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PODCAST

JACC Global

American College of Cardiology

Explore cardiovascular science from a global perspective with JACC Global. This podcast highlights original research, regional innovations, and urgent challenges in heart health across diverse healthcare settings worldwide.

health & fitness medicine

All Episodes

29:36

M-TEER: Challenging the Status Quo With...

JACC Global ·

2026/01/13

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Hiroshi Tsunamoto to discuss his JACC study from the OCEAN-Mitral Registry, examining how transmitral pressure gradients (TMPG) and residual mitral regurgitation (MR) jointly determine outcomes after transcatheter edge-to-edge repair (M-TEER) for functional MR. In over 2,300 patients, higher postprocedural TMPG (≥5 mmHg) was consistently associated with worse 2-year outcomes, regardless of residual MR severity, while patients achieving MR

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37:15

PREVENT in East Asia: Can One Risk Score Fit All? |...

JACC Global ·

2026/01/06

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Prof. Kosuke Inoue (Kyoto University) and Dr. Yuichiro Mori (Kyoto University) to discuss their JACC Brief Report, “Evaluation of the PREVENT Equations in a Nationwide Cohort of 7.7 Million Korean Adults.” Using one of the world’s largest national health databases, the study externally validates the AHA-developed PREVENT risk equations in an East Asian population, showing good discrimination and calibration for ASCVD, outperforming the

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34:38

“Just One Drink?” Think Again — Blood Pressure Says...

JACC Global ·

2025/12/23

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, welcome Dr. Takahiro Suzuki to discuss his JACC paper, “Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis.” Using a two-cohort design—cessation among habitual drinkers and initiation among nondrinkers—the study demonstrates dose-dependent blood pressure effects when alcohol intake is reduced or begun, and importantly fills a major evidence gap for women and for

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29:00

CT-Based Plaque Norms: Rethinking Risk in Healthy...

JACC Global ·

2025/12/16

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD welcome Dr. Keishi Ichikawa, MD (Lundquist Institute at Harbor–UCLA) to discuss his JACC: Cardiovascular Imaging study from the Miami Heart Study, defining the population norms of coronary plaque using AI-based coronary CT angiography. In 2,301 asymptomatic adults, AI detected plaque in nearly 9 out of 10 individuals —providing age- and sex-specific nomograms for calcified and noncalcified plaque. The episode explores how these data

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38:43

Leave Nothing Behind: The Current and Future of...

JACC Global ·

2025/12/09

Hosts Mitsuaki Sawano, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD welcome Prof. Yoshinobu Onuma (University of Galway)—Last Author of the ARC Position Statement—along with guest commentators Prof. Ken Kozuma (Teikyo University) and Dr. Taku Asano (St. Luke’s International Hospital) to discuss the evolving role of drug-coated balloons (DCBs) in coronary intervention. The conversation highlights key insights from the ARC document, including DCB technology classifications, drug and coating

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31:09

A Global Look at Heart Disease: What the GBD Study...

JACC Global ·

2025/12/02

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Prof. Shuhei Nomura, PhD (Tohoku University) for an in-depth discussion of the landmark JACC Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2023 analysis, covering data from 204 countries and territories. Dr. Nomura, a leading member of the Global Burden of Disease (GBD) collaboration, explains how cardiovascular disease—still largely preventable—now accounts for an increasing share of global health loss, with metabolic risks

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29:21

Ten Seconds That Matter: Clinical Frailty Scale in...

JACC Global ·

2025/11/25

Hosts Mitsuaki Sawano, MD, and Nobuhiro Ikemura, MD, welcome Dr. Taisuke Nakade (Juntendo University) and Dr. Yuya Matsue (Juntendo University) to discuss how a simple Clinical Frailty Scale (CFS) captures multidimensional vulnerability and predicts outcomes in heart failure. Drawing on 3,905 patients (mean age 73 years) from the nationwide JROAD-HF NEXT registry, the JACC study (Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure, 2025;

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36:10

When MRI Falls Short: ICE Identifies Arrhythmogenic...

JACC Global ·

2025/11/18

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, Nobuhiro Ikemura and Satoshi Shoji, MD, welcome Naohiko Sahara, MD (Toho University Ohashi Medical Center) to discuss his JACC: Clinical Electrophysiology study on intracardiac echocardiography (ICE) for detecting periaortic ventricular tachycardia substrate. In a multimodality core lab analysis, Dr. Sahara showed that ICE outperformed cardiac MRI in identifying arrhythmogenic scars, with wall thinning <0.6 cm predicting substrate even when no LGE was

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57:35

SimPub at AHA 2025 | JACC Baran

JACC Global ·

2025/11/10

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD, highlight JACC Simultaneous Publications from the AHA 2025 Scientific Sessions, featuring three impactful clinical trials: (1) Effect of Aficamten vs. Metoprolol on Patient-Reported Health Status in Obstructive Hypertrophic Cardiomyopathy, (2) Sacubitril/Valsartan vs. Enalapril in Heart Failure Due to Chagas Disease (ANSWER-HF Trial), and (3) Behavioral Economics and Medication Adherence for Hypertension. These SimPub studies

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27:49

TAVR, von Willebrand Factor, and Bleeding: Refining...

JACC Global ·

2025/11/04

Host Mitsuaki Sawano, MD, welcome Dr. Shinnosuke Kikuchi, MD of Yokohama City University Medical Center to discuss how closure time–ADP (CT-ADP) refines bleeding risk after TAVR beyond VARC-HBR criteria. Based on data from 884 patients in the Strasbourg TAVR registry, the study (JACC: Cardiovasc Interv. 2025; doi:10.1016/j.jcin.2025.08.011) showed that CT-ADP >180 s independently predicted both periprocedural and late major bleeding, even among patients already classified as high risk.

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33:35

Primetime for Cardiovascular AI: The PRIME 2.0...

JACC Global ·

2025/10/28

Hosts Dr. Mitsuaki Sawano, Dr. Kentaro Ejiri, and Dr. Satoshi Shoji welcome Dr. Nobuyuki Kagiyama of Juntendo University and Dr. Shinichi Goto of Tokai University to discuss PRIME 2.0: An Update to the Proposed Requirements for Cardiovascular Imaging–Related Machine Learning Evaluation Checklist, recently published in JACC. Building on the original 2020 PRIME framework, this global collaboration revises the checklist to keep pace with rapid advances in AI—from deep learning and multimodal data

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35:47

Frailty Across the Spectrum of Ejection Fraction |...

JACC Global ·

2025/10/21

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD, welcome Drs. Kensuke Ueno (The University of Tokyo), Kentaro Kamiya (Kitasato University), and Tetsuya Takahashi (Juntendo University) to discuss the role of frailty in shaping cardiovascular versus noncardiovascular mortality across left ventricular ejection fraction (LVEF) subtypes. They provide expert commentary on the recent JACC: Heart Failure publication (Frailty Phenotype and Cardiovascular vs Noncardiovascular Mortality:

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31:06

Patient Journeys of Angina: What ISCHEMIA Tells Us |...

JACC Global ·

2025/10/14

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD, welcome Dr. Nobuhiro Ikemura of Tachikawa Hospital, formerly of Saint Luke’s Mid America Heart Institute to discuss trajectories of angina following initial invasive versus conservative strategies for chronic coronary disease. Dr. Ikemura provides expert commentary on the recent JACC publication (Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease, ISCHEMIA Research

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41:40

From Pixels to Precision: AI in Echocardiography |...

JACC Global ·

2025/10/07

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, Satoshi Shoji, MD, and Nobuhiro Ikemura, MD, welcome Dr. Yuki Sahashi of Cedars-Sinai Medical Center and the Ouyang Lab to discuss artificial intelligence automation of echocardiographic measurements and its cardiovascular implications. Dr. Sahashi provides expert commentary on the recent JACC publication (J Am Coll Cardiol. 2025; doi:10.1016/j.jacc.2025.07.053), which developed and validated 18 open-source deep learning models using 877,983

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27:26

Heart Failure in Japan’s Oldest-Old: A Super-Aging...

JACC Global ·

2025/09/30

Hosts Dr. Mitsuaki Sawano, Dr. Kentaro Ejiri, and Dr. Satoshi Shoji welcome Dr. Takeshi Kitai and Dr. Koshiro Kanaoka of the National Cerebral and Cardiovascular Center to discuss their JACC study, Heart Failure in the Oldest-Old: A Growing Clinical and Economic Burden in Aging Japan. Drawing on over 730,000 HF hospitalizations from the JROAD-DPC registry (2016–2022), they reveal how the proportion of patients ≥85 years rose to nearly half of all admissions, with associated costs surging from $870M

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36:41

CHIPping the Code: Clonal Hematopoiesis and CV...

JACC Global ·

2025/09/23

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD, welcome Dr. Shunsuke Inoue of The University of Tokyo to discuss clonal hematopoiesis of indeterminate potential (CHIP) and its cardiovascular implications. Dr. Inoue provides expert commentary on two recent JACC publications: a Women’s Health Initiative analysis linking CHIP mutations such as TET2, ASXL1, and JAK2 with distinct cardiovascular outcomes in older women, and an exploratory substudy of the LoDoCo2 trial examining

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48:41

Single Cells, Spatial Maps, Big Insights: Rewiring...

JACC Global ·

2025/09/16

Hosts Mitsuaki Sawano, MD, and colleagues welcome Dr. Jun Yasuhara (Center for Cardiovascular Research and Heart Center, Nationwide Children’s Hospital) and Dr. Toshiomi Katsuki (Saitama City Hospital) for a Basic to Translational Science special. Dr. Jun Yasuhara presents his mouse model study on congenital aortic valve disease, showing how disruption of NOTCH1 and GATA5 produces a highly penetrant, clinically relevant bicuspid aortic valve and progressive aortic stenosis phenotype. Dr. Toshiomi

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25:57

ARVC at 40+: Clinical Insights From a 20-Year Study

JACC Global ·

2025/09/09

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD, welcome Dr. Shunsuke Uetake of Nippon Medical School Chiba Hokusoh Hospital to discuss the clinical presentation and long-term outcomes of late-onset symptomatic arrhythmogenic right ventricular cardiomyopathy (ARVC), based on a retrospective cohort study recently published in JACC: Clinical Electrophysiology. Dr. Uetake reviews findings from 76 probands with definite ARVC by 2010 Task Force criteria who presented with symptomatic

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18:37

ESC Day 4 – JACC SimPub Spotlight | JACC Baran

JACC Global ·

2025/09/01

Mitsuaki Sawano, MD, with Nobuhiro Ikemura, MD highlight two JACC papers simultaneously published at ESC 2025. “Comparison of Extended Cryoballoon Ablation, Standard Cryoballoon Ablation, and Radiofrequency Catheter Ablation in Patients with Persistent AF (EXCAPE-AF Trial)” – In persistent AF, extended CB with posterior wall isolation offered no benefit over standard CB or RF, underscoring PVI as central. 2nd paper titled “Impact of Obicetrapib on Major Adverse Cardiovascular Events in High-Risk

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14:48

ESC Day 3–JACC SimPub Spotlight | JACC Baran

JACC Global ·

2025/08/31

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Satoshi Shoji, MD, highlight two JACC papers simultaneously published at ESC 2025. Computed Tomography Angiography or Standard of Care after Left Main PCI? The PULSE Trial tested routine CCTA follow-up versus symptom- or ischemia-driven management after LM PCI. While the primary composite outcome showed no difference, CCTA reduced spontaneous MI but increased imaging-driven revascularization. The Adipokine Hypothesis of Heart Failure With a Preserved

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