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PODCAST

Docs Who Lift

Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.

health & fitness medicine

All Episodes

00:49:39

Menopause, Muscle, and the Myths | Dr. Alyssa Olenick

Docs Who Lift ·

2026/03/13

Dr. Spencer and Karl Nadolsky bring on Dr. Alyssa Olenick, exercise physiologist and postdoctoral researcher in menopause and metabolism, to cut through the noise on one of the most misrepresented topics in women's health.Dr. Olenick holds a PhD in exercise physiology, completed postdoctoral training focused on menopause and body composition, and is the founder of the Liss Method, a hybrid training program combining strength and endurance. She has been doing women-specific and sex-difference

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00:35:06

The Truth About Creatine (Doctors Discuss)

Docs Who Lift ·

2026/03/06

Takeaways:Creatine is a naturally occurring compound that helps regenerate ATP, the energy currency of the cell. Supplementing with creatine can enhance performance in high-intensity exercise but may not be beneficial for endurance activities. The majority of creatine is stored in muscle, and supplementation can help fill those stores for better energy availability. Creatine monohydrate is the most studied and effective form of creatine, and it's also the cheapest. There is no need to cycle

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00:48:33

Top Sleep Doctor: Stop Taking Melatonin Like This

Docs Who Lift ·

2026/02/23

Takeaways:The 11-Minute Rule: Why blue light isn't the villain you think it is.The Melatonin Mistake: Why "less is more" (and the exact dosage for success). Trackers vs. Reality: When to throw away your Apple Watch or Oura Ring. The Bedrock Principle: Why sleep is the lead domino for fat loss and metabolic health. Sex & Sleep: The surprising biological difference in how men and women recover. Tap Here to follow ShelbyShelbys Book Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for

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00:54:19

GLP-1s and Fertility What to Know Before Trying to...

Docs Who Lift ·

2026/02/12

Get The Lucky Egg Book HereTakeaways:Dr. Lucky Sekhon is a reproductive endocrinologist and author of 'The Lucky Egg'.The pathway to reproductive endocrinology involves extensive training in OB-GYN and specialized fellowship.Social media became a tool for Dr. Sekhon to combat misinformation during the pandemic.Common myths in fertility include the idea that one can reverse the biological clock.Understanding the fertility knowledge gap is crucial for patients seeking help.Insulin resistance plays a

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00:45:13

Reclaiming Excellence: A Conversation with Brad Stulberg

Docs Who Lift ·

2026/01/30

TakeawaysExcellence is not a standard but a process of becoming.Involved engagement means caring deeply about what you do.The pursuit of excellence shapes you into a better person.Consistency is key to achieving long-term goals.It's important to align your pursuits with your values.Youth sports can be beneficial but also harmful if not approached correctly.Weight loss should shift from a focus on numbers to health and well-being.Building a diverse identity can help prevent burnout in athletes.The

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00:25:23

Oral GLP-1 (Wegovy) Is Here: Dosing, Switching, and...

Docs Who Lift ·

2026/01/20

Key Episode TakeawaysOral Wegovy is real, but it’s not “just a pill version of the shot.” Absorption rules, dosing schedules, and patient selection matter a lot more than most headlines suggest.Switching from injections to oral GLP-1s requires a plan. The transition isn’t one-size-fits-all, and dose timing, GI tolerance, and expectations need to be managed carefully.Weight regain after stopping GLP-1s is common, but not universal. SURMOUNT-4 data shows large variability, reinforcing that biology,

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00:29:55

Breaking Down the New Food Pyramid (Great or Confusing)

Docs Who Lift ·

2026/01/12

Takeaways:Dietary guidelines have evolved since the 1980s.The food pyramid was introduced in 1992 and has influenced public perception.New dietary guidelines emphasize healthy fats but retain some old recommendations.There are contradictions in the new guidelines regarding saturated fat and protein intake.The definition of processed foods remains vague and controversial.The guidelines are intended for healthcare professionals, not consumers.Public policy needs to align with dietary guidelines for

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01:03:28

Cortisol Myths vs Reality: What Your Adrenals...

Docs Who Lift ·

2026/01/07

Takeaways:Cortisol is essential for various bodily functions, especially during stress.Adrenal glands have a circadian rhythm that affects cortisol production.Cushing's syndrome can result from excess cortisol and has specific symptoms.Diagnosis of adrenal disorders requires careful testing and consideration of symptoms.Mild autonomous cortisol secretion can complicate diabetes management.The Catalyst trial explored the effects of cortisol antagonism on diabetes.Future research may focus on

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00:31:54

GLP-1 Side Effects Deep Dive: Slimmer's Paralysis,...

Docs Who Lift ·

2025/12/05

Takeaways:Slimmer's Paralysis is a recognized condition.Ethical boundaries are crucial in patient relationships.Medical professionals must maintain professionalism at all times.Humor can sometimes arise in serious discussions.Patient stories should always be handled with care.The importance of clear communication in medical settings.Understanding patient experiences is vital for effective care.Ethics in medicine is a complex and nuanced topic.Medical discussions can lead to unexpected

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00:34:08

GLP-1s and Breast Milk: What the New Research...

Docs Who Lift ·

2025/11/19

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential

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00:35:23

How to Build Healthy Routines That Actually Stick

Docs Who Lift ·

2025/11/12

Takeaways:Behavior change is a complex process that requires understanding motivation and discipline.Motivation is not just a feeling; it's a psychological skill that can be developed.Many common phrases about behavior change are misleading and oversimplified.Exercise should be viewed as a choice rather than a habit that becomes automatic.Self-efficacy is crucial for successful behavior change and can be built through mastery experiences.Future self thinking can help individuals align their actions

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01:00:56

The Truth About Testosterone Therapy in Women (with...

Docs Who Lift ·

2025/11/03

Testosterone therapy can improve libido in postmenopausal women.Sexual dysfunction in women is complex and multifactorial.Low sexual desire is only considered a disorder if it causes distress.Psychosocial factors play a significant role in sexual health.Testosterone levels do not change significantly at menopause.The placebo effect can significantly influence treatment outcomes.Individualized care is crucial in managing sexual dysfunction.Dosing for testosterone therapy should be carefully

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00:32:01

From Injections to Pills: Breaking Down the New Oral...

Docs Who Lift ·

2025/10/23

Show Notes:In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe

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00:48:03

De-Emphasizing BMI, Prioritizing Health: What’s New...

Docs Who Lift ·

2025/10/13

In this episode of Docs Who Lift, the Nadolsky brothers dive deep into the newly released American Association of Clinical Endocrinology (ACE) Algorithm for Obesity Care led by Dr. Karl himself. They explore:Why ACE moved away from a BMI-only approach to a person-centered, complication-centric modelThe new staging framework (ABCD) that helps individualize treatment intensityHow to interpret “clinical” vs “preclinical” obesity under the new modelUpdated targets for clinically meaningful weight loss

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00:57:56

Debunking The Myths of Metabolism and Weight Loss

Docs Who Lift ·

2025/09/25

TakeawaysThe book aims to dispel myths surrounding the Biggest Loser study.Miscommunication in media has led to public confusion about metabolism.Metabolic adaptation is a response to weight loss, not a determinant of it.Cultural factors significantly influence eating habits and food choices.The food environment plays a crucial role in dietary behaviors.Bipartisan support is necessary for effective food policy changes.Understanding metabolism requires a nuanced approach beyond just calories.The

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00:39:26

Menopause Medicine Meets Obesity Care: Doctors React

Docs Who Lift ·

2025/09/01

Takeaways Menopausal women often prioritize weight gain concerns over other symptoms.The study observed an association between hormone therapy and weight loss with GLP-1 medications.Retrospective studies have limitations but can provide valuable insights.Future research should focus on randomized controlled trials to confirm findings.The relationship between estrogen and GLP-1 signaling needs further exploration.Funding for research can be challenging, especially for early career

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01:07:13

Women’s Fitness Needs Debate: Dr. Stacy Sims vs. Dr....

Docs Who Lift ·

2025/08/29

We covered:Fasted trainingProtein timingand many more fitness topics!Hear Dr. Lauren Colenso-Semple and Dr. Stacy Sims discuss outcomes versus mechanisms and much moreTap Here for Dr Stacy Sims ReferencesTap Here for Dr. Colenso-Semples ReferencesDr. LCS InstagramDr. SS Instagram

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00:33:50

Do You Really Lose Muscle on Semaglutide or Tirzepatide?

Docs Who Lift ·

2025/08/22

TakeawaysThe podcast features Dr. Grant Tinsley, a body composition expert.The discussion revolves around a case series on body composition effects.GLP-1 receptor agonists are a focus of the research.The importance of resistance training in weight loss is emphasized.Patient case studies provide insights into individual experiences.The first patient lost a significant amount of fat mass while preserving lean mass.The second patient achieved remarkable body composition changes in a short time.The

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00:49:50

Predatory Lab Testing: What They’re Not Telling You

Docs Who Lift ·

2025/08/16

TakeawaysDirect-to-consumer lab testing is on the rise, with significant marketing efforts behind it.Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.Over-testing can lead to unnecessary anxiety and misinterpretation of results.Fitness influencers often promote lab testing without proper medical training, which

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00:20:12

CVS Pulled the Plug on Zepbound?!

Docs Who Lift ·

2025/08/08

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access to effective obesity treatments. The conversation highlights the

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