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PODCAST

Questioning Medicine

Questioning Medicine

Join Andrew on a medical rollercoaster as we ask a medical question and answer it based on recent published papers.

health & fitness medicine

All Episodes

16:34

Episode 426: 433. Salt, Statins, and Stents

Questioning Medicine ·

2026/04/21

Donato J, et al. Things We Do For No Reason™: Low salt diets for patients with acute heart failure. J Hosp Med 2026 Feb 4; [e-pub]. DOI: 10.1002/jhm.70278.Some guidelines now recommend "normal sodium intake" for patients with acute and chronic HF, which means avoiding excessive sodium intake and staying under 4 to 5 g daily.https://academic.oup.com/eurjhf/article-abstract/26/4/730/8328801?redirectedFrom=fulltext&login=trueLuo Y, et al. Measuring public preferences for statin therapy:

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34:03

Episode 425: 432. CME LECTURE- Under Pressure,...

Questioning Medicine ·

2026/04/18

432. CME LECTURE- Under Pressure, Blood Pressure

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18:26

Episode 424: 431. Gout should we treat to a number?...

Questioning Medicine ·

2026/04/14

https://www.sciencedirect.com/science/article/abs/pii/S2665991326000342?via%3Dihublancet rheumatology A treat-to-target strategy versus symptom-driven management of gout in the Netherlands (GO TEST Overture): a multicentre, open-label, pragmatic, superiority, randomised controlled trial The question on the table: Is chasing a serum urate level below six milligrams per deciliter worth the effort? Or are we just torturing our patients with more lab draws and dose titrations than they

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12:36

Episode 423: 430. Hormone Replacement Therapy and the...

Questioning Medicine ·

2026/03/24

Let’s rewind to the early 2000s. Flip phones were cool, low-rise jeans were a crime, and the Women’s Health Initiative—WHI—dropped what became the medical equivalent of a headline: “Hormone Therapy Increases Risk!” The study looked at one very specific regimen: an oral pill with conjugated equine estrogens—yes, horse estrogens—and medroxyprogesterone acetate, or MPA, taken every day by women with an average age of 63.Now, 63 is not “just hit menopause.” That’s about 12 years past menopause

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10:03

Episode 422: 429. Rivaroxaban vs Apixaban = The...

Questioning Medicine ·

2026/03/20

— rivaroxaban versus apixaban.Yes, folks, this is The Battle of the Blood Thinners!And spoiler alert — one of them came out looking like the overachiever in a safety class... while the other probably needs a little extra padding on its report card.The SetupSo here’s the story. For years, observational studies hinted that apixaban — we’ll call it “Api” because we’re friendly like that — might be gentler when it comes to bleeding compared to rivaroxaban — or “Riva,” who sounds like she’d stir

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16:48

Episode 421: 428. Asthma and Stroke --- A breathless...

Questioning Medicine ·

2026/03/13

Minocycline in Acute Ischemic Stroke (EMPHASIS trial)A multicenter, double-blind RCT in China studied 1,724 patients with acute ischemic stroke treated within 72 hours of onset. Patients received either a 4.5-day course of oral minocycline or placebo. Minocycline works by inhibiting microglial activation, which contributes to post-stroke inflammation.Primary outcome: 52.6% of minocycline patients vs. 47.4% of placebo patients achieved good functional recovery (mRS 0–1) at 90 days

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7:45

Episode 420: 427. Kawasaki disease-no, not the...

Questioning Medicine ·

2026/03/11

Today, we're talking about Kawasaki disease-no, not the motorcycle company, though sometimes treating it does feel like trying to ride one at full speed through uncertainty.For decades, high-dose aspirin was basically the holy water of Kawasaki treatment. Eighty to a hundred milligrams per kilogram per day-because apparently, kids with vasculitis also needed a little side of tinnitus. But here's the twist: new research says... maybe we didn't need all that aspirin after all.Researchers at

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11:14

Episode 419: 426. Go Big or Go Partial? The Knee...

Questioning Medicine ·

2026/03/10

Setting the stagePicture this: your knee is like a three-room apartment. You've got a medial room, a lateral room, and a patellofemoral room. In isolated anteromedial osteoarthritis, just one room is trashed. The rest of the apartment still looks like something you'd put on a rental listing. So surgeons have two choices: Option A: Total knee arthroplasty, or TKA - bulldoze the entire apartment and rebuild it. Option B: Medial unicompartmental knee arthroplasty, or UKA - fix the one bad room

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6:40

Episode 418: 425. Triptan initiation and...

Questioning Medicine ·

2026/03/06

Kalapura C, et al. Triptan initiation and cerebrovascular events in patients with migraine: A nationwide cohort study. J Am Heart Assoc 2026 Feb 17; 15:e043409. DOI: 10.1161/JAHA.125.043409. Today, we're talking triptans - those long-trusted migraine relievers - and a new study that asks a not-so-relaxing question: could they slightly raise the risk of ischemic stroke? Let's break it down. Researchers analyzed data from 870,000 adults with migraine and no previous vascular events. The

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8:20

Episode 417: 424. GLP1 and NAION

Questioning Medicine ·

2026/03/05

Li H-Y, et al. GLP-1 receptor agonists and risk of optic nerve or vision-threatening events in patients with type 2 diabetes or cardiometabolic diseases: A meta-analysis of randomized controlled trials. Diabetes Care 2026 Mar 1; 49:526. DOI: 10.2337/dc25-1929.Heberer K, et al. New-onset nonarteritic anterior ischemic optic neuropathy and initiators of semaglutide in US veterans with type 2 diabetes. JAMA Ophthalmol 2026 Feb 12; [e-pub]. DOI: 10.1001/jamaophthalmol.2025.6262.Noh Y, et al

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45:23

Episode 416: 423. CME-- Discharge Questions Answered...

Questioning Medicine ·

2026/03/03

CME-- Discharge Questions Answered in 2025

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6:23

Episode 415: 422. Finerenone restores fertility?

Questioning Medicine ·

2026/03/02

Lin Z, et al. Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency. Science 2026 Feb 5; 391:eadz4075. DOI: 10.1126/science.adz4075. Premature ovarian insufficiency is usually one of those diagnoses that shuts the door on fertility: ovarian function is lost before age 40, mature follicles are scarce to nonexistent, and we have no reliable way to turn things back on. In most textbooks, that's the end of the story. A group in Hong Kong is now asking a different

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11:42

Episode 414: 421. Scabies and DUKE criteria

Questioning Medicine ·

2026/02/25

Stavropoulou E, et al. Reassessing the 2023 International Society for Cardiovascular Infectious Diseases Duke clinical criteria for infective endocarditis: Impact of excluding fever and updating diagnostic definitions. Clin Infect Dis 2025 Dec 31; [e-pub]. DOI: 10.1093/cid/ciaf737. Big takeawaysAbout 35% of patients truly had IE. Fever showed up in 80% of patients both with and without IE, so it did not help distinguish them. Dropping fever from the criteria actually made them

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19:37

Episode 413: 420. Frail and CODE LVO PLUS antibiotics...

Questioning Medicine ·

2026/02/05

we look at CODE LVO and what does being frail even mean?????vaccines may not help baby and antibiotics still don't help viral illness

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3:09

Episode 412: CME song --Check the Lytes

Questioning Medicine ·

2026/01/20

CME song --Check the Lytes

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43:02

Episode 411: CME - sodium, potassium, calcium

Questioning Medicine ·

2026/01/20

CME - sodium, potassium, calcium

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40:49

Episode 410: 418. Beta Blockers Post MI, PSA, Youtube,

Questioning Medicine ·

2025/12/15

10.1016/j.jaip.2025.07.005.40675327All of the videos were found to be useful or very useful, 99% were of moderate or high reliability, and 99% had moderate to excellent educational quality Prostate-specific antigen levels among participants receiving annual testing. JAMA Oncol 2025 Nov; 11:1341 10.1001/jamaoncol.2025.3386.40965920PSA levels at or above 4.0 ng/mL fell below that threshold on the next annual test 30% of the time. 10.1016/S2665-9913(25)00250-4.During 10 years of follow-up,

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34:04

Episode 409: 417. Aspirin, Pre-diabetes, Menopause,...

Questioning Medicine ·

2025/12/03

Wolfe R, Broder JC, Zhou Z, et al. Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE trial. Eur Heart J. 12 Aug 2025. [Epub ahead of print]. https://pubmed.ncbi.nlm.nih.gov/40796244/ Donocan LE et al. Closed-loop insulin delivery in type 1 diabetes in pregnancy: The CIRCUIT randomized clinical trial. JAMA 2025 Oct 24; [e-pub].

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22:55

Episode 408: 416. Car Seats, Beta-Blockers after a...

Questioning Medicine ·

2025/11/17

Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction - https://www.nejm.org/doi/full/10.1056/NEJMoa2504735?query=WB McGuire DK et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med 2025 Mar 29; [e-pub]. (https://doi.org/10.1056/NEJMoa2501006) Interactive Virtual Presence to Remotely Assist Parents With Car Seat Installation https://pubmed.ncbi.nlm.nih.gov/41077424/ Effectiveness of high-dose influenza vaccine against

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9:34

Episode 407: 415. Do Air Filters Lower Blood Pressure?

Questioning Medicine ·

2025/11/12

https://pubmed.ncbi.nlm.nih.gov/40767818/This is a great example for students and residents to look and see that the abstract does not always match what the paper actually says

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389 results

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