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PODCAST

Docs Who Lift

Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.

health & fitness medicine

All Episodes

00:31:54

GLP-1 Side Effects Deep Dive: Slimmer's Paralysis,...

Docs Who Lift ·

2025/12/05

Takeaways:Slimmer's Paralysis is a recognized condition.Ethical boundaries are crucial in patient relationships.Medical professionals must maintain professionalism at all times.Humor can sometimes arise in serious discussions.Patient stories should always be handled with care.The importance of clear communication in medical settings.Understanding patient experiences is vital for effective care.Ethics in medicine is a complex and nuanced topic.Medical discussions can lead to unexpected

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00:34:08

GLP-1s and Breast Milk: What the New Research...

Docs Who Lift ·

2025/11/19

Takeaways:Drug transfer during lactation is complex and challenging.Semaglutide was not detected in women taking any dose.Low amounts of tears epitide were found in milk.Tissue damage can affect drug absorption.Mastitis and engorgement complicate the lactation process.Injections are necessary for effective drug delivery.The analogy of an elephant illustrates the difficulty of drug transfer.Detection of drugs in milk is a critical concern for breastfeeding mothers.Understanding turnover is essential

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00:35:23

How to Build Healthy Routines That Actually Stick

Docs Who Lift ·

2025/11/12

Takeaways:Behavior change is a complex process that requires understanding motivation and discipline.Motivation is not just a feeling; it's a psychological skill that can be developed.Many common phrases about behavior change are misleading and oversimplified.Exercise should be viewed as a choice rather than a habit that becomes automatic.Self-efficacy is crucial for successful behavior change and can be built through mastery experiences.Future self thinking can help individuals align their actions

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01:00:56

The Truth About Testosterone Therapy in Women (with...

Docs Who Lift ·

2025/11/03

Testosterone therapy can improve libido in postmenopausal women.Sexual dysfunction in women is complex and multifactorial.Low sexual desire is only considered a disorder if it causes distress.Psychosocial factors play a significant role in sexual health.Testosterone levels do not change significantly at menopause.The placebo effect can significantly influence treatment outcomes.Individualized care is crucial in managing sexual dysfunction.Dosing for testosterone therapy should be carefully

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00:32:01

From Injections to Pills: Breaking Down the New Oral...

Docs Who Lift ·

2025/10/23

Show Notes:In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe

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00:48:03

De-Emphasizing BMI, Prioritizing Health: What’s New...

Docs Who Lift ·

2025/10/13

In this episode of Docs Who Lift, the Nadolsky brothers dive deep into the newly released American Association of Clinical Endocrinology (ACE) Algorithm for Obesity Care led by Dr. Karl himself. They explore:Why ACE moved away from a BMI-only approach to a person-centered, complication-centric modelThe new staging framework (ABCD) that helps individualize treatment intensityHow to interpret “clinical” vs “preclinical” obesity under the new modelUpdated targets for clinically meaningful weight loss

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00:57:56

Debunking The Myths of Metabolism and Weight Loss

Docs Who Lift ·

2025/09/25

TakeawaysThe book aims to dispel myths surrounding the Biggest Loser study.Miscommunication in media has led to public confusion about metabolism.Metabolic adaptation is a response to weight loss, not a determinant of it.Cultural factors significantly influence eating habits and food choices.The food environment plays a crucial role in dietary behaviors.Bipartisan support is necessary for effective food policy changes.Understanding metabolism requires a nuanced approach beyond just calories.The

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00:39:26

Menopause Medicine Meets Obesity Care: Doctors React

Docs Who Lift ·

2025/09/01

Takeaways Menopausal women often prioritize weight gain concerns over other symptoms.The study observed an association between hormone therapy and weight loss with GLP-1 medications.Retrospective studies have limitations but can provide valuable insights.Future research should focus on randomized controlled trials to confirm findings.The relationship between estrogen and GLP-1 signaling needs further exploration.Funding for research can be challenging, especially for early career

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01:07:13

Women’s Fitness Needs Debate: Dr. Stacy Sims vs. Dr....

Docs Who Lift ·

2025/08/29

We covered:Fasted trainingProtein timingand many more fitness topics!Hear Dr. Lauren Colenso-Semple and Dr. Stacy Sims discuss outcomes versus mechanisms and much moreTap Here for Dr Stacy Sims ReferencesTap Here for Dr. Colenso-Semples ReferencesDr. LCS InstagramDr. SS Instagram

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00:33:50

Do You Really Lose Muscle on Semaglutide or Tirzepatide?

Docs Who Lift ·

2025/08/22

TakeawaysThe podcast features Dr. Grant Tinsley, a body composition expert.The discussion revolves around a case series on body composition effects.GLP-1 receptor agonists are a focus of the research.The importance of resistance training in weight loss is emphasized.Patient case studies provide insights into individual experiences.The first patient lost a significant amount of fat mass while preserving lean mass.The second patient achieved remarkable body composition changes in a short time.The

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00:49:50

Predatory Lab Testing: What They’re Not Telling You

Docs Who Lift ·

2025/08/16

TakeawaysDirect-to-consumer lab testing is on the rise, with significant marketing efforts behind it.Many patients feel brushed off by traditional healthcare providers, leading them to seek alternative testing options.Communication between patients and healthcare providers is often inadequate, contributing to misunderstandings about health.Over-testing can lead to unnecessary anxiety and misinterpretation of results.Fitness influencers often promote lab testing without proper medical training, which

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00:20:12

CVS Pulled the Plug on Zepbound?!

Docs Who Lift ·

2025/08/08

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the recent changes in obesity medication coverage, particularly focusing on the CVS Caremark decision to drop ZEPBound from their formulary in favor of Wegovi. They explore the implications of this decision for patients and providers, the role of pharmacy benefit managers (PBMs) in healthcare, and the ongoing advocacy efforts to ensure access to effective obesity treatments. The conversation highlights the

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00:11:16

More Than Weight Loss? GLP-1s and Cardiovascular Risk

Docs Who Lift ·

2025/08/03

In this episode of the Dr. Lift podcast, hosts Dr. Spencer Nadolsky and Dr. Karl discuss the Surpass CVOT trial, which evaluates the cardiovascular outcomes of Monjaro compared to Dulaglutide (Trulicity). They delve into the significance of the trial, the implications of the results, and the potential benefits of Monjaro for patients with type 2 diabetes and cardiovascular risks. The conversation highlights the importance of understanding cardiovascular outcome trials and the evolving landscape of

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00:41:34

Semaglutide vs. Tirzepatide: Are We Closing the Gap?

Docs Who Lift ·

2025/07/24

How the STEP-UP trial came to life, and what made the 7.2mg dose possibleWhat the data actually says about weight loss and side effects at higher dosesWhy trial design, pharmacokinetics, and estimands matter more than you thinkWhat’s coming next in obesity meds: duals, triples, and even antagonistsThe real talk on intermittent fasting, access issues, and preaching vs. scienceSign up for Dr. Spencer''s Clinic

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00:31:36

Clinical vs Anthropometric Obesity

Docs Who Lift ·

2025/07/02

TakeawaysThe study examines the overlap between clinical and anthropometric obesity.Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.Challenges exist in applying the Lancet Commission's definitions in clinical practice.Metabolically healthy obesity is a debated topic in obesity research.The study highlights the importance of data from the All of Us Research Program.There is a significant prevalence of preclinical obesity in individuals with normal BMI.The

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00:33:33

GLP-1 meds and macular degeneration

Docs Who Lift ·

2025/06/23

Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article

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00:27:48

Menopause, MHT, and GLP-1 medicines

Docs Who Lift ·

2025/06/12

Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopauseWeight management in women is influenced by hormonal changes throughout life stages.Retrospective analyses can provide insights but have limitations.The wellness industry often oversimplifies complex medical issues.Hormonal replacement therapy may have subtle benefits for weight management.Confounding factors like SSRIs can complicate weight loss efforts.A holistic approach is essential for

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00:28:28

The Science of Myostatin inhibitors, GLP-1 meds and...

Docs Who Lift ·

2025/06/06

Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The

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00:56:22

Current State of Nutrition Research and MAHA

Docs Who Lift ·

2025/05/29

Takeaways:The MAHA report aims to address public health issues but lacks actionable policies.Historical context is crucial for understanding current dietary guidelines.Funding for nutrition research has been inadequate, impacting the quality of data.Public perception of nutrition often outpaces scientific evidence.The evolution of dietary guidelines reflects political and social influences.There is a need for more rigorous nutrition science to inform policy.The dietary guidelines have not

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00:46:48

Joy Prescriptions

Docs Who Lift ·

2025/05/13

Click to read Joy PrescriptionsDrs. Karl and Spencer talk to Dr. Tiffany Moon all about Joy Prescriptions. Learn how to stop chasing perfection and embrace connection. 00:00Introduction to Dr. Tiffany Moon02:02Journey to Reality TV: The Real Housewives of Dallas05:58Life After Reality TV: Finding Joy and Purpose09:59The Joy Prescription: A New Approach to Life17:01Work-Life Integration: Balancing Career and Family22:09Empowering Women: The Lead Her Summit22:33Tiffany's Journey: From Childhood to

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