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PODCAST

Health Longevity Secrets

Robert Lufkin MD

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe

health & fitness medicine

All Episodes

48:37

What Is Next After the Apple Watch?

Health Longevity Secrets ·

2025/12/09

What if you could see your inflammation—and your pace of aging—from your kitchen table? We sit down with Bob Messerschmidt, an optical engineer turned Apple platform architect who helped seed Apple Health and the Apple Watch, then left to build a simple at-home device that measures ESR, a century‑old inflammation marker with fresh relevance for longevity. We unpack why chronic inflammation drives heart disease, stroke, neurodegeneration, and metabolic dysfunction, and why a single, trackable...

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49:15

The Cookbook That Saved My Life

Health Longevity Secrets ·

2025/12/02

What if everything you've been taught about nutrition is not just wrong, but actively harming your health? Cary Kelly's story might make you question your most basic assumptions about food and wellness. Cary grew up in a household religiously following conventional dietary guidelines—low-fat everything, margarine instead of butter, minimal red meat, and plenty of "heart-healthy" grains. Yet by his late 40s, his health was deteriorating rapidly. Chronic inflammation ravaged his body, extra we...

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11:15

How to Survive The Holiday Air Travel

Health Longevity Secrets ·

2025/11/25

Holiday flights don’t have to flatten your energy or your immune system. Dr. Robert Lufkin breaks down what actually happens to your body at altitude—lower oxygen, desert-dry cabins, stalled circulation—and shares a clear plan to stay sharp before, during, and after you fly. Instead of white-knuckling through recycled air and jet lag, you’ll learn how to turn the cabin into a controllable environment and land clear, not crushed. We start with the physiology: why pressurization strains mitoch...

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44:50

What If Sugar Wasn't Sweet?

Health Longevity Secrets ·

2025/11/18

Cravings aren’t just about weak will; they’re biology doing exactly what billions of food dollars engineered them to do. We sit down with Sander Brus to unpack how sweetness hijacks reward circuits, why kids are showing up with adult metabolic diseases, and what happens when you flip the switch on sweet taste itself. Sander takes us from his diagnostics background into the heart of metabolic health, explaining how sweet taste receptors (T1R2/T1R3) live on the tongue and in the gut, where the...

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48:24

Keto for Cancer?

Health Longevity Secrets ·

2025/11/11

What if the real action in cancer isn’t in the genome, but upstream in the mitochondria and the metabolic “terrain” that shapes every signal your cells send and receive? We sit down with Dr Nasha Winters to rethink cancer as an ecologic disease and explore how shifting the terrain can change outcomes without rejecting standard care. We dig into why ketones are more than fuel. Nasha explains how a therapeutic ketotic state—reached through fasting, carb restriction, or exogenous support—can lo...

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53:21

DMT: Death By Astonishment with Andrew Gallimore

Health Longevity Secrets ·

2025/11/04

Imagine your brain as a world-building engine that never shows you the thing-in-itself, only a model tuned for survival. Now imagine a molecule that doesn’t just bend that model but switches it to a fully formed, hyper-detailed reality populated by entities that seem to think, act, and sometimes deny you entry. That’s the claim at the heart of our conversation with computational neurobiologist and DMT researcher Andrew Gallimore, author of Death by Astonishment. We start by laying the ground...

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40:28

A Facelift Without A Scar?

Health Longevity Secrets ·

2025/10/28

A facelift without a telltale ear scar sounds like sci‑fi—until you hear how Dr. Mark Mani designed it. We sit down with the Beverly Hills surgeon, artist, and inventor to explore how endoscopic deep‑plane lifting repositions the face where gravity actually acts, delivering natural contour without the stigma of visible incisions. Mark traces the decade it took to refine the approach, publish the first academic description, and train surgeons worldwide, and he explains why subtle, anatomically...

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39:46

The Skin Creme That Nearly Killed Me

Health Longevity Secrets ·

2025/10/21

A world champion athlete shouldn’t have to fight for the right diagnosis—yet Kelly Palace did, for years. What began as a swimmer’s quick fix for itchy, chlorine-dry skin became a descent into topical steroid addiction and withdrawal: spreading rashes, burning, oozing skin, misdiagnoses, and the long, lonely road of recovery. Kelly lays out the unvarnished truth about a “miracle cream” millions use and why the industry’s strongest selling points—fast relief and flawless skin—can mask a deeper...

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43:01

How to Fast Without Fasting

Health Longevity Secrets ·

2025/10/14

What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible. During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways,...

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36:35

Will My Shirt Make Me Healthy?

Health Longevity Secrets ·

2025/10/07

What if the clothes you wear and the sheets you sleep on could actively improve your health without you doing a thing? In this fascinating conversation, Seth Casden introduces us to a truly passive biohacking tool that's hiding in plain sight. Technology transforms ordinary fabrics into wellness tools by embedding them with micron-sized minerals that capture body heat and convert it into beneficial infrared light. This light penetrates the skin and increases local circulation, delivering mor...

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49:09

Sex, Power, Suicide, and Mitochondria with Dr Natalie...

Health Longevity Secrets ·

2025/09/30

What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death. Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how thes...

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47:50

Does Mouthwash Cause Hypertension? with Dr Nathan Bryan

Health Longevity Secrets ·

2025/09/23

Ever wondered how a single molecule can regulate blood flow, support neurotransmission, and boost immune defense? Dr. Bryan unravels these mysteries and cuts through the confusion with nitrous oxide, sharing invaluable insights from his collaborations with Nobel Prize winners. Join us as we explore why nitric oxide is pivotal to our health and longevity, and why it deserves more attention in medical circles. We also probe into the darker side of proton pump inhibitors (PPIs) and their detrim...

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47:11

Stop Overdosing Ozempic! with Dr Tyna Moore

Health Longevity Secrets ·

2025/09/16

GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management. When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from ...

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47:10

Keto = Death? with Dr Dom D'Agostino

Health Longevity Secrets ·

2025/09/09

Ready to revolutionize your understanding of metabolism? Dr. Dominic D'Agostino takes us deep into the science of ketosis, revealing why this evolutionary metabolic state might be the missing link in our modern health crisis. The keto revolution isn't just about weight loss. As Dr. Dom explains, ketosis fundamentally changes our physiology in ways that impact every major system in our body. While our ancestors regularly shifted in and out of this fat-burning state, most modern humans never e...

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40:52

Lasers vs Painkillers: Deep-dive into Photobiomodulation

Health Longevity Secrets ·

2025/09/02

Guest: Forrest Smith — serial founder bringing clinic-grade photobiomodulation to a safe, wearable form factor. Theme: Why dose and delivery matter more than raw wattage for red light therapy. Key takeaways Wavelengths that work: Deep red 660 nm (blood flow, NO release, shallow penetration) + 808 nm near-IR (deeper tissues/joints).Mechanisms: Hemoglobin photodissociates NO → vasodilation + better O₂ delivery; mitochondria’s cytochrome c oxidase bottleneck relieved → higher ATP output; downst...

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48:08

Cancer Isn’t Genetic: It's Real Root Causes

Health Longevity Secrets ·

2025/08/26

Cancer isn’t just random genetic mutations. It doesn’t “just happen.” In this episode, Dr. Connealy pulls back the curtain on what really drives cancer — from mitochondrial breakdown and hidden toxins to stress, parasites, and even low voltage inside your cells. You’ll learn how to hack your environment, strengthen your biology, and prevent disease years before a tumor ever shows up on a scan. Dr. Leigh Erin Connealy, MD, is one of the most sought-after integrative oncologists in the wo...

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43:18

The Anti-Aging Molecule You're Missing for Hair...

Health Longevity Secrets ·

2025/08/19

What if one natural molecule could reverse key signs of aging, repair your immune system, grow your hair, and even help you sleep better? In this episode, Robert Lufkin, MD, sits down with Leslie Kenny, a patient advocate with a remarkable story. At 39, she was told she had only 5 years to live with lupus and rheumatoid arthritis. Instead, through lifestyle changes and a breakthrough discovery about spermidine, she now enjoys extraordinary health — with a biological age of just 21 at age 60. ...

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41:59

Is Rapamycin the Best Longevity Drug? with Dr Rick Cohen

Health Longevity Secrets ·

2025/08/12

Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair. This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available i...

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40:42

Is Bioidentical Hormone Replacement: The Missing...

Health Longevity Secrets ·

2025/08/05

What if the key to feeling better at 45 than you did at 25 isn't about accepting "normal" lab values, but about optimizing your hormones to their ideal levels? In this eye-opening conversation, Dr. Lauren Fitzgerald—a board-certified anesthesiologist who now specializes in bioidentical hormone replacement therapy—challenges conventional medical wisdom about hormone health. Dr. Fitzgerald breaks down the critical difference between bioidentical hormones and non-bioidentical versions. This dis...

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33:09

Why Measure Erections?

Health Longevity Secrets ·

2025/07/29

Unlock the secrets of male well-being with Christos Konstantinidis, the pioneering founder and CEO of Adam Health, as we unveil the profound link between erectile health and holistic male wellness. Discover how your body's signals, often overlooked, could be the earliest indicators of serious health concerns like cardiovascular disease. Christos provides enlightening insights into how erectile function serves as a critical health barometer, cutting across cardiovascular, neurological, and hor...

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236 results

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