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PODCAST

CrownCast

🎥Crown Bioscience

CrownCast, Crown Bioscience"s podcast aims to discuss the emerging trends, breakthroughs, and viewpoints in oncology drug discovery, and development.

science life sciences

All Episodes

26:21

Harnessing the Power of High-quality Biospecimens

CrownCast ·

2025/10/30

As cancer research progresses rapidly, obtaining high-quality biospecimens has grown increasingly important for making significant breakthroughs.In this CrownCast episode, Rajendra Kumari, Executive Director of Integrated Solutions at Crown Bioscience, talks with Sadaf Malik, Senior Director, Head US Sales (Biobank and Biomarker) about how superior biospecimens can drive advancements in oncology by means of innovative biobanking.

en-us

33:11

The Future of Drug Development: How Organoids Are...

CrownCast ·

2025/08/05

As the landscape of drug discovery evolves, breakthrough technologies like organoids are gaining traction for their potential to revolutionize how new treatments are developed. In this episode of CrownCast, Jonny McMichael, Vice President at Crown Bioscience, and Leo Price, a member of Crown Bioscience’s Scientific Advisory Board, shed light on organoids' growing role in drug development. With insights into their application, this commentary delves into a technology that offers a significant leap

en-us

24:30

Navigating the Future of Preclinical Testing Post-FDA...

CrownCast ·

2025/06/27

In the relentlessly evolving landscape of drug discovery, modern technologies and groundbreaking methods are going beyond animal testing to ensure a more human-centric, efficient, and improved approach in terms of reliability. It's a journey that promises a more efficient future for pharmaceutical companies and, ultimately, patients worldwide.Dive into the details with industry leader Professor Thomas Hartel, shedding light on how policy changes and innovative technologies are setting the stage for

en-us

24:21

Evolving Biomarkers: Charting the Future of Precision...

CrownCast ·

2025/05/16

In a rapidly shifting landscape of personalized medicine, biomarkers have become central to shaping the way drug development and clinical trials unfold. From predicting therapeutic response to identifying optimal patient populations, the complexity and scope of biomarker use has increased alongside technological advances. A key success story like the BCR-ABL biomarker in chronic myeloid leukemia demonstrates the power of targeted medicine, which has raised five-year survival rates from around 30–50%

en-us

42:08

Pioneering Strategies to Unlocking the Potential of KRAS

CrownCast ·

2025/05/06

Once labeled “undruggable,” KRAS has emerged as one of oncology’s most promising—yet complex—targets. With nearly 90% of pancreatic cancers and 30-40% of lung and colorectal cancers harboring KRAS mutations, the need for effective therapies is urgent. Recent FDA approvals of KRAS G12C inhibitors have signaled a new era, but the rise of resistance and diverse mutation profiles demand deeper innovation. As preclinical tools and combination strategies evolve, scientists must ask: how do we stay ahead

en-us

38:52

Inside Oncology Drug Development: Overcoming...

CrownCast ·

2025/04/19

In the last two decades, oncology has undergone a transformation with over 300 new cancer therapies approved by the FDA—many offering novel mechanisms of action. Despite these innovations, resistance to treatment remains a critical challenge, with cancer cells evolving or adapting to evade even the most advanced therapeutics. This issue is particularly pressing given that resistance often leads to disease relapse, severely impacting patient outcomes and quality of life.As we develop increasingly

en-us

40:00

Exploring Artificial Intelligence in Drug Discovery

CrownCast ·

2025/03/26

Artificial intelligence is rapidly reshaping the drug discovery process, moving from augmenting research to actively driving innovation. As biotech companies face soaring R&D costs and long development cycles, AI promises a breakthrough: slashing drug development time by nearly half while improving accuracy in identifying promising compounds. With global pharmaceutical R&D spending projected to exceed $230 billion by 2026, efficiency isn't just desirable—it's critical.Can AI transition drug

en-us

12:31

Navigating Challenges: Immune Cells vs. Cancer Cells

CrownCast ·

2025/03/25

In the ever-evolving world of cancer treatment, immuno-oncology (IO) continues to stand at the forefront of innovation. With recent FDA approvals for TIL therapies and bispecific antibodies, and new developments in CAR-T technologies, the field is rapidly expanding into combination-based strategies that integrate with standard care. Researchers are also exploring how to overcome challenges posed by the tumor microenvironment and immune cell exhaustion to increase therapeutic success rates.How can

en-us

20:49

Beyond the Lab: The Evolving Role of CROs

CrownCast ·

2025/03/04

Are you ready to understand the seismic shifts in the CRO (Contract Research Organization) industry? Join Johnny McMichael, VP of Client Experience and Enablement at Crown Bioscience, and Alex Slater, Chief Business Officer, as they delve into how strategic partnerships and innovation are redefining drug discovery and development. This video is a must-watch for executives navigating the complexities of outsourcing within the healthcare sector.

en-us

20:14

The Competitive Edge: How CROs Stay Ahead in Drug...

CrownCast ·

2025/02/14

en-us

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