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PODCAST

Longevity by Design

Gil Blander PhD

Longevity by Design is your go-to podcast for unlocking the secrets to a longer, healthier life. Hosted by Dr. Gil Blander, a renowned scientist and entrepreneur in the fields of aging, nutrition, and personalized health, this show dives into cutting-edge research and practical strategies for optimizing your healthspan and lifespan.In each episode, Dr. Blander sits down with leading longevity and health scientists to explore how we can live better, longer lives. From unpacking complex scientific

health & fitness medicine

All Episodes

59:34

The Gut–Brain Axis: A New Frontier in Longevity with...

Longevity by Design ·

2025/12/03

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Emeran Mayer, Executive Director at the UCLA Center for Neurobiology of Stress and Resilience and founder of Mayer Interconnected. They explore the science behind the gut-brain connection and its role in shaping health and longevity. Emeran explains how signals flow between the brain, gut, and microbiome, influencing everything from digestion to emotions. He breaks down how modern diets, especially ultra-processe...

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69:10

Dr. Barabási Explains Nutritional Dark Matter, Food...

Longevity by Design ·

2025/11/19

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Albert-László Barabási, Professor at Northeastern University, to explore how networks shape health, aging, and nutrition. Barabási explains how biological and social networks influence resilience, robustness, and our ability to recover from stress or disease. He describes aging as a gradual loss of resilience, where the body becomes less able to bounce back from small disruptions. The conversation moves into the ...

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57:26

Building Joyspan: How Purpose and Connection Extend...

Longevity by Design ·

2025/11/05

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Kerry Burnight, Gerontologist, Chief Gerontologist, New York Times best-selling author, and researcher. They explore what it truly means to age well, focusing less on resisting the passage of time and more on embracing vitality, curiosity, and joy throughout life’s second half. Dr. Burnight explains why the common “decline” mindset around aging misses the full story. She shares research showing that meaningful gr...

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63:01

Why Sleep Trumps Exercise for Long-Term Health with...

Longevity by Design ·

2025/10/22

In this episode of Longevity by Design, host Gil Blander sits down with Florence Comite, MD, physician-scientist and founder of the Comite Center for Precision Medicine & Healthy Longevity. They explore why a one-size-fits-all approach to longevity falls short and how personalized data, from biomarkers to genetics, can spot early signs of disease before symptoms appear. Florence explains her “Nof1” method, which uses deep testing, wearables, and personal history to craft precise health p...

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59:33

Building a Blueprint for Longer Lives Through Public...

Longevity by Design ·

2025/10/08

In this episode of Longevity by Design, our host, Dr. Gil Blander, sits down with Dylan Livingston, CEO at the Alliance for Longevity Initiatives, and Dr. Brenda Eap to explore how public policy shapes the future of aging research. Dylan and Brendan share how their team pushes for legislation that supports healthy lifespan extension, aiming to bring longevity science into the center of national health priorities. Dylan and Brendan explain why policy advocacy is crucial for securing funding f...

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67:20

Dr. Peter Fedichev: Why Aging Is Functional Decline,...

Longevity by Design ·

2025/09/17

Aging is more than disease—it’s the steady decline of function. In this episode of Longevity by Design, Dr. Gil Blander speaks with physicist-turned-biotech innovator Dr. Peter Fedichev about why resilience, not diseases, holds the key to longer lives. Peter explains how his background in theoretical physics shaped his approach to biology and aging. He outlines why startups, not large institutions, are now leading innovation in longevity science. Drawing from physics, he describes aging as a...

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52:51

Dr. Eric Verdin on the Effects of Therapeutic Plasma...

Longevity by Design ·

2025/09/03

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks. Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept insp...

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65:14

What Happens to Your Body When You Sit All Day, with...

Longevity by Design ·

2025/08/20

In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting. Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his lab's findings, he shares a simple but powerful prescription: five minutes of light walking every hour. That small change can lower blood pressure, ...

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55:51

Acetylation Insights: Unlocking Longevity Secrets...

Longevity by Design ·

2025/08/06

In this episode, Dr. Gil Blander welcomes Dr. Haim Cohen to Longevity by Design to explore his revolutionary approach to understanding aging. Haim's team analyzed acetylation sites across 107 mammalian species, creating its most extensive comparative study. This computational approach revealed specific post-translational modifications that evolved exclusively in long-lived animals. The research identifies critical pathways where evolution engineered longevity solutions. These acetylation cha...

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78:51

Karl Pfleger Explains the Aging Biotech Explosion

Longevity by Design ·

2025/07/23

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Karl Pfleger, aging biotechnology investor and creator of AgingBiotech.info, to dissect the rapidly evolving field of aging therapeutics. Karl breaks down the sector into two main categories: interventions that slow aging rates versus rejuvenation strategies that repair accumulated damage. Karl highlights the most promising areas in his investment portfolio, including senolytics for clearing senescent cells and epigen...

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73:28

How to Extend Your Healthspan with Dr. Eric Topol

Longevity by Design ·

2025/07/09

Gil and Eric discuss Eric’s book, Super Agers, and the inspiration behind it: a 98-year-old patient who exemplified healthy aging. They explore the five dimensions of healthspan optimization: lifestyle, omics, the immune system, and the role of data and AI in personalized medicine. Eric highlights how AI can analyze multi-layered data to provide personalized recommendations for preventing age-related diseases. The conversation also explores the importance of exercise, sleep, and social conne...

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79:20

The Science of Muscle, Protein, and Longevity:...

Longevity by Design ·

2025/06/18

In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stresses the power of personalized approaches to nutrition and fitness, advocating for a critical approach to information consumption. Layne dives int...

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56:39

Beyond Sick Care: Evelyne Bischof on the Rise of...

Longevity by Design ·

2025/06/04

On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society. Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizing health span, not just lifespan, and how healthy longevity medicine benefits not only individuals, but population health and the world econ...

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51:06

Precision Habits: How Wearables and AI Are Powering...

Longevity by Design ·

2025/05/21

In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity. The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a ...

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82:16

Scanning the Future: How Whole-Body MRI is...

Longevity by Design ·

2025/05/07

Dr. Gil Blander welcomes Dr. Daniel Durand, Chief Medical Officer at Prenuvo, to Longevity by Design for a deep dive into the future of preventative healthcare. Dr. Durand shares how full-body MRI is redefining early detection by making advanced imaging accessible, non-invasive, and radiation-free. He explains why MRI, as a soft tissue imaging modality, offers unmatched insight into early-stage cancers and chronic conditions. The conversation unpacks misconceptions around overdiagnosis and f...

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61:54

AI, LLMs & The Future of Longevity: Unlocking...

Longevity by Design ·

2025/04/16

In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Eran Segal, Professor at the Weizmann Institute of Science, to explore the intersection of artificial intelligence (AI) and personalized health. The conversation dives into how AI and machine learning are transforming our understanding of nutrition, disease prediction, and overall longevity. Eran provides a clear overview of AI, machine learning, and deep learning, explaining how these technologies can be applied to var...

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49:25

GLP-1, Wearables & Longevity: What You Need to Know –...

Longevity by Design ·

2025/04/02

Dr. Gil Blander and Ashley Reaver dive into the science behind GLP-1 agonists, a class of drugs originally developed for type 2 diabetes but now widely used for weight management and longevity. They explore how these medications work, their effects on appetite, metabolism, and inflammation, and why they might be a game-changer for cardiovascular health, brain function, and fertility. While promising, they emphasize the importance of long-term research and consulting with medical professionals...

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78:38

Muscle, Longevity, and the Power of Protein with Dr....

Longevity by Design ·

2025/03/19

In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Gabrielle Lyon, a board-certified family physician and New York Times bestselling author of Forever Strong. Gabrielle discusses the growing epidemic of sarcopenia, the loss of muscle mass and strength, accelerated by the use of GLP-1 medications. She emphasizes the importance of muscle health for overall longevity and introduces the concept of "muscle span." Gil and Gabrielle explore the critical role of skeletal muscl...

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72:52

The Science, Evolution, and Future of Lifespan and...

Longevity by Design ·

2025/03/05

On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens. Michael highlights the challenges and breakthroughs in lon...

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70:08

How Long Can Humans Live? Insights from Dr. Jay...

Longevity by Design ·

2025/02/19

In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Jay Olshansky, a leading professor at the University of Illinois Chicago and a renowned expert in aging and biodemography. Together, they delve into the science of longevity, exploring how public health advancements in the 20th century revolutionized life expectancy and what lies ahead in the quest to extend both lifespan and healthspan. Dr. Olshansky unpacks the biological limits of human longevity, shedding light on...

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43 results

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