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PODCAST

SKRAPS: Deep Dive

SKRAPS is your podcast where we, on your behalf explore the stories of sparks of scientific brilliance in science and innovation. SKRAPS is the word sparks spelt backwards and also a play on the idea that ideas are written on back of a napkin or scraps of paper. We explore stories of people in science, while elaborating on the scientific details so that experts and non-experts can relate to science better in today"s whimsical world that acts to spread mis-information.

science life sciences

All Episodes

17:40

And then came the microelectrode...!

SKRAPS: Deep Dive ·

2025/03/12

How do we even know what constitutes the heart beat? What was the reason for all those abnormal rhythms of the heart? Why does it happen? The answer lies in the small, cylindrical glass tube called the micropipetter, which was used to create a microelectrode. Here it is, on how the microelectrode changed the face of cardiology. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and

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22:58

Sudor Anglicus: The English Sweating Sickness

SKRAPS: Deep Dive ·

2025/02/24

What connects Tudor England, Ann Boleyn, Henry the VIII, autonomic nervous system and a flash mob like wave of a deadly disease? There is only way to find out. Inspired by this paper and Dr. Ali Christy's X thread. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Created & Produced by: Arun Sridhar You can help us fund the production costs by donating as a one time or a

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14:10

R.I.P ... CDC's Epidemic Intelligence Service

SKRAPS: Deep Dive ·

2025/02/15

This story was inspired by the post on X by Dr. Farsad Mostashari. Center for Disease Control has been at the forefront of many of the alerts (true and false) and now it's officially gone...This is a sombre take on what has happened. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation. Show CreditsCreated & Produced by: Arun Sridhar & JoJo PlattEditing: Arun SridharSound

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41:36

Sympathetically, Un-sympathetic

SKRAPS: Deep Dive ·

2023/03/31

This is conclusion of the mini-series! In this episode, we uncover the question, is the "cholinergic anti-inflammatory reflex" nerves entirely vagal? The answer is not so straightforward. Building on good work by Davide Martelli and Robin McAllen, we uncover crucial role of the efferent arm of the reflex to "also" be sympathetic.And at the end, we also talk about the importance of understanding the referral and implantation pathway and why we remain muted in the ability of neuromodulation for

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46:06

The Inflammation

SKRAPS: Deep Dive ·

2023/02/14

With the set up of how vagus signalling was deduced by careful and meticulous experiments of Linda Watkins, who built on some amazing results from Hugo Besedovsky, we turn our attention to how the hypothesis moved from tackling acute inflammatory models (e.g. Sepsis) to chronic inflammatory models and disease conditions like Rheumatoid Arthritis. We are joined by Tony Arnold, ex-CEO of SetPoint Medical and Dr. Paul-Peter Tak who pioneered the clinical trials in Rheumatoid Arthritis and Inflammatory

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53:16

Las Vagus, Baby!!

SKRAPS: Deep Dive ·

2023/01/31

What happens in the vagus, stays in vagus?? Not with us at SKRAPS. “Science Is a Team Sport”If we truly mean this - I mean, really and truly mean that science is a group effort and not the effort of one person, let’s really dive in to this and embrace our opportunities to set the record straight. And I mean let’s startright now!As we endeavor to understand The Wanderer, we must also strive to understand the contributors - and not just the marquee names. We hope to shed light on the nerve, the

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03:09

Trailer - The Inflammatory Wanderer

SKRAPS: Deep Dive ·

2023/01/24

Can you tell me the last time that you know of that we eulogised and attributed even the most difficult concepts to a single eureka moment?Was it yesterday?Was it last week?Was it last month?We have this image of a human jumping out of a bathtub and running naked, shedding your rica or an apple falling from a tree or in the case of psychedelic medicine, the famous bicycle trip of Albert Hoffman.If you think you love this romanticised version, let me break this idea for

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01:30:46

History of Serotonin - Lessons in how science and...

SKRAPS: Deep Dive ·

2022/11/08

JoJo and Arun are producing some key content that will make you turn your heads in disbelief. Until then, we thought it would be good to get your mind focussed on that wonderful molecule - serotonin that has received fresh life due to its impact on mental health, be it with psychedelics or with electrical stimulation for depression etc. This episode details some wonderful history of how our body is complicated and yet so wonderful and how there are lessons for everyone irrespective of whether you

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01:22:08

BCI's On The Grill 🥩 - Candid Questions in...

SKRAPS: Deep Dive ·

2022/10/31

WhatIsa BCI? And just as importantly, whatisn’ta BCI?This is an unusual episode and an incredibly fun one. Arun and JoJo enlisted some of the field’s top folks to talk through what’s in and what’s out in this exciting field.Amy Kruseis a general partner at Prime Movers Lab and a self-professed Founder turned Funder (and a neuroscientist by training),Matt Angleis the founder and CEO of Paradromics - developing high data rate BCIs, andMarcus Gerhardtis the co-founder and CEO of Blackrock Neurotech and

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44:13

Why did Merck KGaA venture into Bioelectronics? -...

SKRAPS: Deep Dive ·

2022/10/21

At SKRAPS, we are always looking to get behind the veil of the happenings in the field. We want to go beyond the facade of the news headlines.In recognition of this, we are now reading the slug for part 1 of candid conversations or plainly put - “Cutting through the crap in Bioelectronics”. So, we are joining Dr. Robert Spoelgen, Head of Bioelectronics at Merck KGaA, Darmstadt, 🇩🇪 (They are very particular about this as Merck and Merck KGaA are two separate entities) about their entry, reason,

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01:10:37

It's time for DANC - “Dynamic ANC (Active "Nerve”...

SKRAPS: Deep Dive ·

2022/10/03

Julia Child was a master. She was not a classically trained chef, but pursued cooking as a hobby. Her super power? Passion. A passion for making gastronomy accessible, to deliver an honest and attainable presentation, and she possessed a pure, unadulterated joy for her craft. While Michael Ackermann isn’t a neurotechnolgy hobbyist, he does share other qualities with the inimitable Child. He brings a passion for neurotechnology, mixes it with technical expertise picked up at Case Western Reserve

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01:33:20

It's the Second Anniversary of Skraps Podcast

SKRAPS: Deep Dive ·

2022/09/06

Skraps is turning two. Or is it our second anniversary? I can't quite decide so let's celebrate both. Join us as we walk down memory lane with some highlights (and hopefully no lowlights) of the past two years of their audio partnership. Re-live some of our favorite moments - laughter, tears, learning, and even occasionally, listening. We revisit early episodes (and see how far we've come) with Kit Parker, Stanton Rowe, Sandy Greenberg, and more. With so many hours under our belts, it is impossible

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31:40

Our British Podcast Awards Nomination Tape

SKRAPS: Deep Dive ·

2022/06/22

Hello friends and dear listeners,Recently, we were urged by a couple of our British listeners and experienced audio producers in the podcasting space, to nominate our last season’s science documentary podcast on Psychedelics for the British Podcast awards.Without further adieu, here is the 30 minute tape we sent for the second stage of the nomination.SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science,

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47:30

European Innovation Council & NeuroTechnology/MedTech...

SKRAPS: Deep Dive ·

2022/06/15

Funding for Bioelectronic Medicines does not come from traditional venture capital. It also comes from grant funding agencies. While the most well known grant funding bodies are NIH and DARPA in this area, there is also a renewed deeper interest in funding early research to develop products for clinical applications from the EU as well.So we invited, Dr. Enrique Claverol-Tinture (Enric), Program Manager of the Medical Technologies Program to talk about their most recent EIC pathfinder and

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01:17:56

Sleep Apnea: ft. Napoleon, Churchill, Brahms, Stalin...

SKRAPS: Deep Dive ·

2022/05/29

“Laugh and the world laughs with you. Snore and you sleep alone” is a famous quote from the author Anthony Burgess.Sleep Apnea affects 425 million adults over the age of 40. Yet, good treatments are unavailable. In this episode we address how Bioelectronic Medicines helps to alleviate the problem.Links as promised:Inspire Medical - the first hypoglossal nerve stimulation product on the market. Kingman Strohl’s lecture A Ted Talk on Didgeridoo SKRAPS is your podcast, where we on your behalf explores

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01:18:54

S4 E7: Investing (exclusively!!) in Bioelectronic...

SKRAPS: Deep Dive ·

2022/05/04

We are joined by Imran Eba of GlaxoSmithKline's Bioelectronic Medicine fund - Action Potential Venture Capital to talk about investing in Bioelectronic Medicines. APV is the only fund that invests exclusively in bioelectronic medicines - and they've been here since the beginning. This leads to the ongoing question: what is and what is not a bioelectronic medicine (hear all three answers.) After we get through the personal grooming habits of the hosts and our guest as well as the obligatory cricket

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01:00:48

S4 E6: Research Pioneers ft. Ian Burkhart & Benjamin...

SKRAPS: Deep Dive ·

2022/04/20

Most of us can pretty certainly say that we are alone within our heads. We may joke about inner voices, but what really happens when there genuinely is an external influence deep within a brain? The answer? In the case of two research pioneers, Ian Burkhart and Benjamin Stecher, the answer is nothing short of a miracle. These two souls both underwent life altering surgeries - not just in terms of literally allowing a device to tap into their brains, but surgeries that would do for them what no pill,

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58:43

S4 E5: The Killing

SKRAPS: Deep Dive ·

2022/03/18

PUT YOUR HEADPHONES ON! What does a 4 cm long and 25g in weight crustacean have to teach us about Bioelectronic Medicine and human health? And what does its feeding habits have to tell us about how we deal with tumours? Well, there is more than what meets the eye! If we reveal more than this, we are breaking the plot to you and making your life easy. So, it is time to do the hard yards and go on this underwater exploration first, before we figure out a new frontier for Ultrasound modulation of nerve

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01:13:07

S4 E4: The Ultrasounds of Silence

SKRAPS: Deep Dive ·

2022/03/06

The saying, as grotesque as it might be, goes "there's more than one way to skin a cat." In our case, there's more than one way to stimulate a nerve and we've gathered some experts leading the charge (pun very much intended.) Gather around the fire, bring some marshmallows and listen in as we chat with Hubert Lim of the University of Minnesota, Christopher Puleo of GE Research, and Mikhail Shapiro of CalTech about the power and the fury of ultrasound.There are two things that are guaranteed with

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56:25

S4 E3: Basic Bench - Bedside Considerations For...

SKRAPS: Deep Dive ·

2022/02/18

Have you ever wondered what decisions go behind deciding if a pharmaceutical is to be administered either orally or intravenously or via inhalation. Who decides that? Well, the short answer is that it is decided based on a tested pharmaceutical developmental framework that has stood the test of time. First, it is determined by a clinical need, then by what the drug does to the body (pharmacodynamics) and what the body does to the drug (pharmacokinetics) married with other commercial question. Now,

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