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PODCAST

Questioning Medicine

Questioning Medicine

Join Andrew on a medical rollercoaster as we ask a medical question and answer it based on recent published papers.

health & fitness medicine

All Episodes

62:42

Episode 400: 408. CME Obesity and MASH

Questioning Medicine ·

2025/09/27

GLP1 drugs work but they likely need lifestyle modificationsNo convincing evidence GLP1 cause thyroid cancer in humans BUT contraindication if family history existStopping therapy usually results in weight gainInsurance coverage for weight loss is limited and variable Semaglutide for type 2 diabetes max dose is 2.0 mg weekly Semaglutide for weight loss has a goal dose of 2.4 mg weekly Diagnose steatotic liver disease with imaging and 1 metabolic risk factor (or biopsy) After diagnosis

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39:38

Episode 399: 407. OMED COPD CME

Questioning Medicine ·

2025/09/22

OMED COPD CME

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29:58

Episode 398: 406. Update of Medical Articles

Questioning Medicine ·

2025/08/27

All of these articles have been talked about on questioning medicine social media on tik tok and instagram but here is an update of my recent reading

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19:00

Episode 397: 405. 4 New Medical Articles That Are...

Questioning Medicine ·

2025/08/01

Buelt, Andrew | 2:13 PM (1 hour ago) | | to mehttps://jamanetwork.com/journals/jama/fullarticle/2833338 Conclusions and Relevance These results support use of metformin for treatment of symptomatic knee osteoarthritis in people with overweight or obesity. Because of the modest sample size, confirmation in a larger clinical trial is warranted. Lee S et al. Live zoster vaccination and cardiovascular outcomes: A nationwide, South Korean study. Eur Heart J 2025 May 5; [e-pub].

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12:03

Episode 396: 404. albuterol/budesonide, DOAC in 4...

Questioning Medicine ·

2025/07/24

https://www.nejm.org/doi/10.1056/NEJMoa2504544 During follow-up ranging from 12 to 52 weeks, fewer patients had severe exacerbations in the albuterol/budesonide group than in the albuterol group (5% vs. 9%). Patients in the albuterol/budesonide group had less than half the total exposure to systemic glucocorticoids as those in the albuterol group (mean, 23 vs. 62 mg per year). Clinical Practice: This study supports the use of an as-needed combination of albuterol and budesonide in

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10:28

Episode 395: 403. COVID Maternal Booster And Cervical...

Questioning Medicine ·

2025/07/22

https://publications.aap.org/pediatrics/article/156/1/e2024070175/202234/Infant-Antibodies-After-Maternal-COVID-19?autologincheck=redirected Objective:The study aimed to evaluate the kinetics and duration of maternally derived antibodies in infants up to 6 months old, following maternal COVID-19 vaccination during pregnancy or postpartum. Study Design:A prospective multicenter cohort study was conducted across nine U.S. academic sites, enrolling infants born to mothers vaccinated with

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15:05

Episode 394: 402. Cardiovascular Risk Factors,...

Questioning Medicine ·

2025/07/18

https://www.nejm.org/doi/10.1056/NEJMoa2415879?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Key Findings:Classic Risk Factors: The five risk factors examined were hypertension, hyperlipidemia, underweight and overweight or obesity, diabetes, and smoking. These factors are estimated to account for about 50% of the global burden of cardiovascular disease. Lifetime Risk Estimates: Among individuals free of these risk factors at age 50, the lifetime

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4:41

Episode 394: 405. Several Articles, lots of information

Questioning Medicine ·

2025/07/07

https://pubmed.ncbi.nlm.nih.gov/40443569/ Candida hypertension guidelines start with Polly pill https://pubmed.ncbi.nlm.nih.gov/40562047/ Once weekly insulin equal to once daily insulin https://www.jwatch.org/na58924/2025/06/26/new-single-pill-three-drug-combination-hypertension?query=etoc_jwhospmed&jwd=000020154104&jspc=HOS&cid=DM2406155_Subscriber&bid=-1280218728 FDA-approved new triple Polly pill https://pubmed.ncbi.nlm.nih.gov/40517008/ For carpal tunnel syndrome I do

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12:30

Episode 393: 404. 3 quick articles you might want to...

Questioning Medicine ·

2025/06/25

GLP1 might cause thyroid cancer in mice but the evidence is drastically lacking in humansOral semaglutide is expensive for an NNT of 50 at 4 yrsTiktok videos of skin care are a scam

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14:11

Episode 392: 403. 3 Papers, 1 Podcast - One Guideline...

Questioning Medicine ·

2025/06/16

https://jamanetwork.com/journals/jama/article-abstract/2834040amiloride is realistically equal to spironolactone for resistant HTNhttps://journals.lww.com/ajg/abstract/2025/05000/higher_rate_of_spontaneous_bacterial_peritonitis.24.aspxprophalaxis antibiotics might not be neededhttps://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2834317If you got a friend in weight loss-- or at least in maintaining weight loss

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7:45

Episode 391: 402. Functional disability after...

Questioning Medicine ·

2025/06/05

https://www.jthjournal.org/article/S1538-7836(25)00109-6/fulltextAntithrombotic agents, like aspirin and anticoagulants, are essential for treating many cardiovascular conditions. However, a common side effect is bleeding, with extracranial bleeding—bleeding outside the brain and spinal cord—being quite prevalent. This study, a secondary analysis of the Aspirin in Reducing Events in the Elderly, or ASPREE trial, aimed to explore how clinically significant extracranial bleeding affects the

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8:46

Episode 390: 401. Add-On Treatment With Zilebesiran...

Questioning Medicine ·

2025/06/04

https://jamanetwork.com/journals/jama/article-abstract/2834632SummaryThe article examines the effectiveness and safety of zilebesiran, an RNA interference therapeutic agent, when used in combination with standard first-line antihypertensive drugs for patients with inadequately controlled hypertension. The phase 2, prospective, randomized, double-blinded trial was conducted over multiple international sites with patients treated with either indapamide, amlodipine, or olmesartan. The primary

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9:37

Episode 389: 400. CRP, Lipoprotein A, LDL for cardiac...

Questioning Medicine ·

2025/05/29

https://www.nejm.org/doi/full/10.1056/NEJMoa2405182?query=recirc_Semantic Key TakeawaysExtended Predictive Value of Biomarkers: High-sensitivity C-reactive protein (CRP), LDL cholesterol, and lipoprotein(a) levels were found to be predictive of cardiovascular events over a 30-year period. These markers contribute independently to long-term cardiovascular risk beyond traditional 10-year risk estimates. Study Design and Population: The study enrolled 27,939 initially healthy U.S. women

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7:48

Episode 388: 399. Use of albumin-adjusted calcium...

Questioning Medicine ·

2025/05/27

Desgagnés N et al. Use of albumin-adjusted calcium measurements in clinical practice. JAMA Netw Open 2025 Jan 21; 8:e2455251. (https://doi.org/10.1001/jamanetworkopen.2024.55251)Overall, total calcium levels (just the ones we would get back on a basic cmp) correlated better with ionized calcium than did formula-corrected calcium levels. Formulas with stronger correlation than total calcium levels were either complex (e.g., requiring blood pH measurement) or derived locally (i.e., not

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8:38

Episode 387: 398. Which is Better, Tirzepatide or...

Questioning Medicine ·

2025/05/21

https://www.nejm.org/doi/10.1056/NEJMoa2416394At 72 weeks, the mean percentage decrease in weight was significantly greater with tirzepatide than with semaglutide (20% vs. 14%). Gastrointestinal side effects occurred frequently in both groups but led to discontinuation of treatment in only 3% and 6% of participants in the tirzepatide and semaglutide groups, respectively. Injection-site reactions were more common with tirzepatide than with semaglutide (9% vs. <1%) but didn't cause

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5:25

Episode 386: 397. What is the new drug for smoking...

Questioning Medicine ·

2025/05/09

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701In this multisite trial, 800 adults who smoked 10 or more cigarettes daily (mean duration of smoking, ≈35 years) were randomized to 6 or 12 weeks of cytisinicline or to placebo. In the 6-week group,15% of cytisinicline recipients and 6% of placebo recipients were abstinent (defined by self-report and breath carbon monoxide <10 ppm) during weeks 3 to 6. In the 12-week group, 30% of cytisinicline recipients and 9% of

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8:56

Episode 385: 396. Vitamin D and Kids (CME)

Questioning Medicine ·

2025/05/07

What does the evidence and the guidelines say about the use and testing of Vitamin D in kids

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5:18

Episode 384: 395. How accurate is the BMI?

Questioning Medicine ·

2025/05/06

Aryee EK et al. Prevalence of obesity with and without confirmation of excess adiposity among US adults. JAMA 2025 Apr 17; [e-pub]. (https://doi.org/10.1001/jama.2025.2704)The rate of obesity was 39.7% based on BMI and 39.1% based on excess adiposity. Among participants with obesity based on BMI, 98% also had excess adiposity; in other words, essentially the same individuals were considered as obese by both criteria.

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7:28

Episode 383: 394. Does the time of day effect...

Questioning Medicine ·

2025/05/02

In an hour-by-hour analysis, patients we suspect to have asthma are significantly more likely to have positive bronchodilator responses early in the morning; with each passing hour before testing, there was small decrease (8%) in positive response. Patients also were more likely to have positive responses in the winter. Knox-Brown B et al. Effect of time of day and seasonal variation on bronchodilator responsiveness: The SPIRO-TIMETRY study. Thorax 2025 Mar 11; [e-pub].

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38:43

Episode 382: 393. CME-- Vitamin D and Adults

Questioning Medicine ·

2025/05/01

Vitamin D and Adults and what you should do with Vitamin D

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363 results

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