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PODCAST

Health Longevity Secrets

Robert Lufkin MD

A podcast to transform your health and longevity with evidence-based lifestyle modifications and other tools to prevent and even reverse the most disruptive diseases. We feature topics including longevity, fasting, ketosis, biohacking, Alzheimer’s disease, heart disease, stroke, cancer, consciousness, and much more so that you can find out the latest proven methods to optimize your life. It’s a mix of interviews, special co-hosts, and solo shows that you’re not going to want to miss. Hit subscribe

health & fitness medicine

All Episodes

40:28

A Facelift Without A Scar?

Health Longevity Secrets ·

2025/10/28

A facelift without a telltale ear scar sounds like sci‑fi—until you hear how Dr. Mark Mani designed it. We sit down with the Beverly Hills surgeon, artist, and inventor to explore how endoscopic deep‑plane lifting repositions the face where gravity actually acts, delivering natural contour without the stigma of visible incisions. Mark traces the decade it took to refine the approach, publish the first academic description, and train surgeons worldwide, and he explains why subtle, anatomically...

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39:46

The Skin Creme That Nearly Killed Me

Health Longevity Secrets ·

2025/10/21

A world champion athlete shouldn’t have to fight for the right diagnosis—yet Kelly Palace did, for years. What began as a swimmer’s quick fix for itchy, chlorine-dry skin became a descent into topical steroid addiction and withdrawal: spreading rashes, burning, oozing skin, misdiagnoses, and the long, lonely road of recovery. Kelly lays out the unvarnished truth about a “miracle cream” millions use and why the industry’s strongest selling points—fast relief and flawless skin—can mask a deeper...

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43:01

How to Fast Without Fasting

Health Longevity Secrets ·

2025/10/14

What if you could enjoy all the powerful health benefits of fasting without actually going hungry? Dr. Chris Rhodes, a biochemist with a PhD from UC Davis, has discovered a revolutionary approach that might make this possible. During this fascinating conversation, Dr. Rhodes explains how fasting triggers a remarkable survival response in our cells. After about 24 hours without food, our bodies deplete glycogen stores and enter "true fasting metabolism," activating anti-inflammatory pathways,...

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36:35

Will My Shirt Make Me Healthy?

Health Longevity Secrets ·

2025/10/07

What if the clothes you wear and the sheets you sleep on could actively improve your health without you doing a thing? In this fascinating conversation, Seth Casden introduces us to a truly passive biohacking tool that's hiding in plain sight. Technology transforms ordinary fabrics into wellness tools by embedding them with micron-sized minerals that capture body heat and convert it into beneficial infrared light. This light penetrates the skin and increases local circulation, delivering mor...

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49:09

Sex, Power, Suicide, and Mitochondria with Dr Natalie...

Health Longevity Secrets ·

2025/09/30

What if the secret to treating age-related diseases and extending healthy lifespan lies within tiny cellular structures that evolved from ancient bacteria? In this mind-expanding conversation, biochemist Dr. Natalie Yivgi-Ohana reveals how mitochondria—far more than mere cellular powerhouses—control everything from hormone production to programmed cell death. Dr. Yivgi-Ohana, founder of Minovia Therapeutics, takes us on a fascinating journey through mitochondrial science, explaining how thes...

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47:50

Does Mouthwash Cause Hypertension? with Dr Nathan Bryan

Health Longevity Secrets ·

2025/09/23

Ever wondered how a single molecule can regulate blood flow, support neurotransmission, and boost immune defense? Dr. Bryan unravels these mysteries and cuts through the confusion with nitrous oxide, sharing invaluable insights from his collaborations with Nobel Prize winners. Join us as we explore why nitric oxide is pivotal to our health and longevity, and why it deserves more attention in medical circles. We also probe into the darker side of proton pump inhibitors (PPIs) and their detrim...

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47:11

Stop Overdosing Ozempic! with Dr Tyna Moore

Health Longevity Secrets ·

2025/09/16

GLP-1 agonists are transforming medicine in ways few could have predicted. In this captivating conversation, naturopathic physician Dr. Tina Moore challenges the conventional narrative around these medications, revealing their potential beyond weight loss and diabetes management. When Dr. Tina first began researching GLP-1s, she discovered a wealth of overlooked studies showing profound effects on inflammation, autoimmunity, and regenerative healing. Despite facing significant pushback from ...

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47:10

Keto = Death? with Dr Dom D'Agostino

Health Longevity Secrets ·

2025/09/09

Ready to revolutionize your understanding of metabolism? Dr. Dominic D'Agostino takes us deep into the science of ketosis, revealing why this evolutionary metabolic state might be the missing link in our modern health crisis. The keto revolution isn't just about weight loss. As Dr. Dom explains, ketosis fundamentally changes our physiology in ways that impact every major system in our body. While our ancestors regularly shifted in and out of this fat-burning state, most modern humans never e...

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40:52

Lasers vs Painkillers: Deep-dive into Photobiomodulation

Health Longevity Secrets ·

2025/09/02

Guest: Forrest Smith — serial founder bringing clinic-grade photobiomodulation to a safe, wearable form factor. Theme: Why dose and delivery matter more than raw wattage for red light therapy. Key takeaways Wavelengths that work: Deep red 660 nm (blood flow, NO release, shallow penetration) + 808 nm near-IR (deeper tissues/joints).Mechanisms: Hemoglobin photodissociates NO → vasodilation + better O₂ delivery; mitochondria’s cytochrome c oxidase bottleneck relieved → higher ATP output; downst...

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48:08

Cancer Isn’t Genetic: It's Real Root Causes

Health Longevity Secrets ·

2025/08/26

Cancer isn’t just random genetic mutations. It doesn’t “just happen.” In this episode, Dr. Connealy pulls back the curtain on what really drives cancer — from mitochondrial breakdown and hidden toxins to stress, parasites, and even low voltage inside your cells. You’ll learn how to hack your environment, strengthen your biology, and prevent disease years before a tumor ever shows up on a scan. Dr. Leigh Erin Connealy, MD, is one of the most sought-after integrative oncologists in the wo...

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43:18

The Anti-Aging Molecule You're Missing for Hair...

Health Longevity Secrets ·

2025/08/19

What if one natural molecule could reverse key signs of aging, repair your immune system, grow your hair, and even help you sleep better? In this episode, Robert Lufkin, MD, sits down with Leslie Kenny, a patient advocate with a remarkable story. At 39, she was told she had only 5 years to live with lupus and rheumatoid arthritis. Instead, through lifestyle changes and a breakthrough discovery about spermidine, she now enjoys extraordinary health — with a biological age of just 21 at age 60. ...

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41:59

Is Rapamycin the Best Longevity Drug? with Dr Rick Cohen

Health Longevity Secrets ·

2025/08/12

Dive into the fascinating world of longevity research as we explore rapamycin, potentially the most powerful anti-aging pharmaceutical currently known. Dr. Rick Cohen, longevity physician with over 25 years of experience, reveals how this natural molecule discovered on Easter Island targets a fundamental cellular pathway called mTOR that acts as our body's metabolic switch between growth and repair. This episode is sponsored by Gatlan who makes rapamycin that we will be discussing available i...

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40:42

Is Bioidentical Hormone Replacement: The Missing...

Health Longevity Secrets ·

2025/08/05

What if the key to feeling better at 45 than you did at 25 isn't about accepting "normal" lab values, but about optimizing your hormones to their ideal levels? In this eye-opening conversation, Dr. Lauren Fitzgerald—a board-certified anesthesiologist who now specializes in bioidentical hormone replacement therapy—challenges conventional medical wisdom about hormone health. Dr. Fitzgerald breaks down the critical difference between bioidentical hormones and non-bioidentical versions. This dis...

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33:09

Why Measure Erections?

Health Longevity Secrets ·

2025/07/29

Unlock the secrets of male well-being with Christos Konstantinidis, the pioneering founder and CEO of Adam Health, as we unveil the profound link between erectile health and holistic male wellness. Discover how your body's signals, often overlooked, could be the earliest indicators of serious health concerns like cardiovascular disease. Christos provides enlightening insights into how erectile function serves as a critical health barometer, cutting across cardiovascular, neurological, and hor...

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54:07

Does Mitochondrial Transplantation Work?

Health Longevity Secrets ·

2025/07/22

What if we could reset our cellular batteries? In this fascinating deep dive into cutting-edge longevity science, Tom Benson from Mitrix Bio reveals how mitochondrial transplantation could revolutionize how we treat age-related diseases and potentially add decades of healthy living to our lives. The conversation begins by exploring the extraordinary nature of mitochondria – those tiny power plants within our cells that generate 95% of our body's energy through molecular rotors functioning li...

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46:41

Oral Testosterone For Better Health with Dr Andrew Sun

Health Longevity Secrets ·

2025/07/15

Curious about the real power of testosterone beyond the realm of bodybuilding? Join us as we sit down with Dr Andrew Sun, a fellowship-trained andrology specialist, who unpacks the diverse roles this crucial hormone plays in men's health. Discover the surprising factors, like poor sleep and metabolic syndrome, that can lower testosterone levels even in younger men. Andrew guides us through the significance of testosterone replacement therapy, not as a vanity metric but as a doorway to enhanci...

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50:05

The Power of Functional Medicine with Dr. Mark Hyman

Health Longevity Secrets ·

2025/07/08

Ever wondered if you can truly turn back the clock on aging? Join us in this compelling episode as Dr. Mark Hyman shares his extraordinary insights on the power of functional medicine to rejuvenate the body and mind at any age. Discover how Dr. Hyman's personal and professional journey led him to uncover the foundational causes of aging and chronic disease, and learn about the vital distinctions between beneficial and harmful stress. We also delve into the fascinating concept of biological ve...

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40:05

Stem Cells For Longevity with Dr Vincent Giampapa

Health Longevity Secrets ·

2025/07/01

This week we are broadcasting a fascinating presentation from my good friend Dr Vincent Giampapa where he discusses the potential and actual use of stem cell therapy for longevity. I have had the pleasure of visiting his remarkable longevity center in San Jose Costa Rica. We will be having a dedicated upcoming episode about it. This presentation is from the most recent RAADFEST meeting which is set to take place again in Las Vegas on July 10-13. You won't want to miss it! https://www.ra...

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62:20

Spermidine: The Autophagy Activator with Dr Melissa Cano

Health Longevity Secrets ·

2025/06/24

As we near the end of the school year, I'd like to give a shoutout to Mr George Gaskin's 7th grade history class at Harvard-Westlake School who are fans of this program. Have you ever wondered what keeps your cells functioning properly? The answer might be a molecule with a funny name but serious implications for longevity. Spermidine, found in every living cell on Earth, is essential for triggering autophagy—your body's internal cleaning system that recycles damaged cellular components...

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44:37

How Food Affects Mental Health with Dr Christopher...

Health Longevity Secrets ·

2025/06/17

Dr. Christopher Palmer is a friend and regular guest on this program and he never disappoints. This week he takes us on a fascinating journey through the groundbreaking connection between metabolism and mental health, revealing how the foods we eat profoundly impact not just our bodies but our minds. As a Harvard psychiatrist and director of the Metabolic and Mental Health Program at McLean Hospital, Chris shares compelling evidence that many psychiatric conditions may fundamentally be ...

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