Pathocast in Review

Welcome to Pathocast In Review – S1. Ep5 - On this fifth instalment we explore new evidence showing how HIV infection accelerates biological ageing, not just in years lived, but deep in the molecular architecture of antibodies revealing that changes in antibody glycosylation can predict ageing long before clinical signs appear, offering a molecular window into how chronic inflammation reshapes immune function. We then turn to obesity, a condition now understood to reprogram adipose tissue in lasting

Welcome to Pathocast In Review – S1. Ep4 - From AgeingImmunity to Infant Gut Resistome. On this fourth instalment, we unpack how ageing reshapes the immune landscape, where multi-omic profiling using single cell RNA-sequencing and mass cytometry reveals that CD8 T cells bear the brunt of age-related changes, while children show a surprising enrichment of cytotoxic B cells. Then, we turn to a longitudinal mother-infant analysis exploring factors that contribute to the development of infant gut

Welcome to Pathocast In Review – S1. Ep3 - Immune Harmony and Disruption: IgA in the Gut, and Gestational Diabetes Risks GBS. The third episode explores how secretory IgA shapes intestinal immune balance by limiting viral colonisation, and how its absence triggers a compensatory expansion of CD8 T cells. We also examine how gestational diabetes disrupts maternal immunity and alters the vaginal microbiota, amplifying the harmful effects of Group B Streptococcus colonisation during pregnancy.Papers in

Welcome to Pathocast In Review – S1. Ep2 - Silent Shifts: How Early Life Antibiotics and Hidden HIV Cells Shape Immunity. In this second episode, we explore the far-reaching consequences of early-life antibiotic use. Beyond driving the emergence of antibiotic resistance, these interventions disrupt the developing microbiota—blunting vaccine responses and leaving infants more vulnerable to infections. We also dive into cutting-edge research using a mouse model system to track latently HIV-infected

Welcome to Pathocast In Review – S1. Ep1: Targeting precursor B Cells for bnAbs | Antibiotics to protect uncircumsed from HIV.In our premiere episode, we dive into the cutting edge of HIV science. Join us as we explore the latest findings on the quest for an effective HIV vaccine—specifically, how broadly neutralising antibodies are induced by vaccines by targeting extremely rare precursor B cells.We also unpack new research into how antibiotics might offer an unexpected tool in HIV prevention for