JAMA Clinical Reviews

20:32

Narcolepsy: A Review

JAMA Clinical Reviews ·

2026/10/05

Narcolepsy is a chronic neurologic disorder that causes severe daytime sleepiness and impaired quality of life. Author Tom Scammell, MD, of Harvard Medical School joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the etiology, clinical presentation, diagnostic evaluation, and treatment of narcolepsy. Related Content: Narcolepsy The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

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14:02

Influenza, RSV, and COVID-19 Vaccines: Effectiveness,...

JAMA Clinical Reviews ·

2026/09/30

Respiratory virus vaccine effectiveness and safety for influenza, RSV, and COVID-19 are reviewed, including new evidence, risks, and recommendations. JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks with Rochelle Walensky, MD, MPH, professor of medicine at Harvard Medical School and former CDC Director, about vaccine data, public trust, and the 2026 respiratory virus season. Related Content: Respiratory Season Virus Vaccines RSV Immunization Effectiveness and Safety for the 2026-2027 Respiratory

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20:12

Vaccines for Cancer Treatment

JAMA Clinical Reviews ·

2026/09/21

Cancer vaccines stimulate immune cells to recognize proteins or mutations found on or within cancer cells, facilitating destruction of cancer cells. Several vaccines are approved and others are in development for cancer treatment. Author Nora Disis, MD, JAMA Deputy Editor and Editor in Chief of JAMA Oncology, discusses cancer vaccines and more with JAMA Deputy Editor Mary McDermott, MD. Related Content: Vaccines for Cancer

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19:14

Idiopathic Normal Pressure Hydrocephalus: Diagnosis...

JAMA Clinical Reviews ·

2026/09/14

Idiopathic normal pressure hydrocephalus (iNPH) affects approximately 1% to 4% of adults aged 65 years and older and is associated with gait impairment, cognitive decline, and urinary dysfunction. Author Mark G. Luciano, MD, PhD, from Johns Hopkins University, discusses this and more with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Idiopathic Normal Pressure Hydrocephalus

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23:15

Rheumatoid Arthritis

JAMA Clinical Reviews ·

2026/09/10

Rheumatoid arthritis can affect any synovial joint and cause irreversible damage, but early diagnosis and treatment with DMARDs can reduce inflammation and lower the risk of joint destruction. JAMA Associate Editor David Simel, MD, MHS, is joined by review coauthor Josef Smolen, MD, to discuss this topic. Related Content: Rheumatoid Arthritis in Adults

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28:43

An Overview of Postural Orthostatic Tachycardia...

JAMA Clinical Reviews ·

2026/08/24

POTS is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. Author Satish Raj, MD, MSCI, of University of Calgary Cumming School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the pathophysiology, diagnosis, and management of POTS. Related Content: Postural Orthostatic Tachycardia Syndrome (POTS)

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20:14

Medication Treatments for Alcohol Use Disorder

JAMA Clinical Reviews ·

2026/08/19

Naltrexone, acamprosate, disulfiram, and topiramate are effective but underused medications for treatment of alcohol use disorder. Author Stephen Holt, MD, MS, of Yale School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss first-line pharmacotherapy for alcohol use disorder and important safety, efficacy, and hospital initiation considerations. Related Content: Medications for Alcohol Use Disorder

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23:48

Liquid Biopsy Tests for Cancer

JAMA Clinical Reviews ·

2026/08/10

Circulating tumor DNA (ctDNA)(liquid biopsies) can help monitor cancer progression, detect residual cancer after treatment, and identify genetic changes within cancer cells that could affect treatment response. Author Ben Ho Park, MD, PhD, of the Vanderbilt-Ingram Cancer Center discusses current evidence regarding use of liquid biopsies in management of cancer with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: Liquid Biopsies for Cancer Applications of Liquid Biopsy for Surgical

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10:35

Patient-Clinician Communication About Physical Activity

JAMA Clinical Reviews ·

2026/08/06

Physical activity is an effective component of care for people with chronic medical conditions. In this podcast, JAMA Insights author Alessio Bricca, PhD, University of Southern Denmark, discusses adaptable methods to promote physical activity in patients with chronic medical conditions with host Anne Rentoumis Cappola, MD, ScM. Related Content: Communicating With Patients About Physical Activity

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20:59

Classic Hodgkin Lymphoma

JAMA Clinical Reviews ·

2026/08/03

Hodgkin lymphoma is a relatively rare disease, with approximately 82 409 incident cases reported globally in 2022, and 8720 cases reported in the US in 2025. Author Alison Moskowitz, MD, of Memorial Sloan Kettering Cancer Center joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss current evidence about the diagnosis and management of Hodgkin lymphoma in adults. Related Content: Classic Hodgkin Lymphoma

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13:59

The Sleep-Weight Connection

JAMA Clinical Reviews ·

2026/07/29

Suboptimal sleep quality and quantity are associated with higher body mass index and more difficulty losing weight. In this podcast, JAMA Insights author Atul Malhotra, MD, from the University of California, San Diego, discusses evidence regarding sleep and obesity with JAMA Deputy Editor Mary McDermott, MD. Related Content: Sleep Health and Obesity

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23:22

Management of Dyslipidemia

JAMA Clinical Reviews ·

2026/07/20

Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of global mortality and is strongly associated with cumulative exposure to atherogenic lipoproteins across the lifespan. Author Amber E. Johnson, MD, MS, MBA, of the University of Chicago joins JAMA Senior Editor Philip Greenland, MD, to discuss the ACC/AHA guideline on management of dyslipidemia. Related Content: Dyslipidemia Evaluation and Management Implications of the 2026 Dyslipidemia Guideline for Primary Prevention

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19:23

Hip Fractures: Management and Prevention

JAMA Clinical Reviews ·

2026/07/16

Hip fractures are a leading cause of disability and death in older adults. This episode summarizes risk factors, prevention, and medical and surgical management of hip fractures. JAMA Deputy Editor Mary M. McDermott, MD, interviews Douglas Kiel, MD, MPH, of Harvard Medical School and Marcus Institute for Aging Research. Related Content: Hip Fractures

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20:04

Alcohol-Related Liver Disease

JAMA Clinical Reviews ·

2026/07/06

Alcohol-related liver disease is the leading cause of liver-related morbidity and mortality and the most common indication for liver transplant in Europe and the US. Author Aleksander Krag, MD, PhD, of the University of Southern Denmark joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss a recent review on this topic published in JAMA. Related Content: Alcohol-Related Liver Disease

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10:25

An Overview of Familial Hypercholesterolemia

JAMA Clinical Reviews ·

2026/06/29

Worldwide, heterozygous familial hypercholesterolemia (FH) affects approximately 1 in 250 to 350 individuals. Author James Stein, MD, of the University of Wisconsin School of Medicine and Public Health joins JAMA Deputy Editor Karen Lasser, MD, MPH, to discuss the epidemiology, diagnosis, and treatment of both homozygous and heterozygous FH. Related Content: Familial Hypercholesterolemia

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15:39

Transforming Communication Between Patients and...

JAMA Clinical Reviews ·

2026/06/22

Patient portal messaging continues to expand across health systems, and it has become an increasingly important method for patient-clinician communication. Authors Michal Mankowski, PhD, assistant professor, and Jane Long, MD, research resident, both from the Department of Surgery at NYU, discuss their new research letter with JAMA Deputy Editor Joseph Ross, MD, MHS. Related Content: Trends in Patient Portal Messages, Office Visits, and Telephone Encounters National Trends in Patient Messaging—The

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26:10

Low Back Pain: Diagnosis and Treatment

JAMA Clinical Reviews ·

2026/06/15

Nonspecific low back pain is a leading cause of disability, with most cases lacking a clear anatomic cause. This episode reviews risk factors, diagnosis, and current evidence-based treatments for acute and chronic low back pain. JAMA Deputy Editor Mary M. McDermott, MD, interviews author James McAuley, PhD, of the University of New South Wales. Related Content: Low Back Pain What Is Low Back Pain?

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23:02

Survivors of Cyanotic Congenital Heart Disease

JAMA Clinical Reviews ·

2026/06/08

Cyanotic congenital heart diseases occur in approximately 0.2% of live births in the US, but survival to adulthood is common with current surgical interventions. JAMA Associate Editor David Simel, MD, MHS, speaks with author Michael Landzberg, MD, who coauthored a recent review in JAMA on this topic. Related Content: Survivors of Cyanotic Congenital Heart Disease

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16:54

Point-of-Care Ultrasound for the Diagnosis of...

JAMA Clinical Reviews ·

2026/06/03

Community-acquired pneumonia (CAP) accounts for 1.4 million emergency department visits and 740 000 hospitalizations annually in the US. Author Andre Kumar, MD, MEd, of Stanford University School of Medicine joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the use of point-of-care ultrasound for diagnosis of CAP. Related Content: Point-of-Care Ultrasound for the Diagnosis of Pneumonia Bedside Lung Ultrasound in Emergency (BLUE) for Evaluation of Dyspnea

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15:19

Cesarean Delivery on Request

JAMA Clinical Reviews ·

2026/05/27

Cesarean delivery on maternal request requires individualized counseling. Reduced risks of pelvic floor disorders should be weighed against surgical risks and future risks including abnormal placentation. Author Marianna Alperin, MD, MS, from UC San Diego School of Medicine, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD. Related Content: Cesarean Delivery on Maternal Request Cesarean Delivery—Reply Cesarean Delivery

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