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PODCAST

Pathocast in Review

The Pathocast in Review adopts a journal club format to critically dissect the latest research in immunology, virology, and infectious disease. Join our panellist as they deep-dive into recently published studies in a roundtable discussion. Leaving no stone unturned—we cover groundbreaking work across basic science, translational research, and clinical studies that are pushing the boundaries of the field. follow us on: Instagram - instagram.com/pathocast_review Tiktok -

science life sciences

All Episodes

00:47:31

From Immune Beginnings to Broader Protection

Pathocast in Review ·

2026/10/04

Welcome to Pathocast In Review – S2. Ep5What if the first week of life is not simply a period of immuneimmaturity, but a highly regulated state of immune adaptation? In this episode,we explore transcriptomic changes in newborns from two African populations,revealing that age shapes early-life immune responses more strongly thanpopulation, with a striking surge in neutrophils alongside tight regulation ofinflammation. Are we telling the story of early-life immunity correctly?We then turn to mRNA

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01:03:30

From Dieting to Treat Cancer to Fine-Tuning Child...

Pathocast in Review ·

2026/09/06

Welcome to Pathocast In Review – S2. Ep4What do diet, the gut microbiome, and multi-omicshave in common? In this episode we explore how the gutmicrobiome, microbial metabolites and Th17 cells may connect ketogenic diets with colorectal cancer protection. We then dive into multi-omic data from infants across Africa and Southeast Asia, where malnutrition emerged as thestrongest predictor of post-discharge mortality, withproteomic biomarkers outperforming metabolic and metagenomic approaches.Papers in

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01:00:14

From Fasting Immune Cells to the Gut–Neurodiversity

Pathocast in Review ·

2026/08/16

Welcome to Pathocast In Review – S2. Ep3 – Can we really improve vaccine responses by giving someone a meal first, or is there a deeper connection between fasting, diet, and immunity? And could ADHD and autism have roots in the gut?In this episode, we explore how fasting and dietary lipids can change the fitness and function of the immune system, and how interactions between the microbiome and the epigenome in early life may influence a baby’s neurodevelopmental trajectory. Papers in Review:1

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00:46:41

From Engineered Breast Milk to Crossing Africa's...

Pathocast in Review ·

2026/08/02

Welcome to Pathocast In Review – S2. Ep2 – What if we could give formula-fed babies some of the same microbiome advantages as breastfeeding? And why does the microbiome look so different across Africa while remaining unique to the rest of the world? Join us as we unpack the science behind infant gut development, explore an innovative antibody-based approach to directing microbiome development in formula-fed infants, and travel across the continent to discover how environment, culture and lifestyle

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00:52:50

From Universal Vaccines to Smarter HIV Vaccines

Pathocast in Review ·

2026/06/21

Welcome to Pathocast In Review – S2. Ep1 – The wait is over. In this episode, we explore cutting-edge advances in vaccinology and immunology, from the pursuit of a universal vaccine to innovative strategies aimed at enhancing HIV vaccine efficacy. We discuss the exciting possibility of a single mucosal vaccine capable of providing protection against a broad range of pathogens and examine the scientific challenges involved in achieving this goal.We also shift gears to the role of immune checkpoint

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00:53:32

When Biology Meets Inequality

Pathocast in Review ·

2025/12/21

Welcome to Pathocast In Review – S1. Ep7 – What if winter doesn’t just change the weather but also your microbiome? In this seventh and final episode, we explore how seasonal shifts shape gut microbial diversity, and why fermented foods consumed during colder months may reduce diversity in a beneficial and stabilising way. We then switch our focus to spotlight issues in public health, unpacking how socioeconomic conditions, such as maternal education, income level and wealth which are defined

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00:49:25

Womb Echoes: Why Second Pregnancies Flourish and How...

Pathocast in Review ·

2025/11/28

Welcome to Pathocast In Review – S1. Ep6 – The sixth instalment explore how maternal biology shapes the health and development of the next generation. We unpack the maternal immune mechanisms that support a successful pregnancy, focusing on the pivotal role of regulatory T cells (Tregs) in preventing miscarriage and ensuring tolerance in subsequent pregnancies. We then shift to the maternal microbiome, examining emerging evidence on how a mother’s microbial community can influence the neurological

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00:46:59

Beyond the Years: How HIV and Obesity Rewire Ageing

Pathocast in Review ·

2025/10/26

Welcome to Pathocast In Review – S1. Ep5 - On this fifth instalment we explore new evidence showing how HIV infection accelerates biological ageing, not just in years lived, but deep in the molecular architecture of antibodies revealing that changes in antibody glycosylation can predict ageing long before clinical signs appear, offering a molecular window into how chronic inflammation reshapes immune function. We then turn to obesity, a condition now understood to reprogram adipose tissue in lasting

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00:55:33

From Ageing Immunity to Infant Gut Resistome

Pathocast in Review ·

2025/09/28

Welcome to Pathocast In Review – S1. Ep4 - From AgeingImmunity to Infant Gut Resistome. On this fourth instalment, we unpack how ageing reshapes the immune landscape, where multi-omic profiling using single cell RNA-sequencing and mass cytometry reveals that CD8 T cells bear the brunt of age-related changes, while children show a surprising enrichment of cytotoxic B cells. Then, we turn to a longitudinal mother-infant analysis exploring factors that contribute to the development of infant gut

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00:53:12

Immune Harmony and Disruption: IgA in the Gut, and...

Pathocast in Review ·

2025/08/17

Welcome to Pathocast In Review – S1. Ep3 - Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS. The third episode explores how secretory IgA shapes intestinal immune balance by limiting viral colonisation, and how its absence triggers a compensatory expansion of CD8 T cells. We also examine how gestational diabetes disrupts maternal immunity and alters the vaginal microbiota, amplifying the harmful effects of Group B Streptococcus colonisation during pregnancy.Papers in

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00:48:59

Silent Shifts: How Early Life Antibiotics and Hidden...

Pathocast in Review ·

2025/07/13

Welcome to Pathocast In Review – S1. Ep2 - Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity. In this second episode, we explore the far-reaching consequences of early-life antibiotic use. Beyond driving the emergence of antibiotic resistance, these interventions disrupt the developing microbiota—blunting vaccine responses and leaving infants more vulnerable to infections. We also dive into cutting-edge research using a mouse model system to track latently HIV-infected

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00:56:14

Targeting precursor B Cells for bnAbs | Antibiotics...

Pathocast in Review ·

2025/06/08

Welcome to Pathocast In Review – S1. Ep1: Targeting precursor B Cells for bnAbs | Antibiotics to protect uncircumsed from HIV.In our premiere episode, we dive into the cutting edge of HIV science. Join us as we explore the latest findings on the quest for an effective HIV vaccine—specifically, how broadly neutralising antibodies are induced by vaccines by targeting extremely rare precursor B cells.We also unpack new research into how antibiotics might offer an unexpected tool in HIV prevention for

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