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PODCAST

Depresh Mode with John Moe

John Moe, Maximum Fun

Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people

health & fitness mental health

All Episodes

01:02:46

Andy Frasco Is Figuring Out Who He IS When He’s NOT a...

Depresh Mode with John Moe ·

2026/10/05

Andy Frasco has been hard at work since the age of 13. As an adolescent that meant booking shows, helping out at record labels, running a flag football business. When he was 19, he took his carefully saved Bar Mitzvah money, bought a van, skipped college, and went on tour with his band. Now 38, he’s basically been on that tour ever since, using big energy and charisma to provide the funk and fun with Andy Frasco & The U.N. for big audiences all over. But the Andy we meet in this interview is at

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00:48:27

Gabrielle Moss On Midlife Plot Twists and Just Not...

Depresh Mode with John Moe ·

2026/09/28

Midlife doesn’t need to be a point of crisis, says author Gabrielle Moss. You don’t need to make dangerous choices, blow things up, take a spiritual trek through Nepal, or buy a red convertible. Her new book, Mid-Life Plot Twist, co-written with Lindsay Goldwert, explores how to set boundaries, re-evaluate relationships with work and money and love, and get on a better track. Gaby arrived at this wisdom through personal experience and she tells us of a childhood spent in that one scary house on the

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00:48:23

Mental Illness Before and After Pregnancy with Dr....

Depresh Mode with John Moe ·

2026/09/21

There has been a great deal of press coverage of the Lindsay Clancy case lately. What the world needs more of is first-hand experiences of severe mental health problems both before and after a baby is born. Dr. Kara Zivin is a researcher and professor of psychiatry at the University of Michigan. While pregnant with her son 15 years ago, she experienced a profound depression that turned suicidal. The severity of her illness and the electroconvulsive therapy (ECT) she ultimately received to address it

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00:47:08

Singer Nicole Atkins Doesn’t Recommend Insomnia,...

Depresh Mode with John Moe ·

2026/09/14

The acclaimed singer and songwriter Nicole Atkins is pretty adept at reading clues that something is wrong. After she’d fall asleep on a Saturday and wake up on Monday, she knew it was time to get more aggressive about addressing her insomnia. Years before, a fall down an actual sinkhole made her realize that drinking had become a pretty big problems. On Nicole’s new album Drama, her first in five years and produced by Wilco’s Pat Sansone, she offers many songs that began as mumbled voice memos

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01:03:54

AI Chatbots Destroyed His Reality. Dr. Jeremy Heffner...

Depresh Mode with John Moe ·

2026/09/07

Dr. Jeremy Heffner was a highly educated, high achieving surgeon. Not the kind of person one would expect to slide down an AI chatbot-generated rabbit hole, lose touch with reality, and give credence to the bot’s suggestion that he was one of the three smartest humans ever. But that’s what happened. The bots also told him there was a 70% chance AI would end the world and only Jeremy could save it. His experience, chronicled in his new book, Proof of the Impossible. Jeremy joins us to talk about the

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00:44:45

Best of Depresh Mode: Cameron Esposito on Comedy,...

Depresh Mode with John Moe ·

2026/08/31

Cameron Esposito has many titles: hugely successful standup comedian, actor in television and film, writer, podcast host. After a recent rehab stay led to a mental health diagnosis, she has realized that she’s also a person with bipolar disorder, type II. Cameron has a new special, Four Pills, that’s part stand-up comedy and part reflection on the circumstances that led to this discovery as well as thoughts on what life as a treated person for bipolar will mean going forward. Cameron Esposito joins

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01:04:00

Cat Grief is Real. So is Human Grief. We’re...

Depresh Mode with John Moe ·

2026/08/24

Bay Area journalist s.e. smith thinks the high school goths were right: we should be talking about death all the time. It’s underdiscussed for something that will literally affect us all. And in that silence, they say, things get worse: the topic becomes less approachable, inevitable periods of grief can become more chaotic and disruptive, and the actual pain of losing your person or cat or dog can become harder to process. s.e. went out and talked to dozens of death-related people - death doulas,

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01:07:13

Oh, It’s Autism, Mary H.K. Choi Learned at 43. Okay,...

Depresh Mode with John Moe ·

2026/08/17

Mary H.K. Choi compares living with her brain to just not understanding the operating system on a computer. She didn’t know if this was a result of trauma and neglect in her childhood, the experience of being parentified as a child, grief after the death of her father, or what. So she spent decades of effort and piles of dollars to figure it out. She did cognitive behavioral therapy, internal family systems therapy, “heroic doses of psilocybin under the watchful gaze of a shaman”, and anything else

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01:02:29

Margaret Glaspy Ends Her Instagram Addiction and...

Depresh Mode with John Moe ·

2026/08/10

Margaret Glaspy compares the experience she was having on Instagram to being lightly punched in the gut, over and over, for a very long time. Like it’s not like being hit hard, just a little tap of something negative with each update you read, each comparison made, each distancing away from actual humanity and toward the simulated reality the platform presents. So she quit social media. Which was hard because it was an actual addiction. And then she wrote and recorded her new album, I Am Both, which

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00:49:39

Depression, Loneliness, and Memory Problems Are Worse...

Depresh Mode with John Moe ·

2026/08/03

For most of the world, the advent of middle age does not make depression, loneliness, and memory issues more of a problem than earlier in life. In some countries, things actually get better. The only nation on earth where it all gets worse is right here in the USA. Arizona State University psychologist Frank Infurna has been researching this topic extensively and explains the uniquely American societal forces that are contributing to us being generally more miserable. It’s a lot of things beyond an

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00:59:10

Codependency and Covid on a Tiny Boat in the Middle...

Depresh Mode with John Moe ·

2026/07/27

Angela Harger-Thompson had moved to Hollywood to make it big in showbiz but soon fell victim to a devastating assault. There to comfort her was her intermittent boyfriend. She really liked him and thought his offer of a four-week, 4000 mile sailing voyage on the Pacific Ocean, accompanies by a small crew of strangers and a dog seemed like a good idea. The claustrophobic pressure of that situation, combined with the dangers of ocean travel, was compounded by the rapid emergence of the covid pandemic

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00:55:05

Maybe It IS Time to Panic Over AI Chatbots and Mental...

Depresh Mode with John Moe ·

2026/07/20

This week, we take a look at a couple of acronyms that are soaring in popularity and ask what their widespread adoption means for mental health. Maggie Harrison Dupré of Futurism has been following the AI space closely and has an update on lawsuits related to chatbots’ culpability in numerous cases of attempted and completed suicides. She also explains some recent research about why prolonged engagement with the sycophantic computer programs can lead to spiraling out of reality. Then we’re joined by

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00:51:21

Jo Dee Messina on Hard Times, Jesus, and Her First...

Depresh Mode with John Moe ·

2026/07/13

Jo Dee Messina has a long career in the music industry: number one hits, platinum and gold records, many awards. She’s a country music icon. Jo Dee just released Bridges, her first new album in 12 years and those were 12 years filled with some tough times. Her marriage ended, leaving her as a single mom of two boys, both her parents died, and Jo Dee battled cancer, completed treatment, and is cancer free. She’s reluctant to talk about those events but is very happy to talk about her relationship

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00:50:35

Best of Depresh Mode: Hanif Abdurraqib on Cultivating...

Depresh Mode with John Moe ·

2026/07/06

Hanif Abdurraqib is a MacArthur Fellow, accomplished poet, and critically lauded author of numerous books, including There’s Always This Year: On Basketball and Ascension, which is now out in paperback. He’s also a person who deals with major depressive disorder and numerous anxiety disorders. In a revealing, positive, and practical interview, Hanif talks about the numerous ways he cares for his mental health issues by both taking care of himself and building a strong community of other people

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00:52:06

We Should Praise Addiction, Not Condemn It, Says...

Depresh Mode with John Moe ·

2026/06/29

The title of Elizabeth Roberts’ new book, In Praise of Addiction, is likely to catch your attention, maybe even set off some cognitive dissonance in your mind. But the University of Michigan’s Elizabeth Roberts doesn’t want you to be unhealthy or take up new habits that can hurt you and others, she just wants you to consider that maybe we haven’t been looking at addiction with the clearest of eyes. Why are some substances and habits tolerated and others scorned, their users told by society to

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00:46:10

Cartoonist Gemma Correll Saw a Therapist with a...

Depresh Mode with John Moe ·

2026/06/22

British-born, LA-based author and illustrator Gemma Correll had a couple of reasons to choose the motif of an amusement park for her new anxiety book, Anxietyland. One, she loves amusement parks and wanted to be able to write off a Disneyland trip as a research expedition. And also, there are so many great metaphors to be found there like emotional rollercoasters and a worry-go-round. With hilarious candor, Gemma shares her own story about fearing coyotes would eat her pets (there are no coyotes in

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00:50:15

RFK Jr. Wants To Take Your SSRIs Away. So What Are...

Depresh Mode with John Moe ·

2026/06/15

Secretary of Health & Human Services Robert F. Kennedy, Jr. is, to put it mildly, a skeptic of selective serotonin reuptake inhibitor (SSRI) medication, a form of meds that millions of Americans use regularly with tremendous benefit. He was once on SSRIs, went off them, then became addicted to heroin, and he believes these events are linked. He also believes they cause school shootings and cause harm to developing fetuses. There is no evidence to support this. Andrea Salinas, a Democrat who

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01:04:46

Robyn Hitchcock is Fundamentally Delusional, Welcomes...

Depresh Mode with John Moe ·

2026/06/08

If you’ve ever listened to Robyn Hitchcock’s music, you know that it can get pretty surrealistic. Some might say divinely bizarre and eclectic. Others might just say weird. All of that’s fine with the London-born, Nashville-based artist, who has been putting out music on his own and with The Soft Boys and The Egyptians for half a century. Robyn says he’s very happy to be in touch with a world beyond the view of the average human and enjoys communicating that world to the rest of us. Part of it has

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00:58:16

Blake Mycoskie Helped the World, Got Rich, Retired to...

Depresh Mode with John Moe ·

2026/06/01

There is no Tom behind TOMS Shoes. It’s short for “Tomorrow’s.” There is a Blake, however. Blake Mycoskie founded the company in 2006 under the model that for every pair sold, a second pair would be donated to children in the developing world. TOMS took off, which meant years of constant work for Blake, traveling the world telling the TOMS story, and ultimately getting burned out and selling the company. Despite all the snowboarding he could now do, Blake found himself without purpose and lonely

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00:53:51

An Episode About the Grind, Singer Zayna Youssef of...

Depresh Mode with John Moe ·

2026/05/25

Yes, the episode is about a rock singer but it’s also about any of us who grind away for the benefit of our work and the detriment of ourselves. The sudden cancellation of the band Sweet Pill’s extensive tour promoting their sophomore album Still There’s a Glow came as a shock to fans and the press. But it makes total sense given that singer Zayna Youssef had been working herself into the ground with writing, recording, designing merch and album covers and backstage passes, and everything else she

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311 results

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