Science Communication and Proteomics - Benefits,...

Translating Proteomics ·

2025/02/19

On this episode of Translating Proteomics, host Parag Mallick speaks with special guests doctors Ben Neely and Ben Orsburn, leaders in the proteomics community and hosts of “The Proteomics Show” podcast. Their insightful conversation focuses on the role of communication in proteomics and covers:·Impactful things they’ve learned while hosting The Proteomics Show·How their communication efforts have changed their research·Barriers to proteomics becoming more popular in the life sciences and in the

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35:23

The Future of Food in a Proteomics World

Translating Proteomics ·

2025/02/05

On this episode of Translating Proteomics, hosts Parag Mallick and Andreas Huhmer discuss the many ways proteomics can impact our interactions with food. Some of the topics they touch upon in this wide-ranging conversation include:·Proteomics and food quality·Proteomics and food safety·Developing new kinds of food with proteomicsChapters00:00 – 01:23 – Introduction01:23 – 03:27 – Proteomics and alcohol fermentation03:27 – 05:24 – Food properties and their relationship with molecular composition05:24

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28:48

Combating the Reproducibility Crisis in Computational...

Translating Proteomics ·

2025/01/22

On this episode of Translating Proteomics, co-hosts Parag Mallick and Andreas Huhmer of NautilusBiotechnology discuss the reproducibility crisis in biology and specifically focus on how we can enhance reproducibility in computational proteomics. Key topics they cover include:•What the reproducibility crisis is•Factors that make it difficult to replicate multiomics research•Steps we can take to make biology research more reproducibleChapters00:00 – 01:20 – Introduction01:20– 03:10 – What is

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30:18

Expanding the Drug Development Toolkit with Proteomics

Translating Proteomics ·

2025/01/09

On this episode of Translating Proteomics, co-hosts Parag Mallick and Andreas Huhmer of Nautilus Biotechnology discuss how clinical researchers can leverage proteomics for drug development. Some of the themes covered in this episode include:·Proteomics and pre-clinical models·How proteomics can drive patient selection·Choosing the right end points in clinical trialsChapters00:00 – 01:06 – Introduction01:06 – 06:51 – Proteomics in pre-clinical studies06:51 – 11:40 – The importance of choosing the

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51:51

2024 Year-End Special: 3 Exciting Examples of...

Translating Proteomics ·

2024/12/18

On this special, year-end episode of Translating Proteomics, hosts Parag Mallick and Andreas Huhmer discuss three of their favorite proteomics publications from 2024. They'll cover one paper in each of the following topic areas:Proteomics in pre-clinical researchProteomics in basic researchTechnology development in proteomicsSynopses of each of the papers can be found below and you can find many more insights in the podcast.Decrypting the molecular basis of cellular drug phenotypes by dose-resolved

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53:59

AI and Biotech - The Promise and the Pitfalls with...

Translating Proteomics ·

2024/12/04

Parag Mallick discusses the role of AI and machine learning in biotech with special guests Vijay Pande from Andreessen Horowitz and Matt McIlwain from Madrona Venture Group. Their fascinating conversation covers:Advances that have enabled biotech to make use of AI and machine learningHow founders are applying AI and machine learning in biotechThe future of AI and machine learning in biotechChapters00:00 - Introduction04:37 - How did Vijay and Matt get into AI and ML07:33 - The importance of

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42:09

A New Era In Alzheimer's Research with Sarah DeVos

Translating Proteomics ·

2024/10/30

Do you have a question you'd like answered on a future episode of Translating Proteomics? Send it to translatingproteomics@nautilus.bio!On this episode of Translating Proteomics, host Andreas Huhmer discusses advances in Alzheimer’s research with special guest and Curie Bio Drug Maker in Residence, Sarah DeVos Ph.D. Their conversation focuses on:The impact of molecular diagnostics on Alzheimer’s researchRecent Alzheimer’s drug approvalsThe future of Alzheimer’s research*Small edit on Sarah's

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29:25

Plasma Proteomics - The Dream and the Nightmare

Translating Proteomics ·

2024/10/28

On this episode of Translating Proteomics, hosts Parag Mallick and Andreas Huhmer of Nautilus Biotechnology discuss the challenges and opportunities of plasma proteomics. Their conversation focuses on:·Why blood plasma may be a good source of protein biomarkers·Current methodologies and pitfalls in plasma proteomics·The path forward for plasma proteomicsWhat is Plasma Proteomics?For those who are new to this topic,plasmais the liquid portion of the blood distinct from fractions containing red and

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45:40

Protein Function 201 with Kathryn Lilley

Translating Proteomics ·

2024/10/17

Proteins adopt a wide variety of functions depending upon factors like their location in the cell, their modifications, and the biomolecules they interact with. While many of us may have been taught that single genes produce single proteins that have single functions, protein function is far more dynamic than that. In this episode of Translating Proteomics, Nautilus Co-Founder and Chief Scientist Parag Mallick sits down with University of Cambridge Professor and proteomics expert Kathryn Lilley to

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47:35

Are Proteins A Myth? With Special Guest Professor...

Translating Proteomics ·

2024/10/03

In our Translating Proteomics episode titled "Harnessing Proteoforms to Understand Life's Complexity", Parag and Andreas discussed whyproteoformsare important in a theoretical sense. In this episode, Parag sits down with Northwestern University Professor and proteoform pioneer,Neil Kelleherto dive deep into the biology of proteoforms. They cover:What proteoforms areExamples of the importance of proteoformsThe scale of and technological advances needed to meet the challenges of proteoform

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26:22

Expanding the Druggable Universe with Proteomics

Translating Proteomics ·

2024/06/26

Despite incredible leaps in our understanding of molecular biology, the majority of drug development efforts still fail, and those that succeed often fail to return investment dollars. Proteomics has the potential to change that by providing high-resolution views of the biochemical drivers of biological function - proteins. In this episode of Translating Proteomics, Parag and Andreas discuss how proteomics can help researchers identify good drug targets, personalize drug development, and advance

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24:34

Harnessing Proteoforms to Understand Life's Complexity

Translating Proteomics ·

2024/06/19

Proteins are far more than just the output of genes. They can be modified in myriad ways to produce millions ofproteoformswith altered dynamics, localization, and function. For a comprehensive understanding of biology that will propeldrug developmentandbiomarker discoveryforward, we need to be able to measure proteoforms routinely. In this episode, Parag and Andreas discuss the incredible value that will come from studying proteoforms and describe what it will take to make proteoform measurement a

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24:44

The Future of AI in Biomedicine

Translating Proteomics ·

2024/06/05

AI might be the biggest buzz word of the decade, but the buzz is warranted in terms of its practical potential in biological research. In this episode of Translating Proteomics, Parag and Andreas discuss some of the early wins for AI in biology, practical ways AI can be applied to biology research in the near term, challenges in that application, and how proteomics researchers in particular can use AI to advance their work.Chapters:00:00 – Why now is the time to apply AI to biomedicine05:28 –

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17:37

Why the Dogma around Biology's Central Dogma Is Wrong

Translating Proteomics ·

2024/05/22

From high school biology on up, we're taught the central dogma of biology - that biological information flows from DNA to RNA to proteins. This representation of the central dogma is, however, very much a simplification of its original formulation by Francis Crick and over-applying it can lead us down spurious paths and faulty conclusions. In this episode of Translating Proteomics, Parag and Andreas dive into the real meaning of the central dogma and discuss how modern biology research, including

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21:53

Single-protein Biomarkers Don't Cut It

Translating Proteomics ·

2024/05/08

Protein biomarkers are proteins measured as indicators of biological processes. People often hope biomarkers will take the form of elevated or decreased amounts of single proteins, but few single protein measurements provide specific and sensitive indications of biological processes. In this episode of Translating Proteomics, Parag and Andreas discuss why it is difficult to find new biomarkers and describe how new techniques can enable the development of multi-protein, multi-time point, and even

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23 results

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