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PODCAST

JACC Global

American College of Cardiology

Explore cardiovascular science from a global perspective with JACC Global. This podcast highlights original research, regional innovations, and urgent challenges in heart health across diverse healthcare settings worldwide.

health & fitness medicine

All Episodes

19:47

Chagas Cardiomyopathy — Epidemiology Through Modern...

JACC Global ·

2026/04/07

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Nobuhiro Ikemura, MD welcome Dr. Ryohei Ono, MD, PhD (University of Glasgow / Chiba University) to discuss his simultaneously published JACC study analyzing over 23,000 patients from global HFrEF trials. Once considered regional, Chagas cardiomyopathy is now a global concern. This episode highlights its consistently higher risks of cardiovascular death, heart failure hospitalization, and stroke compared with other etiologies, and explores how etiology

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21:02

Japanese Circulation Society 2026 Special — JACC at...

JACC Global ·

2026/04/01

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Nobuhiro Ikemura, MD welcome Dr. Kanna Nakamura, MD and Dr. Yugo Yamashita, MD (Kyoto University) to discuss their Late Breaking Clinical Cohort presented at the 2026 JCS in Fukuoka, exploring venous thromboembolism (VTE) risk prediction in cancer patients using comprehensive genomic profiling. In a cohort of patients undergoing cancer genomic panel testing, 14.3% developed VTE over a median follow-up of ~2 years. Specific gene mutations—including

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36:18

Mild PVR in TAVR — A Small Leak, Long-Term Impact |...

JACC Global ·

2026/03/24

Hosts Mitsuaki Sawano, MD, and Kentaro Ejiri, MD welcome Dr. Yusuke Watanabe, MD (Teikyo University) to discuss his study from the OCEAN-TAVI Registry, examining the long-term impact of mild paravalvular regurgitation (PVR) after TAVR. In over 5,000 patients with up to 9 years of follow-up, mild PVR—traditionally considered clinically acceptable—was associated with higher risks of all-cause mortality and bioprosthetic valve failure (BVF). Even modest regurgitation appeared to have cumulative effects

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35:59

LDH in HFrEF — A Common Test, A Hidden Signal | JACC...

JACC Global ·

2026/03/17

Hosts Mitsuaki Sawano, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD welcome Dr. Ryohei Ono, MD, PhD (BHF Cardiovascular Research Centre, University of Glasgow / Chiba University) to discuss his JACC: Heart Failure study, “Lactate Dehydrogenase and Outcomes in Patients With HFrEF: Insights From GALACTIC-HF.” The episode explores how LDH—one of the most commonly measured laboratory tests—may be a hidden gem for prognostication, reflecting systemic hypoperfusion and multiorgan stress in patients

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26:56

TAVR and HFrEF — Are We Fully Applying GDMT? | JACC...

JACC Global ·

2026/03/10

Hosts Mitsuaki Sawano, MD, and colleagues welcome Dr. Yusuke Kobari, MD, PhD (Heart Center, Copenhagen) to discuss his recent publication in JACC: Cardiovascular Interventions, “Clinical Application of Guideline-Directed Medical Therapy in TAVR Patients With Heart Failure and Reduced Ejection Fraction.” Among 336 patients with LVEF ≤40%, most were eligible for quadruple HF therapy, yet only 27% received it by 3 months. Patients on more complete GDMT had lower 2-year rates of cardiovascular death or

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42:55

TR and AFib After M-TEER: A Risk Interaction to Watch...

JACC Global ·

2026/03/03

Hosts Mitsuaki Sawano, MD, Nobu Ikemura, MD, and Satoshi Shoji, MD welcome Dr. Shingo Matsumoto, MD (Toho University) and Dr. Yohei Ohno, MD (Tokai University) to discuss their JACC: Cardiovascular Interventions study, “Atrial Fibrillation and Tricuspid Regurgitation in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair.” Building on prior evidence that residual tricuspid regurgitation (TR) influences outcomes after M-TEER, this analysis examines how atrial fibrillation (AF)

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30:53

HFpEF: Normal by Echo, Abnormal by Hemodynamics |...

JACC Global ·

2026/02/23

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Tomonari Harada, MD, PhD (Mayo Clinic / Gunma University) with commentary from Dr. Masaru Obokata, MD (Gunma University) to discuss their JACC study, “Echocardiographic Diastolic Function Grading in HFpEF: Testing the Updated 2025 ASE Criteria.” This investigation applies the newly updated 2025 ASE diastolic function grading algorithm to invasively confirmed HFpEF cohorts and examines how frequently patients may be classified as “Normal”

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37:15

Cardiac Sarcoidosis Beyond Suppression: Imaging and...

JACC Global ·

2026/02/17

Hosts Mitsuaki Sawano, MD, and Kentaro Ejiri, MD, welcome Dr. Yusuke Nakashima, MD (Yamaguchi University) and Prof. Shigeki Kobayashi , MD(Yamaguchi University) to discuss their study published in JACC: Cardiovascular Imaging, exploring prognostic markers in patients with cardiac sarcoidosis following steroid therapy. Focusing on a condition in which clinical stability does not always equate to low risk, this episode examines how residual myocardial inflammation on FDG-PET and oxidative stress

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32:17

Coronary Revascularization in the Real World:...

JACC Global ·

2026/02/10

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Shun Kohsaka, MD (Keio University School of Medicine) and Prof. Noboru Motomura, MD (Toho University Sakura Medical Center) to discuss their JACC study examining nationwide trends in coronary revascularization across Japan. Using two of the country’s largest all-Japan registries—the J-PCI registry and the JCVSD—this analysis tracks how PCI and CABG volumes evolved from a steady decline to a post-2020 plateau, amid major external influences

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24:48

What Spontaneous Echo Contrast Reveals After Left...

JACC Global ·

2026/02/03

Host Mitsuaki Sawano welcomes Dr. Sachiyo Ono, MD (Department of Cardiology, Kurashiki Central Hospital; Minneapolis Heart Institute Foundation International Scholar) to discuss her JACC: Clinical Electrophysiology study from the OCEAN-LAAC registry. Focusing on patients undergoing Left Atrial Appendage Closure, this episode explores how Spontaneous Echo Contrast (SEC)—particularly when combined with persistent atrial fibrillation—relates to thromboembolic events and device-related thrombosis after

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34:24

Too Old for Ablation? Insights from AF Patients Aged...

JACC Global ·

2026/01/27

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, Nobu Ikemura, MD, and Satoshi Shoji, MD welcome Dr. Shu Hirata, MD (Department of Cardiology, Nihon University Itabashi Hospital), with guest commentary from Dr. Hiroyuki Sato, MD (Tohoku University), to discuss the REHEALTH-AF Study published in JACC: Clinical Electrophysiology. Focusing on patients aged 80 years and older with atrial fibrillation—a group often underrepresented in research and less frequently considered for catheter ablation in routine

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40:21

Japan’s Cardiovascular Playbook: A Living History...

JACC Global ·

2026/01/20

Hosts Mitsuaki Sawano, MD, Shun Kohsaka, MD, and Satoshi Shoji, MD welcome Prof. Tomonori Okamura, MD, and Dr. Aya Hirata, MPH, PhD (Department of Preventive Medicine and Public Health, Keio University School of Medicine) to discuss their JACC Viewpoint, “Current Status of Cardiovascular Disease in Japan: Prevention Strategies, Future Challenges, and Fundamental Lessons.” Building on the Global Burden of Disease (GBD) 2023 analysis featured in Epi 40, this episode explores why Japan has achieved one

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29:36

M-TEER: Challenging the Status Quo With...

JACC Global ·

2026/01/13

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Hiroshi Tsunamoto to discuss his JACC study from the OCEAN-Mitral Registry, examining how transmitral pressure gradients (TMPG) and residual mitral regurgitation (MR) jointly determine outcomes after transcatheter edge-to-edge repair (M-TEER) for functional MR. In over 2,300 patients, higher postprocedural TMPG (≥5 mmHg) was consistently associated with worse 2-year outcomes, regardless of residual MR severity, while patients achieving MR

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37:15

PREVENT in East Asia: Can One Risk Score Fit All? |...

JACC Global ·

2026/01/06

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Prof. Kosuke Inoue (Kyoto University) and Dr. Yuichiro Mori (Kyoto University) to discuss their JACC Brief Report, “Evaluation of the PREVENT Equations in a Nationwide Cohort of 7.7 Million Korean Adults.” Using one of the world’s largest national health databases, the study externally validates the AHA-developed PREVENT risk equations in an East Asian population, showing good discrimination and calibration for ASCVD, outperforming the

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34:38

“Just One Drink?” Think Again — Blood Pressure Says...

JACC Global ·

2025/12/23

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, welcome Dr. Takahiro Suzuki to discuss his JACC paper, “Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis.” Using a two-cohort design—cessation among habitual drinkers and initiation among nondrinkers—the study demonstrates dose-dependent blood pressure effects when alcohol intake is reduced or begun, and importantly fills a major evidence gap for women and for

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29:00

CT-Based Plaque Norms: Rethinking Risk in Healthy...

JACC Global ·

2025/12/16

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, and Satoshi Shoji, MD welcome Dr. Keishi Ichikawa, MD (Lundquist Institute at Harbor–UCLA) to discuss his JACC: Cardiovascular Imaging study from the Miami Heart Study, defining the population norms of coronary plaque using AI-based coronary CT angiography. In 2,301 asymptomatic adults, AI detected plaque in nearly 9 out of 10 individuals —providing age- and sex-specific nomograms for calcified and noncalcified plaque. The episode explores how these data

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38:43

Leave Nothing Behind: The Current and Future of...

JACC Global ·

2025/12/09

Hosts Mitsuaki Sawano, MD, Nobuhiro Ikemura, MD, and Satoshi Shoji, MD welcome Prof. Yoshinobu Onuma (University of Galway)—Last Author of the ARC Position Statement—along with guest commentators Prof. Ken Kozuma (Teikyo University) and Dr. Taku Asano (St. Luke’s International Hospital) to discuss the evolving role of drug-coated balloons (DCBs) in coronary intervention. The conversation highlights key insights from the ARC document, including DCB technology classifications, drug and coating

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31:09

A Global Look at Heart Disease: What the GBD Study...

JACC Global ·

2025/12/02

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Prof. Shuhei Nomura, PhD (Tohoku University) for an in-depth discussion of the landmark JACC Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2023 analysis, covering data from 204 countries and territories. Dr. Nomura, a leading member of the Global Burden of Disease (GBD) collaboration, explains how cardiovascular disease—still largely preventable—now accounts for an increasing share of global health loss, with metabolic risks

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29:21

Ten Seconds That Matter: Clinical Frailty Scale in...

JACC Global ·

2025/11/25

Hosts Mitsuaki Sawano, MD, and Nobuhiro Ikemura, MD, welcome Dr. Taisuke Nakade (Juntendo University) and Dr. Yuya Matsue (Juntendo University) to discuss how a simple Clinical Frailty Scale (CFS) captures multidimensional vulnerability and predicts outcomes in heart failure. Drawing on 3,905 patients (mean age 73 years) from the nationwide JROAD-HF NEXT registry, the JACC study (Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure, 2025;

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36:10

When MRI Falls Short: ICE Identifies Arrhythmogenic...

JACC Global ·

2025/11/18

Hosts Mitsuaki Sawano, MD, Kentaro Ejiri, MD, Nobuhiro Ikemura and Satoshi Shoji, MD, welcome Naohiko Sahara, MD (Toho University Ohashi Medical Center) to discuss his JACC: Clinical Electrophysiology study on intracardiac echocardiography (ICE) for detecting periaortic ventricular tachycardia substrate. In a multimodality core lab analysis, Dr. Sahara showed that ICE outperformed cardiac MRI in identifying arrhythmogenic scars, with wall thinning <0.6 cm predicting substrate even when no LGE was

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