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PODCAST

The Synthesis of Wellness®

Chloe Porter is dedicated to health research and optimization. She is the host of The Synthesis of Wellness ® Podcast; an engineer; and an acclaimed health science speaker, expert, and best-selling author known for her deep dives into gastrointestinal function, functional health, and health optimization.

health & fitness alternative health

All Episodes

00:12:38

207. The Intestinal Mucosal Barrier | Intestinal...

The Synthesis of Wellness® ·

2026/03/13

In this encore episode, we detail the structure of the intestinal mucosal barrier alongside central roles that zinc plays in supporting various aspects of mucosal barrier integrity. We discuss key anatomical features, including the mucus layer, epithelial cells, and tight junctions, as well as detail zinc’s physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details zinc levels, zinc absorption, and specialized forms of zinc, such as

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00:14:08

206. The Stomach | Low Stomach Acid, Digestion, & A...

The Synthesis of Wellness® ·

2026/03/06

In this encore episode, we detail low stomach acid while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of suboptimal stomach acid, including impaired digestive signaling, bacterial overgrowth in the small intestine, and more. Topics: 1. Introduction- Highlighting the stomach and stomach acid, as well as microbial balance, dysbiosis, and overgrowth. 2

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00:40:01

205. Red Light Therapy Clinical Studies with Andre...

The Synthesis of Wellness® ·

2026/03/04

In this episode, we are joined by Andre Martin, Founder of Luxxe Red Light™.Topics:1. Example Red Light Therapy Session Parameters - Wavelength- Irradiance at the skin- Session duration2. Clinical Research: Light Penetration and Absorption 3. Irradiance and Distance Relationship4. Clinical Studies - Exercise recovery- Skin Health5. Luxxe Red Light™ Therapy Panels: - Mode-1 and Mode-2 - PRO Mode Customization- Smart Distance Dosing™ - Luxxe Red Light™ Measurement MethodsShop Luxxe Red Light™ here and

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00:14:29

204. Intestinal Barrier Function, The Gut-Immune...

The Synthesis of Wellness® ·

2026/01/30

In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin

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00:13:06

203. The Stomach | Gastric Acid Secretion and the...

The Synthesis of Wellness® ·

2026/01/23

In this encore episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. Topics:1. Hypochlorhydria - Low stomach acid.2. H. pylori 3

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00:12:45

202. Intestinal Hyperpermeability & the Mucosal...

The Synthesis of Wellness® ·

2025/12/05

In this encore episode, we highlight key roles that zinc plays in supporting various aspects of mucosal barrier integrity, while detailing the structure of the intestinal mucosal barrier. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc’s physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized

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00:40:00

201. Supporting Antioxidant Defenses | Phenolic...

The Synthesis of Wellness® ·

2025/11/26

In this episode, we are joined by Dr. Peter Matos who is trained in occupational and preventative medicine and the CEO of O-Liv.Topics: 1. Overview of Phenolic Compounds2. Polyphenols as Antioxidants- Free radicals.- Endogenous vs exogenous antioxidants.3. Olive Phenolic Compounds - Key EVOO phenolics: oleocanthal, hydroxytyrosol, oleuropein.- How phenolic levels differ in the olive fruit, leaf, and oil.- Impact of cultivation, storage, and harvest timing on phenolic levels.- Bioavailability

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00:14:10

200. Intestinal Mycobiome | Small Intestinal Fungal...

The Synthesis of Wellness® ·

2025/11/21

In this encore episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, impaired motility, diminished commensal bacterial populations, and weakened mucosal

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00:51:49

199. The Skin Barrier, Skin Health, and Skin...

The Synthesis of Wellness® ·

2025/10/29

In this episode, we are joined by Olga Goldberger, founder of IOKA Skin + Science. Olga holds a Master’s degree in Molecular Biology, and she strived to create a skincare system that applied science to active botanical ingredients that would penetrate the skin and support skin health on the cellular level.Topics: 1. Anatomy and Function of the Skin Barrier- Structure of the epidermis, highlighting the Stratum Corneum.- Role of corneocytes and intercellular lipids in barrier integrity. 2. Emulsifiers

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00:14:59

198. Small Intestinal Bacterial Overgrowth &...

The Synthesis of Wellness® ·

2025/09/19

In this encore episode, we detail hypochlorhydria while reviewing gastric lining anatomy, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential downstream effects of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on possible influences of the oral microbiome and oral dysbiosis.Topics:

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00:15:48

197. Hydrogen Sulfide-Dominant SIBO |...

The Synthesis of Wellness® ·

2025/09/12

In this encore episode, we detail hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on intestinal motility. We briefly review anatomy, focusing on and detailing the interplay between structures supporting motility. Lastly, we detail possible symptoms of hydrogen sulfide-dominant SIBO as well as possible overlap between or among subtypes.Topics:1. Introduction to Hydrogen Sulfide-Dominant SIBO - Overview of hydrogen sulfide (H₂S) SIBO - H₂S production -

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00:15:22

196. The Stomach, Gastric Acid, & Vitamin B12 | With...

The Synthesis of Wellness® ·

2025/09/05

In this encore episode, we highlight the stomach's role in vitamin B12 absorption and bioavailability, detailing the cellular composition of the gastric mucosa and further highlighting mucous cells, parietal cells, and chief cells. We also briefly discuss Helicobacter pylori and common symptoms, while detailing H. pylori's potential impacts on the gastric mucosal barrier. Topics:1. Introduction- Overview of the stomach's role in B12 absorption- Helicobacter pylori 2. H. pylori Overview-

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00:44:54

195. Histamine Intolerance and Diamine Oxidase...

The Synthesis of Wellness® ·

2025/09/03

In this episode, we are joined by Helmut Schmutz. Helmut developed the original, patented diamine oxidase formulation, and his work serves as a driving force in the innovation at OmneDiem. Topics: 1. Histamine- Exogenous versus endogenous histamine.- Mast cells as a source of endogenous histamine.- Endogenous histamine signaling needed for diverse physiological functions.- Intestinal microbes as a source of histamine production.- Food as a source of histamine.2. Dietary Histamine- Foods higher in

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00:18:29

194. The Oral-Gut Axis | The Oral Microbiome and The...

The Synthesis of Wellness® ·

2025/08/22

In this encore episode, we detail the oral-gut microbiota axis, detailing the oral microbiome and its relationship with the intestinal microbiome. We discuss the development of oral biofilm, the transition from plaque to dental calculus, and potential impacts of oral dysbiosis, while highlighting intestinal health and focusing on Fusobacterium nucleatum. Topics:1. Overview of the Oral Microbiome and the Oral-Gut Axis - The oral cavity and the gut: microbially dense sites. - Anatomically distinct but

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00:15:06

193. The Intestinal Mucosal Barrier &...

The Synthesis of Wellness® ·

2025/08/15

In this episode, we detail the structure and function of the intestinal mucosal barrier, highlighting key roles that zinc plays in supporting various aspects of mucosal barrier integrity. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc’s physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized

en

00:51:59

192. Integrative Dermatology, Eczema, Acne, & The...

The Synthesis of Wellness® ·

2025/08/13

We are honored to be joined today by Dr. Barbara Paldus. Dr. Barbara Paldus is a scientist, serial entrepreneur, and the founder of Codex labs. She holds over 50 US patents and has started multiple companies in various industries, including climate monitoring and biotechnology. She hasdeveloped Codex Labs in order to deliver affordable, clinically proven skin-gut-brain solutions that support the gut microbiome and healthy skin, without sacrificing sustainability. Topics: 1. Eczema- Characteristic

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00:14:24

191. The Gut-Immune Axis | Intestinal Secretory IgA,...

The Synthesis of Wellness® ·

2025/08/08

In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the roles of secretory immunoglobulin A and lactoferrin in intestinal health. We discuss endogenous secretions as well as highlight lactoferrin testing and levels. Topics: 1. The Intestinal Barrier & Mucus Layer- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).- Intestinal epithelial cells

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00:15:00

190. IMO, SIBO Subtypes | Interactions Among...

The Synthesis of Wellness® ·

2025/08/01

In this encore episode, we detail overlap among intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms,

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00:17:57

189. Gastrointestinal Motility | The Role of Vitamin...

The Synthesis of Wellness® ·

2025/07/25

In this encore episode, we highlight the role of vitamin B1 (thiamine) in supporting gastrointestinal function, focusing on intestinal motility while detailing vitamin B1's involvement in acetyl-CoA and acetylcholine synthesis. We discuss thiamine insufficiency as well as how small intestinal bacterial overgrowth (SIBO) may further affect thiamine availability. We further detail host defense mechanisms—including gastric acid, pancreatic enzymes, and gastrointestinal motility—that work in concert

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00:14:47

188. The Stomach | Symptoms of H. pylori &...

The Synthesis of Wellness® ·

2025/07/18

In this episode, we detail connections between H. pylori and hypochlorhydria, while highlighting possible downstream effects on nutrient absorption. We examine how reduced gastric acidity can impair the liberation and assimilation of certain micronutrients, including iron, calcium, vitamin B12, and more; and we further discuss the impact of low stomach acid upon downstream digestive enzyme activation and gut microbial balance. The discussion also highlights the role of compromised gastric acidity in

en

207 results

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