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PODCAST

Frameshifts with Benjamin Arya

Spotlighting the world’s most ambitious biotech founders, investors, researchers and change-makers. frameshifts.bio

science life sciences

All Episodes

77:03

Why 92% of Your Proteins Are Invisible — Parag...

Frameshifts with Benjamin Arya ·

2025/12/17

Parag Mallick is a Stanford Professor and Chief Scientist at Nautilus Biotechnology, a publicly traded biotech company. He’s also a professional magician and circus performer, which might sound random until you realize that his company does the closest thing to proteomics magic I’ve ever seen. The things that make you weird, he argues, are exactly what let you see data differently than anyone else.Here’s what caught me off guard: we can only measure ~8% of human proteins with current mass

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76:32

Building the Wyss Institute, Organs-on-Chips, and...

Frameshifts with Benjamin Arya ·

2025/12/02

The future of human biology isn’t about better animal models - it’s about building human organs on chips that think like the body does.Don Ingber, founding director of Harvard’s Wyss Institute, has one of the most unconventional origin stories in the field. In 1975, as a Yale undergrad, he took a sculpture class where students built floating structures held together only by tension; no rods touching, no rigid frames. At the same time, he watched cells in culture flatten, round up, and then flatten

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66:06

Shelby Newsad: Why Platforms Fail, What Founders...

Frameshifts with Benjamin Arya ·

2025/11/25

This week, I sat down with Shelby Newsad, Partner at Compound VC, to break down what makes a great biotech investment and why so many platform stories fall short.Shelby lays out a playbook forged across therapeutics, diagnostics, and lab automation. We dive into why mechanistic understanding predicts success, how diagnostics evolve into data businesses, and why the next wave of value may come from closed loop automated labs that combine hardware and software to finally link the whole bench.We

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71:16

Space Travel, AI, and Immortality — Peter Diamandis |...

Frameshifts with Benjamin Arya ·

2025/11/18

What happens when the man who launched commercial spaceflight decides humanity needs to stop aging?Peter Diamandis is building the infrastructure to tackle aging. He founded the XPRIZE Foundation, created Singularity University with Larry Page and Ray Kurzweil, and wrote the playbook on exponential thinking with Abundance and Bold. However, somewhere between flying Stephen Hawking into zero gravity and recruiting Elon Musk to his board, he realized something: if we’re building an unlimited future,

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85:49

Minimally Invasive Neurosurgery, Brain-Computer...

Frameshifts with Benjamin Arya ·

2025/11/11

What happens when one of the world’s leading neurosurgeons steps away from the operating room to become a first-time founder? Dr. Theodore Schwartz pioneered minimally invasive brain surgery going through the nose and eyelid instead of opening the skull. He’s published over 200 papers, written a bestselling book on neurosurgery history, and now he’s building a MedTech startup to solve a problem that’s plagued him for decades: there’s no way to continuously monitor a patient’s pupils during

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81:48

Michael Florea: Smart Cages, AAV Cocktails & The...

Frameshifts with Benjamin Arya ·

2025/11/04

This week, I sat down with genome engineering prodigy Michael Florea.I first met Michael at the Longevity Biotech Fellowship retreat in Tahoe National Forest, California (2.5hrs east of SF). I was in the final days of building an AI edtech startup, and looking for advice on what to do next.Michael had been genetically engineering longevity since he was 16 years old. What he always wanted to do was extend the human lifespan. But he decided that the most impactful technology he could work on first was

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84:41

Virtual Cells, Programmable Biology, and the Quest to...

Frameshifts with Benjamin Arya ·

2025/10/09

This week, I sat down with Omar Abudayyeh and Jonathan Gootenberg, the co-PIs who helped pioneer the field of genome engineering, and are now leading one of the most innovative and productive bioengineering labs in the world.Omar and Jonathan met as graduate students in the lab of CRISPR pioneer, Feng Zhang. They have since co-authored more than 30 breakthrough papers that helped transform CRISPR-Cas from a basic research tool into a clinically relevant therapeutic and diagnostic modality. Their

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81:04

Francisco LePort & Martin Borch Jensen: The Biotech...

Frameshifts with Benjamin Arya ·

2025/10/01

In this week’s episode, I sit down with Francisco LePort and Martin Borch Jensen, the co-founders of Gordian Biotechnology. Gordian is revolutionizing drug discovery by testing where it matters most… directly in living organisms. We discuss their groundbreaking approach of pooled in vivo screening that transforms a single organism into thousands of parallel experiments, and how this could fundamentally change our approach to studying age-related diseases.Francisco and Martin believe that traditional

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78:15

Ron Weiss: Building Biological Neural Networks to...

Frameshifts with Benjamin Arya ·

2025/09/24

In this week's episode, I sit down with Prof. Ron Weiss, the MIT pioneer who helped create the field of synthetic biology. We discussed the emergence of living therapeutics that can think, adapt, and make complex decisions inside the human body. The implications of this stretch from synthetic cells within implantable biosensors that can produce insulin based on real-time glucose sensing to self-amplifying RNAs encoding gene circuits that specifically detect and kill cancer cells.Ron believes the

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81:57

Kevin Esvelt: Sculpting Evolution, Engineered Viruses...

Frameshifts with Benjamin Arya ·

2025/09/11

“What I wanted to do was harness evolution as effectively as possible.”In this episode, I sit down with pioneering synthetic biologist Kevin Esvelt. Together, we explore how technologies like gene drives and phage-assisted continuous evolution could help tackle humanity’s toughest challenges, from eradicating malaria to protecting global food security. We also dig into the urgent need to safeguard biotechnology against misuse.This is a conversation about the future of science, biosecurity, and

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10 results

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