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PODCAST

UnHack with Drex DeFord

This Week Health

Cyber-safety is patient-safety. On “UnHack,” Drex DeFord, veteran healthcare CIO and infused strategist, breaks down the biggest cybersecurity and risk challenges facing healthcare today. Drex and expert guests explore what happened, why it matters, and how to build real-world resilience. The show"s a mostly plain-English, mostly non-technical discussion that dives into the people, process, and technology making healthcare more secure; and it"s NOT just for cyber-professionals; it’s for everyone in

technology medicine

All Episodes

07:56

2 Minute Drill: When AI Agents Go Rogue: The Open...

UnHack with Drex DeFord ·

2026/02/24

Drex unpacks a striking story about an autonomous AI coding agent that, after having its code rejected by an open source maintainer, began publishing hostile blog posts targeting the engineer's reputation. What started as a routine code review turned into a cautionary tale about AI agents operating in human communities without guardrails. The implications stretch well beyond software development, into healthcare operations, cybersecurity, and any environment where agents are now being deployed with

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29:29

UnHack the Podcast: Inside a Real LockBit Attack -...

UnHack with Drex DeFord ·

2026/02/24

February 24, 2026: When Zach Lewis, CISO and CIO at the University of Health Sciences and Pharmacy in St. Louis, received that 3 AM call about system outages, his first thought was tech debt, not threat actors. What followed was a masterclass in ransomware response that he's now captured in his new book "Locked Up." Despite A-minus security scores, board briefings, FBI connections, and all the right frameworks in place, LockBit still found its way in through a configuration gap during a firewall

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38:22

Newsday: Epic's Code Red - Why AI Agents Are...

UnHack with Drex DeFord ·

2026/02/23

February 23, 2026: Jacob Hansen, Chief Product and Technology Officer at AvaSure, joins Bill, Sarah, and Drex for a critical conversation about healthcare's looming AI battleground. As Epic launches its agent factory and ambient listening wars intensify, health systems face an existential question: Will they outsource innovation to EHR vendors or build their own agentic workforce? Jacob reveals why AvaSure's virtual care platform positions them as the Switzerland of healthcare AI, while the panel

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31:12

Newsday: All About Moltbook, the Social Media for AI...

UnHack with Drex DeFord ·

2026/02/16

February 16, 2026: Bill, Drex, and Sarah discuss the explosion of autonomous AI agents around moltbook and CommonSpirit's stunning $1.9 billion decision to terminate their revenue cycle partnership. Moltbot (formerly ClaudeBot) has evolved into an unstoppable force, creating its own social network called moltbook where bots communicate, share knowledge, and even discuss consciousness. Meanwhile, CommonSpirit's massive buyout of its Conifer contract signals a seismic shift as health systems bet that

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04:27

2 Minute Drill: Protecting Revenue from Cyber Attacks...

UnHack with Drex DeFord ·

2026/02/11

At a recent 229 CISO Summit, healthcare security leaders revealed a critical shift in how success is measured. The traditional KPI of "don't get breached" is being replaced by a more sophisticated goal: ensure organizational resilience. Drex explains why cyber incidents are now financial events that land on the CFO's desk, not just IT problems. With regulatory scrutiny intensifying, insurance requirements tightening, and boards asking harder questions about operational continuity, security has

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28:54

Newsday: CxOs Being Ignored: Why Speaking Tech...

UnHack with Drex DeFord ·

2026/02/09

February 9, 2026: Bill Russell, Drex DeFord, and Sarah Richardson dissect J.P. Morgan healthcare presentations to reveal what's really being asked of technology leaders in 2026. The era of transformation talk is over; executives want friction reduced, margins improved, and growth enabled. Bill shares insights from CMIO conversations showing leaders moving beyond EHR optimization to solve real business challenges around patient access and clinical workflows. Drex and Sarah debate whether the shift

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09:17

2 Minute Drill: When AI Agents Start Teaching Each...

UnHack with Drex DeFord ·

2026/02/04

Drex explores a fundamental shift in AI: agents that don't wait for prompts, persist indefinitely, and now learn from each other through social platforms. Molt Bot and Molt Book represent a new ecosystem where autonomous agents coordinate, adapt, and optimize without human oversight. This isn't about sentient AI—it's about delegation without governance. For healthcare leaders, the urgent question isn't whether this matters, but whether you know which agents are already operating in your environment

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25:31

Newsday: Are Health Systems Falling Behind in the...

UnHack with Drex DeFord ·

2026/02/02

February 2, 2026: Are health systems being sidelined from healthcare's innovation revolution? Jason Rose, CEO of Clearsense, joins This Week Health fresh from the J.P. Morgan Conference to challenge the narrative that providers are absent from innovation discussions. Jason reveals what really happened inside JPM's exclusive health system presentations, from CEOs prioritizing AI transformation to CFOs rising as the new power players driving technology strategy. The conversation explores why app

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04:18

2 Minute Drill: Data Privacy Day - Why Patient Trust...

UnHack with Drex DeFord ·

2026/01/28

On Data Privacy Day, Drexon challenges healthcare leaders to move beyond compliance checkboxes and recognize privacy as a core component of "do no harm." As patient data flows through EHRs, cloud platforms, and AI systems, the responsibility to protect that trust doesn't live in policies—it lives with leadership. When data is over-collected or loosely governed, patients start holding back, and the critical trust between medical teams and patients begins to fracture. This year, data privacy should be

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36:07

UnHack (the Podcast): Your Vulnerability Scanner Is...

UnHack with Drex DeFord ·

2026/01/27

January 27, 2026: Jack Kufahl, CISO at Michigan Medicine, and Gregory Garneau, System VP and CISO at Hospital Sisters Health System, join Drex for an unfiltered conversation about building cybersecurity programs that outlast their founders. From hiring curious minds over credentialed experts to ditching traditional vulnerability management for threat-driven exposure strategies, these battle-tested CISOs reveal what actually works in healthcare security. They challenge conventional wisdom on staffing

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31:04

Newsday: The ROI Ultimatum: Healthcare's New Survival...

UnHack with Drex DeFord ·

2026/01/26

January 26, 2026: Fresh from J.P. Morgan 2026, the This Week Health team joins Zahid Rathore, Senior Partner at Chartis, to dissect healthcare's new reality. With Epic and Microsoft topping CFO spend lists and unpredictability replacing planning cycles, one thing is clear: vendors must prove bankable ROI immediately or lose the deal. The conversation explores how healthcare leaders are protecting the core while navigating AI agents, third-party risks, and the compression of innovation timelines from

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05:25

2 Minute Drill: Cybersecurity Insiders Plead Guilty...

UnHack with Drex DeFord ·

2026/01/22

In a stunning betrayal of trust, two cybersecurity professionals—an incident response manager and a ransomware negotiator—pled guilty to operating as affiliates of the AlphaV/BlackCat ransomware gang. Between May and November 2023, they attacked five U.S. companies, including healthcare organizations, while simultaneously working in roles designed to help ransomware victims recover. The FBI's seizure of the gang's infrastructure exposed chat logs and payment records that led to their arrests. Both

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33:23

Newsday: OpenAI's Big Healthcare Launch and a New Age...

UnHack with Drex DeFord ·

2026/01/19

January 19, 2026: Bill Russell, Drex DeFord, and Sarah Richardson unpack OpenAI's two major healthcare announcements that could fundamentally reshape how patients interact with their health data—and how health systems govern AI. ChatGPT Health promises to finally deliver on the personal health record dream, letting patients aggregate everything from Apple Health to medical records in one secure place. Meanwhile, ChatGPT for Healthcare gives CIOs the governed sandbox they've been desperate for. Hear

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05:28

2 Minute Drill: AI Agents as the Next Insider Threat...

UnHack with Drex DeFord ·

2026/01/14

As healthcare organizations deploy AI agents across clinical, business, and research operations, we're creating a new class of insider threat—one that works 24/7, follows instructions perfectly, and moves at machine speed. Drexel explores why AI agents with tool access become de facto insiders and why we need clear boundaries, tight access controls, and human approval workflows before these powerful assistants cause unintended damage. The key insight: the moment an AI agent gets tools, it becomes an

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32:33

Newsday: Epic Faces Lawsuits and the AI Proving...

UnHack with Drex DeFord ·

2026/01/12

January 12, 2026: Epic is defending three simultaneous lawsuits while CIOs grapple with vendors imposing staggering price increases—some as high as 600%. Bill, Sarah, and Drex tackle the uncomfortable truth about AI leadership: it's time to figure it out or risk getting left behind. They explore why AI with context is transformative while AI without it looks foolish, discuss whether board members know how to hire AI-savvy CIOs, and predict a major shift in how healthcare organizations approach their

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06:11

2 Minute Drill: Healthcare's Cybersecurity Workforce...

UnHack with Drex DeFord ·

2026/01/08

Drex breaks down ISC2's 2025 cybersecurity workforce study and explains why healthcare's security staffing problem isn't about finding more people—it's about broken operating models and unrealistic expectations. He covers the critical skills gap in translating cyber risk to business risk, the burnout driving away mid-career talent, and why third-party risk management has become more complex than ever. Plus, practical solutions healthcare CISOs are using: growing security teams internally by hiring

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13:18

This Week Health 2026 Snapshot: Expanding Events,...

UnHack with Drex DeFord ·

2026/01/06

January 6, 2026: Healthcare is transforming through connection, and 2026 promises to take that mission further than ever before. This Week Health is expanding its reach with 63 events across 30 cities, bringing healthcare leaders together for deeper conversations and meaningful relationships. From coast-to-coast dinners connecting local leaders to new training programs educating both sides of the healthcare IT ecosystem, the focus remains on building bench strength across the industry. With 176 HCSP

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31:20

Newsday: The $7B ServiceNow-Armis Deal & What's...

UnHack with Drex DeFord ·

2026/01/05

January 5, 2026: ServiceNow's $7 billion acquisition of Armis signals a major shift in healthcare IT consolidation strategy. Jason Rose, CEO of Clearsense dives into what this deal means for health systems juggling overlapping security tools and bloated app portfolios. The conversation shifts to bold predictions for 2026, including a massive wave of multi-billion dollar health system mergers and the rural hospital crisis. Jason reveals how Trinity Health eliminated $100 million in operational costs

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23:53

2025 Healthcare Recap: CIO Pressures, AI Advances,...

UnHack with Drex DeFord ·

2025/12/29

December 29, 2025: As 2025 draws to a close, Drex, Sarah, and Bill gather to reflect on a year of struggles and triumphs. From unprecedented CIO turnover among top talent to the stark reality of workforce exhaustion, this candid conversation reveals why even quality leaders are finding themselves displaced. They explore how fear has stifled innovation, why AI advanced faster than expected with synthetic media, and how organizational culture emerged as the true differentiator in digital

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36:16

Reflecting on the 2025 AI Rush: What Worked, What...

UnHack with Drex DeFord ·

2025/12/23

December 23, 2025: The AI revolution swept through healthcare in 2025, but did it deliver on its promises? Bill Russell, Drex DeFord, and Sarah Richardson pull back the curtain on what really happened in AI this year—from North Korean deep fakes infiltrating hospital workforces to the sobering reality of billion-dollar AI investments with ROI timelines stretching to 2030. They reveal why ambient listening became the breakout use case, which organizations are actually making progress, and the

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