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PODCAST

PACUPod: Critical Care

PACUPod is your trusted source for evidence-based insights tailored to advanced clinical pharmacists and physicians. Each episode dives into the latest primary literature, covering medication-focused studies across critical care and many more. We break down study designs, highlight key findings, and objectively discuss clinical implications—without the hype—so you stay informed and ready to apply new evidence in practice. Whether you’re preparing for board certification or striving for excellence in

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All Episodes

14:36

propofol vs midazolam for ICU sedation — PACUPod

PACUPod: Critical Care ·

2026/03/23

Clinical research summary for "propofol vs midazolam for ICU sedation":[PubMed] 10 articles found for "propofol vs midazolam for ICU sedation" (PMIDs: 22436955, 39100810, 36795623, 11296183, 9470082)

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8:29

Diastolic Perfusion Pressure Predicts Response to...

PACUPod: Critical Care ·

2025/11/20

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7:39

Early Vasopressor Utilization in Critically Ill...

PACUPod: Critical Care ·

2025/11/20

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10:05

Use of a drug-related problem oriented medical record...

PACUPod: Critical Care ·

2025/09/03

Join PACULit as we unpack a randomized clinical trial evaluating a drug-related problem oriented medical record (DAM) used during medication reviews for critically ill patients. The study, conducted in two Brazilian ICUs, randomized 150 adults likely to require mechanical ventilation or with organ dysfunction to DAM-enabled medication review versus standard practice. Primary outcome was hospital length of stay; key secondary outcomes included in-hospital mortality and changes in SOFA

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9:12

Association Between Rewarming Rate and Survival and...

PACUPod: Critical Care ·

2025/09/03

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0:17

Early fluid balance and mortality following...

PACUPod: Critical Care ·

2025/09/03

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5:47

Unsupervised machine learning analysis to identify...

PACUPod: Critical Care ·

2025/09/03

In this PACULit episode, Britany and Seth discuss Keats et al.'s study that uses unsupervised machine learning on ICU intravenous medication data to identify pharmacophenotypes associated with fluid overload. By applying principal component analysis for dimensionality reduction and a restricted Boltzmann machine clustering algorithm to 72-hour medication records from 927 adults in a single ICU, the study reveals clusters of similar med usage patterns. One cluster (Cluster Seven), rich in

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8:43

Performance of broad-spectrum targeted...

PACUPod: Critical Care ·

2025/09/03

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10:42

Vasopressor or advanced airway first in cardiac...

PACUPod: Critical Care ·

2025/09/03

In this PACULit episode, Britany and Seth analyze a secondary analysis of the Pragmatic Airway Resuscitation Trial (PART) to address whether vasopressors or advanced airway placement should come first during out-of-hospital cardiac arrest. The study found no significant differences in 72-hour survival, return of spontaneous circulation, hospital survival, or neurological outcomes between the two sequences, suggesting EMS teams can tailor their approach to the clinical context while

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9:03

Intraosseous vs intravenous access during out of...

PACUPod: Critical Care ·

2025/09/03

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0:02

Effects of very early hyperoxemia on neurologic...

PACUPod: Critical Care ·

2025/09/03

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6:05

Antibiotic De-Escalation Practices in the Intensive...

PACUPod: Critical Care ·

2025/09/03

{"episode_description": "PACUPod – PACULit Daily Literature Update\nEpisode: Antibiotic De-Escalation in the ICU – A Multicenter Observational Study\nIn this episode, we review the multicenter observational study “Antibiotic De-Escalation Practices in the Intensive Care Unit: A Multicenter Observational Study” by Patanwala, Abu Sardaneh, Alffenaar, and colleagues, published in the Annals of Pharmacotherapy (April 2025; PMID 39192570). We summarize what antibiotic de-escalation (ADE) is,

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5:59

Stress hyperglycemia ratio as a biomarker for early...

PACUPod: Critical Care ·

2025/09/03

{"episode_description":"PACULit Daily Literature Update: Stress hyperglycemia ratio as a biomarker for early mortality risk stratification in cardiovascular disease — a propensity matched analysis. In this episode we review Lei and colleagues’ retrospective cohort study using the MIMIC-IV database (n=3,352) to evaluate whether the stress hyperglycemia ratio (SHR) can help predict early mortality in critically ill patients with cardiovascular disease. SHR was analyzed in quartiles, with

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6:26

Evaluation of Stress Dose Hydrocortisone Tapers in...

PACUPod: Critical Care ·

2025/09/03

{ "episode_title": "PACUPod: Stress Dose Hydrocortisone Tapers in Septic Shock – Retrospective Cohort Review", "episode_description": "AI-powered literature briefing from PACUPod. This episode reviews a retrospective cohort study published in Hosp Pharm by Gilchrist et al., evaluating how stress-dose hydrocortisone tapers were used in 276 ICU patients with septic shock between 2020 and 2023. Key findings: about half of patients underwent a taper, with the most common method being

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5:43

Evaluation of Etomidate Use and Association with...

PACUPod: Critical Care ·

2025/09/03

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5:49

Fludrocortisone to treat patients with aneurysmal...

PACUPod: Critical Care ·

2025/09/03

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4:59

Inhaled isoflurane for sedation of mechanically...

PACUPod: Critical Care ·

2025/09/03

{ "podcast": "PACUPod", "episode_title": "IsoCOMFORT: Inhaled isoflurane for sedation of mechanically ventilated children in intensive care", "episode_description": "A concise AI-assisted overview of the IsoCOMFORT trial (Lancet Respiratory Medicine) comparing inhaled isoflurane sedation versus intravenous midazolam in mechanically ventilated children. The episode covers study design, non-inferiority for sedation efficacy, potential benefits (opioid- and muscle relaxant-sparing

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6:01

Establishing discordance rate of estimated glomerular...

PACUPod: Critical Care ·

2025/09/03

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6:12

Machine Learning Accurately Predicts Need for...

PACUPod: Critical Care ·

2025/09/03

{ "podcast": "PACUPod", "episode_title": "Machine Learning Accurately Predicts Need for Critical Care Support in Community-Acquired Pneumonia", "description": "In this PACUPod update, we summarize a retrospective observational study from Critical Care Explorations that develops machine learning models to predict the need for invasive ventilation, vasopressors, and renal replacement therapy in adults admitted with community-acquired pneumonia (CAP). Among models tested (random forest,

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8:46

Respiratory syncytial virus infection in adult and...

PACUPod: Critical Care ·

2025/09/02

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