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PODCAST

Daily Value

Dr. William Wallace

Daily Value brings science out of the lab and into daily life. Hosted by Dr. William Wallace, each short, research-driven episode explores how nutrients, supplements, and metabolism influence how we think, move, and age. It’s evidence-based, concise, and designed to make you smarter about what fuels you.

health & fitness alternative health

All Episodes

7:50

The Mitochondrial “Vitamin” from Interstellar Dust

Daily Value ·

2025/11/06

There’s a molecule that’s been tentatively identified in the same interstellar material that forms stars and planets, yet it also shapes growth, metabolism, and cognition here on Earth. In several mammalian species,Its absence causes deficiency and it's repletion, resolution; and no, it’s not a vitamin, but should it be? Its chemistry is analogous to the combination of vitamin B2, vitamin B6 vitamin C, and its role in evolution may trace back to the very beginning of biology. 00:00 – From Int...

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11:25

Boost Your Serotonin Naturally: The Nutrition Secret

Daily Value ·

2025/11/04

Serotonin is often described as the “happiness molecule,” but its biology tells a larger story. Nearly every step in serotonin’s synthesis and signaling, from the transport of dietary tryptophan to the enzymes that convert it, is influenced by nutrition. This episode examines how macronutrients, micronutrients, and gut-derived metabolites shape serotonin availability across the brain and body. Protein and carbohydrate balance determine how much tryptophan enters the brain. Specific vitamins a...

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7:42

Discovered: an amino acid that helps the gut heal itself

Daily Value ·

2025/10/30

Every few days, your gut rebuilds itself completely - cell by cell, guided by signals we still don’t fully understand. For years, scientists have known that diet can influence this process, but the exact messenger between what we eat and how the gut heals has remained a mystery. In this episode, we look at new research from MIT that uncovers a surprising link between diet, the immune system, and regeneration in the intestine. It’s a story about how a single nutrient can activate immune cells ...

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7:34

Creatine’s Role in Mitochondria is Bigger Than You...

Daily Value ·

2025/10/28

Creatine’s story has been far too small for its biology. Most people still see it as a supplement for strength or cognitive performance, but its most important work happens inside the mitochondria. In this episode, we explore a side of creatine few people talk about: how it may function as mitochondrial medicine. We’ll break down 3 distinct ways creatine acts in and supports the mitochondria; roles that could reshape how we think about energy, resilience, and cellular health. And beyond...

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11:20

Polyphenols Are Doing Something No One Expected

Daily Value ·

2025/10/23

In this episode of The Daily Value, we look at new research suggesting that polyphenols might be doing something we never expected — not just acting as antioxidants, but organizing themselves into microscopic structures that can stabilize the very proteins that keep our cells alive. It’s a discovery that could reshape how we think about plant compounds and resilience at the molecular level. We explore how this structural behavior gives new meaning to the idea that diversity matters in our die...

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17:03

Lead Exposure from Protein Supplements Explained

Daily Value ·

2025/10/21

In this episode of The Daily Value, we examine Consumer Reports’ October 2025 findings on lead in protein powders. The investigation tested 23 products and found that more than two-thirds exceeded the organization’s internal lead safety threshold. We discuss what those results mean in biological terms, how regulatory limits differ between the FDA, EFSA, and Health Canada, and how supplement exposure compares to everyday dietary intake. 00:00 Introduction 00:08 Consumer Reports Investigation ...

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9:27

Coffee: The 2025 Blueprint

Daily Value ·

2025/10/02

October 1st (yesterday) was International Coffee Day. In this episode, we trace coffee’s journey from ancient ritual to modern science. Once a sacred brew in Ethiopia and Yemen, coffee now fuels billions daily. In 2025, research is rewriting how we should drink it. In this episode, we uncover why timing intake, keeping coffee unsweetened, and using the right brewing method matter for long-term health. We also look at new data linking clean coffee to lower risk of chronic liver disease. Coffee...

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13:34

Women and Alzheimer’s: A New Lead

Daily Value ·

2025/08/26

Why are nearly two-thirds of Alzheimer’s patients women? For decades, the explanation seemed simple: women live longer. But the numbers don’t add up. Even after 80, when survival rates even out, women are still more likely to be diagnosed. A new lead may finally expose what’s been hiding in sex-specific biology. 00:00 Introduction: The Alzheimer's Gender Imbalance 00:05 Uncovering Biological Clues 01:39 The Role of Lipid Metabolism 02:47 New Study Sheds Light 03:49 Detailed Findings on Lipi...

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11:35

The Case of the Missing Molecules

Daily Value ·

2025/08/21

Parkinson’s disease has long been defined by the death of neurons in the brain. Yet, decades before tremors appear, the first signs emerge quietly in the gut. Recent evidence reveals a puzzling disappearance: microbial pathways that once produced two well-known compounds fall silent. Their absence strips away protective metabolites, erodes the intestinal barrier, and leaves neurons exposed to toxins that ignite α-synuclein fibrils. Could the vanishing of two simple vitamins be an overlooked t...

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10:16

Two Compounds That Recharge Aging Neurons

Daily Value ·

2025/08/19

In the aging brain, neurons begin to lose a hidden currency. Not just ATP, but GTP - that powers their ability to clear away toxic proteins. Without it, the cleanup crews stall, and amyloid builds up. A team at UC Irvine may have uncovered a way to recharge that system using two familiar compounds. In aged and Alzheimer’s model neurons, this pairing restored GTP, reactivated trafficking pathways, and swept away protein aggregates. In this episode, we follow the trail from dwindling cellular e...

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8:47

The Microbes That Pay Your Energy Bill

Daily Value ·

2025/08/14

Your gut microbes don’t just digest food, they can power you. In this episode, we uncover a hidden energy stream: short-chain fatty acids produced when microbes ferment plant fibers, potentially supplying anywhere from 2% to 10% of your daily calories. A new Cell study quantifies this microbial contribution with a unique level of precision, revealing how dietary choices drives the yield. We look at the mechanisms behind this energy exchange, , and show why increasing fiber intake is one of th...

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12:22

Hidden in the Water: Lithium’s Secret

Daily Value ·

2025/08/12

What if one of the brain’s most important defenses was hiding in plain sight? In this episode, we take a look at lithium, a trace element found in water, food, and the brain itself. Long before brain scans, people made pilgrimages to lithium-rich springs, swearing the waters restored their health. A century later, it became a psychiatric drug. But new research from Harvard Medical School has uncovered something unique: lithium is a master regulator in the brain, and one of the earliest change...

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22:46

The Glutathione-Motivation Link

Daily Value ·

2025/08/05

In this episode of Daily Value, we look into the biochemical foundations of motivation, emphasizing the critical role of glutathione, a primary antioxidant in the brain. Motivation is not merely a psychological trait, it is a metabolically demanding state that depends on the brain’s ability to manage oxidative stress. Central to this defense is glutathione, a tripeptide critical for maintaining redox homeostasis during sustained cognitive effort. In this episode, we look at recent research de...

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18:03

The Neuroscience of Dietary Fiber

Daily Value ·

2025/07/31

In this episode of Daily Value, we look at the surprising connection between dietary fiber and cognitive health. Fiber isn’t just about digestion - it’s a powerful nutrient influencing your brain through the gut-brain axis. We’ll take a look at new research that reveals how optimal fiber intake may physically enhance and/or help maintain the structure of specific brain regions, important for memory and learning. Learn about the different types of fiber, their unique roles, and practical tips ...

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11:25

Optimizing Vitamin Uptake via the Microbiome

Daily Value ·

2025/07/01

In this episode of Daily Value, we evaluate the often-overlooked yet powerful connection between your gut microbiome and vitamin absorption. Going beyond basic nutrition, we’ll break down how gut bacteria directly influence your body's ability to synthesize and efficiently absorb essential vitamins through mechanisms such as transporter protein modulation, enzyme stimulation, and immune regulation. Practical and actionable insights are provided foster optimal gut health and nutritional status...

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19:24

Methylene Blue and the Bioenergetics of Memory

Daily Value ·

2025/06/24

In this episode of Daily Value, we look at the neurometabolic potential of methylene blue, a synthetic dye first synthesized in the 19th century, for supporting brain energy metabolism during aging. Originally developed for textile use, methylene blue has since demonstrated potential use as a redox-active agent in neuroprotection and memory enhancement (and how exactly it performs these actions). We look at it’s unique biochemical mechanism as an alternative electron carrier within the mitoch...

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20:46

The Vitamin C-risis: Why Current Guidelines Fail Us

Daily Value ·

2025/06/19

Today’s episode of Daily Value questions something fundamental—the guidelines that shape our daily vitamin C intake. What if the rules you've been following were set too low, missing a hidden metabolic reality that affects millions? New evidence suggests that current recommendations may underestimate our true biological needs—impacting energy, immune health, and even cognitive clarity. This episode will explore how subtle differences in absorption, cellular retention, and even the form of vit...

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10:06

The Vitamin Link to Neuropsychiatric Disorders

Daily Value ·

2025/06/06

In this episode of Daily Value, we look at the influence of B vitamins on mental health and neuropsychiatric disorders. The discussion is centered around a recently published meta-analysis suggesting a causal link between B vitamin deficiencies and the development of conditions such as Parkinson's disease, schizophrenia, and Alzheimer's disease. Talking points include the distinct impacts of vitamins B12, B6, and B9 (folate) on brain health, their role in one-carbon metabolism, and findings f...

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11:21

Gut Check: The Hidden Role of B Vitamins

Daily Value ·

2025/06/04

In this episode of Daily Value, we look into the research on the relationship between B group vitamins and the human gut microbiome. The discussion focuses on how B vitamins might act as prebiotics, influencing gut health and overall well-being. Talking points include how B vitamins interact with gut bacteria, their potential indirect benefits through cross-feeding, and the controversies around their absorption. 00:00 Introduction to B Group Vitamins and Gut Microbiome 01:14 Understandi...

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14:22

The Antioxidant of Antioxidants: A Compound You're...

Daily Value ·

2025/06/02

In this episode of Daily Value, we look at the often overlooked yet potent nutrient, alpha lipoic acid, which is integral to mitochondrial energy metabolism and cellular health. Discovered in 1937, ALA acts as a primary antioxidant in the body. This episode covers the distinction(s) between supplemental and endogenous ALA. The latter is able to cross the blood-brain barrier and is used therapeutically for conditions like diabetic neuropathy, oxidative stress, and metal detoxification. I will ...

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73 results

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