Aging and Longevity

Aging touches everyone, but is it inevitable? In Forever? Aging, Science, and the Search for Longevity, AI host Ezra Wade takes you on a fascinating journey through the cutting-edge science of growing older. From the molecular clocks ticking inside your cells to the centenarian communities that seem to have cracked longevity's code, from promising biotech breakthroughs to the profound ethical questions they raise—this six-part series explores what it really means to age and whether we can change the

Wade investigates the modern biotechnology approach to anti-aging, separating legitimate scientific research from marketing hype. The episode explores promising interventions like senolytic drugs that remove damaged cells, NAD+ boosters, gene therapy approaches, and repurposed medications like metformin and rapamycin. Wade explains the challenges of testing anti-aging interventions in humans and provides guidance for evaluating anti-aging claims critically. While acknowledging the potential of

This episode takes listeners on a global tour of Blue Zones—regions where people routinely live past 100 while maintaining health and vitality. Wade examines five distinct populations: the relaxed Ikarians of Greece, the purposeful shepherds of Sardinia, the community-focused Okinawans, the active Nicoyans of Costa Rica, and the health-conscious Seventh-day Adventists of Loma Linda, California. Despite their cultural differences, these populations share common patterns: integrated physical activity,

The Clock Within Us Ezra Wade introduces the biological mechanisms that drive aging at the cellular level. The episode explores telomeres—the protective caps on chromosomes that shorten with each cell division—and explains how cellular damage accumulates through oxidative stress, DNA damage, and declining repair systems. Wade examines senescent cells, those damaged cells that stop dividing but continue secreting harmful compounds, and explains why aging isn't simply about time passing but about