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PODCAST

AI + a16z

Artificial intelligence is changing everything from art to enterprise IT, and a16z is watching all of it with a close eye. This podcast features discussions with leading AI engineers, founders, and experts, as well as our general partners, about where the technology and industry are heading.

technology entrepreneurship

All Episodes

00:47:31

Pylon: Reimagining B2B Customer Support

AI + a16z ·

2025/10/31

Customer support platforms lacked adequate solutions for B2B companies - until Pylon entered the scene.We sat down with Pylon cofounders Marty Kausas, Advith Chelikani, and Robert Eng to discuss why they went into B2B, how they plan to beat huge competitors, and why they still live together in a windowless apartment and work 9-9-6 hours despite having raised tens of millions.Follow Pylon on X: https://x.com/usepylonFollow Marty on X: https://x.com/marty_kausasFollow Advith on X:

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00:32:41

Keycard: 2026 is the Year of Agents

AI + a16z ·

2025/10/22

In 2025, we saw the first glimpses of true AI agents. In 2026, every company will be rushing to get them into production, and they’ll need companies like Keycard to manage fleets of agents.In this conversation, a16z Partner Joel de la Garza sits down with Keycard Cofounder and CEO Ian Livingstone to discuss the continuum from copilots to agents, the security realities of tool-calling, why enterprises will adopt before consumers, and how to control your agents. Follow Joel on LinkedIn:

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00:38:06

The Trillion Dollar AI Software Development Stack

AI + a16z ·

2025/10/10

AI coding has emerged as a major market for AI: one that’s already rewriting how software gets built.a16z Infra Partners Yoko Li and Guido Appenzeller break down how “agents with environments” are changing the dev loop; why repos and PRs may need new abstractions; and where ROI is showing up first (like legacy code migration). We also cover token economics for engineering teams, the emerging agent toolbox (sandboxes, code search/parsing, agent-optimized docs, orchestration), and founder

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00:34:26

Material Security CEO: How To Find Your Ideal Customer

AI + a16z ·

2025/10/06

What if the hardest part of building a company isn’t the product, but knowing exactly who it’s for?In this episode, a16z General Partner Martin Casado sits down with Abhishek Agrawal, Cofounder and CEO of Material Security, to discuss how an ideal customer profile is discovered, how to manage any kind of customer, and how frothy markets can distort real signal.Follow Martin on X: https://x.com/martin_casadoFollow Material Security on X: https://x.com/material_secFollow Abhishek on LinkedIn:

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00:22:11

When Deepfakes Steal $30M: The New Edge of Cybercrime

AI + a16z ·

2025/09/26

AI is transforming both sides of the cybersecurity cat-and-mouse game. Attackers are using LLMs to scale impersonation, phishing, and even deepfake fraud—while defenders are racing to automate detection and takedowns at the same speed.In this episode, a16z partner Joel de la Garza talks with Kevin Tian, cofounder & CEO of Doppel Security (and former Uber engineer), about building in this new landscape. They cover:Why outsider founders sometimes build the most effective security companiesThe “3 V’s”

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00:51:41

How AI Will Change Photography Forever

AI + a16z ·

2025/09/17

What if you could retake your favorite memories years after they happened, fixing the lighting, catching the smile, or even opening your eyes?In this conversation, a16z General Partner Martin Casado and Partner Yoko Li sit down with scientist and Lytro founder Ren Ng along with Phota Labs cofounders Cecilia Zhang and Zhihao “Zach” Xia to explore the past, present, and future of computational photography. They trace the story from the invention of light-field cameras and the evolution of smartphone

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01:19:36

How OpenAI Built Its Coding Agent

AI + a16z ·

2025/08/29

OpenAI’s Codex has already shipped hundreds of thousands of pull requests in its first month. But what is it really, and how will coding agents change the future of software?In this episode, General Partner Anjney Midha goes behind the scenes with one of Codex’s product leads- Alexander Embiricos - to unpack its origin story, why its PR success rate is so high, the safety challenges of autonomous agents, and what this all means for developers, students, and the future of coding.Resources: Find Alex

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00:47:15

Models, Modalities, and Memes: Creating Compelling AI...

AI + a16z ·

2025/08/14

Models, Modalities, and Memes: Creating Compelling AI CharactersIn this episode of AI + a16z, Hedra founder and CEO Michael Lingelbach joins a16z partners Justine Moore and Matt Bornstein to talk about building AI-native video — and why the next wave of generative content is all about characters, not just clips.They discuss how Hedra’s expressive, full-body, dialogue-centric video models are powering everything from viral meme content to enterprise training tools. Michael explains why “character” is

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00:40:10

Performance and Passion: Fal's Approach to AI Inference

AI + a16z ·

2025/08/01

If you've been experimenting with image, video, and audio models, the chances are you've been both blown away by how good they're becoming, and also a little perturbed by how long they can take to generate. If you've been using a platform like Fal, however, your experience on the latter point might be more positive.In this episode, Fal cofounder and CEO Burkay Gur and head of engineering Batuhan Taskaya join a16z general partner Jennifer Li to discuss how they built an inference platform — or, as

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00:26:35

How to Vibe Code Securely

AI + a16z ·

2025/07/25

In this episode, a16z partner Joel de la Garza sits down with Socket founder and CEO Feross Aboukhadijeh to dive into the intersection of vibe coding and security. As one of the earliest security founders to fully embrace LLMs, Feross shares firsthand insights into how these technologies are transforming software engineering workflows and productivity — and where there are sharp edges that practitioners need to avoid.The TL;DR: Treat AI-assisted programming the same way you'd treat other

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00:42:52

AI Is Upending SaaS Pricing

AI + a16z ·

2025/07/18

In this episode, a16z GP Martin Casado sits down with Metronome CEO Scott Woody to unpack how AI is fundamentally changing the value proposition of software—and why that shift demands a rethink of the traditional SaaS business model.They explore how, in the cloud era, value scaled with the number of users accessing a shared system (think Salesforce). However, in the AI era, value shifts to the work the software performs on your behalf, automating tasks such as writing code or resolving support

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00:45:33

The AI Infrastructure Stack with Jennifer Li

AI + a16z ·

2025/07/11

In this episode, which originally aired on the Complex Systems Podcast, a16z General Partner Jennifer Li discusses how AI is reshaping every layer of the software stack, creating demand for new types of middleware. Jennifer talks about emerging infrastructure categories and why the next wave of valuable companies might be the unsexy infrastructure providers powering tomorrow's intelligent applications.Subscribe to Complex Systems:SpotifyAppleCheck out everything a16z is doing with artificial

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00:46:48

AI's Unsung Hero: Data Labeling and Expert Evals

AI + a16z ·

2025/06/27

Labelbox CEO Manu Sharma joins a16z Infra partner Matt Bornstein to explore the evolution of data labeling and evaluation in AI — from early supervised learning to today’s sophisticated reinforcement learning loops.Manu recounts Labelbox’s origins in computer vision, and then how the shift to foundation models and generative AI changed the game. The value moved from pre-training to post-training and, today, models are trained not just to answer questions, but to assess the quality of their own

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00:35:07

AI, Data Engineering, and the Modern Data Stack

AI + a16z ·

2025/06/20

In this episode of AI + a16z, dbt Labs co-founder and CEO Tristan Handy sits down with a16z's Jennifer Li and Matt Bornstein to explore the next chapter of data engineering — from the rise (and plateau) of the modern data stack to the growing role of AI in analytics and data engineering. As they sum up the impact of AI on data workflows: The interesting question here is human-in-the-loop versus human-not-in-the-loop. AI isn’t about replacing analysts — it’s about enabling self-service across the

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00:26:02

Enabling Agents and Battling Bots on an AI-Centric Web

AI + a16z ·

2025/06/13

Arcjet CEO David Mytton sits down with a16z partner Joel de la Garza to discuss the increasing complexity of managing who can access websites, and other web apps, and what they can do there. A primary challenge is determining whether automated traffic is coming from bad actors and troublesome bots, or perhaps AI agents trying to buy a product on behalf of a real customer.Joel and David dive into the challenge of analyzing every request without adding latency, and how faster inference at the edge

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00:35:49

Giving New Life to Unstructured Data with LLMs and...

AI + a16z ·

2025/06/06

Instabase founder and CEO Anant Bhardwaj joins a16z Infra partner Guido Appenzeller to discuss the revolutionary impact of LLMs on analyzing unstructured data and documents (like letting banks verify identity and approve loans via WhatsApp) and shares his vision for how AI agents could take things even further (by automating actions based on those documents). In more detail, they discuss:Why legacy robotic process automation (RPA) struggles with unstructured inputs.How Instabase developed

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01:41:43

Beyond Leaderboards: LMArena’s Mission to Make AI...

AI + a16z ·

2025/05/30

LMArena cofounders Anastasios N. Angelopoulos, Wei-Lin Chiang, and Ion Stoica sit down with a16z general partner Anjney Midha to talk about the future of AI evaluation. As benchmarks struggle to keep up with the pace of real-world deployment, LMArena is reframing the problem: what if the best way to test AI models is to put them in front of millions of users and let them vote? The team discusses how Arena evolved from a research side project into a key part of the AI stack, why fresh and subjective

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00:47:40

Building AI Systems You Can Trust

AI + a16z ·

2025/05/23

In this episode of AI + a16z, Distributional cofounder and CEO Scott Clark, and a16z partner Matt Bornstein, explore why building trust in AI systems matters more than just optimizing performance metrics. From understanding the hidden complexities of generative AI behavior to addressing the challenges of reliability and consistency, they discuss how to confidently deploy AI in production. Why is trust becoming a critical factor in enterprise AI adoption? How do traditional performance metrics fail

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00:44:30

Who's Coding Now? AI and the Future of Software...

AI + a16z ·

2025/05/16

In this episode of the a16z AI podcast, a16z Infra partners Guido Appenzeller, Matt Bornstein, and Yoko Li explore how generative AI is reshaping software development. From its potential as a new high-level programming abstraction to its current practical impacts, they discuss whether AI coding tools will redefine what it means to be a developer.Why has coding emerged as one of AI's most powerful use cases? How much can AI truly boost developer productivity, and will it fundamentally change

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00:53:39

MCP Co-Creator on the Next Wave of LLM Innovation

AI + a16z ·

2025/05/02

In this episode of AI + a16z, Anthropic's David Soria Parra — who created MCP (Model Context Protocol) along with Justin Spahr-Summers — sits down with a16z's Yoko Li to discuss the project's inception, exciting use cases for connecting LLMs to external sources, and what's coming next for the project. If you're unfamiliar with the wildly popular MCP project, this edited passage from their discussion is a great starting point to learn:David: "MCP tries to enable building AI applications in such a way

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62 results

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