PODCAST

Life sciences knowledge center

Echo Han

science life sciences

All Episodes

00:10:09

Oncolytic Virus Construction

Life sciences knowledge center ·

2023/05/08

Oncolytic Virus ConstructionAdenovirus has been explored and engineered extensively as an oncolytic virus and viral vector for gene therapy to reduce viral virulence and increase efficacy and specificity. E1A gene in adenovirus is responsible for viral replication in tumor cells and needs to be attenuated for oncolytic purpose. Coated protein modification is to increase target specificity of adenovirus to tumor cells, and thus alters viral tropism. Adenovirus can also be modified through

en-us

00:10:09

Oncolytic Virus in vitro Validation Study

Life sciences knowledge center ·

2023/05/08

en-us

00:10:09

Oncolytic Virus Basis

Life sciences knowledge center ·

2023/05/08

Oncolytic Virus Basis The strategy implementation of immunotherapeutic for the treatment of cancer has gained prominence over the past decade in preclinical development and clinical practice. Traditional oncological treatments, including surgery, radiation, and chemotherapy, aim to directly remove or kill cancer cells, but receive high probability of recurrences or serious side effects. In contrast, immunotherapy seeks to enhance the host immune system's ability to eliminate cancer cells,

en-us

00:10:09

Oncolytic Virotherapy Development for Combination...

Life sciences knowledge center ·

2023/05/08

Oncolytic Virotherapy Development for Combination Therapy with Cancer Vaccines Oncolytic virotherapy (OV) represents an exciting new area of cancer treatment by exploiting a virus's ability to selectively replicate and kill tumor tissue while stimulating a patient-specific immune response against cancer.

en-us

00:10:09

Cytokine/Chemokine-expressing Oncolytic Virus

Life sciences knowledge center ·

2023/05/08

Cytokine/Chemokine-expressing Oncolytic Virus Genetic therapies, such as transfected viral vectors and immune cells, continue to display clinical responses as systemically deliverable and targeted therapeutics, with the first such strategy having been approved for cancer treatment.

en-us

00:10:09

Oncolytic Virus Efficacy Study

Life sciences knowledge center ·

2023/05/08

The currently approved oncolytic virus drugs and different clinical trials have proved promising efficacy data. Preclinical study of in vivo efficacy will provide more powerful information for later stage development, including optimization of administration route, dose, and clinical trial design.

en-us

00:10:09

Cytokine/Chemokine-expressing Oncolytic Virus

Life sciences knowledge center ·

2023/05/08

Genetic therapies, such as transfected viral vectors and immune cells, continue to display clinical responses as systemically deliverable and targeted therapeutics, with the first such strategy having been approved for cancer treatment.

en-us

00:10:09

Oncolytic Virus in vitro Validation Study

Life sciences knowledge center ·

2023/05/08

Oncolytic virus is engineered by homologous recombination from parental virus. The recombination rate is low and parental virus has growth superiority. In order to get purified engineered oncolytic virus, several rounds of plaque purification must be performed. Scientist in Creative Biolabs has developed optimal method to do the plaque purification assay for oncolytic virus engineering.

en-us

00:10:09

Oncolytic Virus Combination Therapies-with...

Life sciences knowledge center ·

2023/05/08

Tumor radiotherapy is a local treatment method that uses radiation to treat tumors. Radiation includes α, β, and γ rays generated by radioisotopes and x-rays, electron beams, proton beams, and other particle beams generated by various x-ray therapy machines or accelerators. The history of radiotherapy is only a few decades, but with the help of the development of CT imaging technology and computer technology, it has developed from two-dimensional radiotherapy to three-dimensional or even

en-us

00:11:48

IVT mRNA

Life sciences knowledge center ·

2023/04/06

With the development of IVT methods, synthetic mRNA has become an emerging class of gene therapy. IVT mRNA has several advantages, such as the mRNA does not require nuclear localization to mediate protein translation. The intracellular process for protein expression is much simpler, and the level of protein expression is far enhanced. IVT mRNA can be produced in large-scale amounts in GMP quality, allowing the clinical application of mRNA-based therapies. Due to its safety and high efficiency, IVT

en-us

00:11:48

mRNA technology company

Life sciences knowledge center ·

2023/04/06

In the past few years, mRNA has been considered as a powerful tool for treating a wide variety of human diseases, especially for malignant tumors. Up to now, a wide collection of mRNA-based studies, including in silico mRNA structure analysis, mRNA synthesis, mRNA modification, mRNA delivery, mRNA-based cell reprogramming, and mRNA stability test, has aroused much attention due to the essential role of mRNA in disease therapy.https://mrna.creative-biolabs.com/

en-us

00:11:48

mRNA molecule

Life sciences knowledge center ·

2023/04/06

Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. This pre-mRNA will be further processed into mature mRNA by RNA splicing and

en-us

00:11:48

Antibody mRNA

Life sciences knowledge center ·

2023/04/06

Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence

en-us

00:11:48

Cytokine mRNA

Life sciences knowledge center ·

2023/04/06

Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors.https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm

en-us

00:11:48

In vitro transcription vector

Life sciences knowledge center ·

2023/04/06

mRNA has become an emerging class of gene therapy because of its negligible cytotoxicity and immunogenicity. So, there is an increasing demand for efficient and robust production of mRNA molecules in both pharmaceutics and research field. In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides.https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm

en-us

00:11:48

mRNA products

Life sciences knowledge center ·

2023/04/06

reagents for mRNA delivery, genome editing mRNA, reporter gene mRNA, growth factor mRNA, mRNA kits, enzymes for mRNA research, and nucleotide products for mRNA research https://mrna.creative-biolabs.com/category-mrna-products-443.htm

en-us

00:11:48

mRNA Chemical Synthesis

Life sciences knowledge center ·

2023/04/06

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time. However, mRNA prepared with enzymatic synthesis may present transcriptional errors, which can only be produced at a laboratory scale, and products may not pure enough for the intended use.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm

en-us

00:11:48

synthetic mRNA

Life sciences knowledge center ·

2023/04/06

en-us

00:12:01

iPS Cell Reprogramming by mRNA

Life sciences knowledge center ·

2023/04/06

Non-integrative mRNA reprogramming has proven to be the most efficient and clinically-relevant method for human induced pluripotent stem cells (iPSCs) reprogramming.https://mrna.creative-biolabs.com/custom-ips-cell-reprogramming-by-mrna.htm

en-us

00:10:54

mRNA molecule

Life sciences knowledge center ·

2023/03/05

Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm

en-us

203 results

Life sciences knowledge center

All Episodes

Similar Podcasts

X Minus 1 - Old Time Radio Show

Inception Point Ai

Science, Spoken

WIRED

This Week in Space (Audio)

TWiT

DarshanTalks Podcast

Darshan Kulkarni

The Best of Coast to Coast AM

iHeartPodcasts and Coast to Coast AM