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PODCAST

Health Optimization Medicine Podcast

Health Optimization Medicine and Practice

The Health Optimization Medicine Podcast is dedicated to offering one-cent solutions to life"s $64,000 questions across health optimization, decision-making, consciousness, performance, and human potential. Produced by Health Optimization Medicine & Practice (HOMeHOPe) and Smarter Not Harder, Inc., the makers of Troscriptions, this podcast bridges rigorous science with real-world clinical application. Each episode features in-depth conversations with leading researchers, clinicians, and original

science life sciences

All Episodes

47:27

Eye Health & Vision Optimization w/ Dr. Bryce...

Health Optimization Medicine Podcast ·

2026/09/30

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Bryce Appelbaum to discuss the connection between vision, screen time, brain function, and nervous system regulation. Most people think of vision as eyesight, or how clearly they can see an eye chart. Dr. Appelbaum explains why vision is much broader. It involves how the brain receives information through the eyes, interprets the environment, coordinates movement, and decides how to respond. The

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16:18

Unlock Your Brain with Better Glymphatic Clearance |...

Health Optimization Medicine Podcast ·

2026/09/23

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval explore the glymphatic system and the role sleep plays in clearing metabolic waste from the brain. Getting eight hours of sleep does not necessarily mean getting eight hours of effective brain clearance. The team looks at how the autonomic nervous system, norepinephrine, cerebrospinal fluid and interstitial fluid exchange, aquaporin-4 channels, circadian timing, body temperature, gut

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14:15

The Cellular Mechanisms of Stress | HOMe Podcast #027

Health Optimization Medicine Podcast ·

2026/09/16

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Jodi Duval, and Dr. Allen Bookatz explore what happens inside the cell when the body perceives stress or danger. The discussion focuses on Dr. Robert Naviaux's Cell Danger Response and how mitochondria can alter energy production and signaling in response to perceived threats. The team examines why fatigue, brain fog, inflammation, and exercise intolerance can occur even when standard laboratory testing appears normal, and

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10:34

Read Your Genes! APOE4, Brain Health, and Longevity |...

Health Optimization Medicine Podcast ·

2026/09/09

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Jup Kuipers, Boomer Anderson, Dr. Allen Bookatz, and Dr. Scott Sherr explore a difficult question: can we influence the biology of an aging brain carrying APOE4 risk? APOE4 is not simply a diagnosis, and a genetic result does not tell us what is happening in someone's brain today. The team looks at how APOE4 may affect lipid transport, microglial behavior, vascular integrity, glucose utilization, mitochondrial

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14:14

Why You're Frozen in Survival Mode: Understanding CDR...

Health Optimization Medicine Podcast ·

2026/09/02

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, and Jodi Duval sit down to discuss what happens when the body's cellular defense systems remain activated after the original threat has passed. Fatigue and brain fog are often treated as problems that require more stimulation, more exercise, or more supplements. But what if low energy is sometimes an adaptive response? The HOMeHOPe faculty explores the Cell Danger Response, how

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15:16

Can Creatine Protect the Brain from Sleep...

Health Optimization Medicine Podcast ·

2026/08/26

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Dr. Jup Kuipers explore how acute sleep deprivation affects brain energy metabolism and whether creatine monohydrate can help preserve cognitive function when sleep loss is unavoidable. Rather than relying on stimulants like caffeine or modafinil to push through fatigue, the team examines whether directly supporting the brain's phosphocreatine and ATP systems can maintain cellular

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15:08

The Real Cause of Endotoxemia: Leaky Gut Explained |...

Health Optimization Medicine Podcast ·

2026/08/19

In this episode of the Health Optimization Medicine Podcast, Boomer Anderson, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers explore a misunderstood cause of chronic fatigue and leaky gut: the bioenergetic failure of your colonocytes. While many practitioners throw random probiotic strains and anti-inflammatory herbs at gut issues, metabolomic research shows this approach fails to address the root problem. The team explains how a starved microbiome forces gut cells to switch energy

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23:39

Is Your Cellular Membrane Leaking the Fuel That Keeps...

Health Optimization Medicine Podcast ·

2026/08/12

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane. While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests these compounds cannot overcome a damaged mitochondrial membrane. The team explains how age-related

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52:39

Dr. Dominic D'Agostino Explains What Ketones Actually...

Health Optimization Medicine Podcast ·

2026/08/05

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr sits down with Dr. Dominic D'Agostino, the premier researcher in ketogenic metabolic therapies. Moving past the mainstream fads of keto ice cream and internet trends, they break down how exogenous ketones actually impact cellular energy, cardiovascular health, and environmental stress. From the liver toxicity associated with certain high-dose ketone esters to the hidden vasodilatory superpowers of L-BHB, this discussion

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18:47

Metformin is Poisoning Your Cells | HOMe Podcast #020

Health Optimization Medicine Podcast ·

2026/07/29

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Jodi Duval, and Dr. Jup Kuipers take a deep dive into the shocking new 21-year pre-diabetes follow-up study (DPPOS) published in the Journal of the American Medical Association on June 15, 2026. Moving past the mainstream longevity hype surrounding Metformin as an anti-aging cure-all, the faculty breaks down why chemically poisoning your enzymes is a profound mismatch for healthy,

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32:18

The Gut-Brain-Microbiome Axis: Understanding...

Health Optimization Medicine Podcast ·

2026/07/22

In this episode of the Health Optimization Medicine Podcast, Dr. Ted Achacoso, Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Jup Kuipers, and Jodi Duval take a deep dive into the gut-brain-microbiota axis. Moving past the simplistic, pathogenic "pill-for-an-ill" approach of conventional psychiatry and the mainstream hype around over-the-counter probiotics, the faculty breaks down why establishing enteric safety must always precede biochemical optimization. Join us as we delve into: The Tripartite Axis:

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26:38

Why You Can't Out-Supplement a Dysregulated Nervous...

Health Optimization Medicine Podcast ·

2026/07/15

In this episode of the Health Optimization Medicine Podcast, Dr. Allen Bookatz, Dr. Ted Achacoso, and Jodi Duval tackle the widespread trend of supplement fatigue. As biohacking becomes a mindset of treating symptoms with heavy stimulants and endless pills, the faculty breaks down why forcing adaptation on an exhausted system only drives the body deeper into a chronic state of inflammatory defense. From the biophysics of the Cell Danger Response (CDR1) to practical parasympathetic upregulation, this

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21:26

Cellular Safety and the Dangers of Mechanical Blood...

Health Optimization Medicine Podcast ·

2026/07/08

In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma exchange and "blood washing". Moving past the mainstream marketing of plasmapheresis as a longevity cure-all, the team breaks down why mechanical filtering is only a surface-level fix for microplastic toxicity. From the autonomic anxiety caused by biological lockdown to the clinical application

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21:16

The HRV Paradox: Why Tracking Your Sleep Makes It...

Health Optimization Medicine Podcast ·

2026/07/01

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, and Jodi Duval) tackles one of the most paradoxical trends in modern biohacking: sleep tracking. Moving past the mainstream obsession with daily device scores, the team breaks down the biochemical realities of how tracking your HRV might actually be sabotaging your sleep architecture. From the autonomic anxiety caused by digital wearables to the clinical application

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15:28

Decoding the Holobiont: The Ecosystem of Ecosystems |...

Health Optimization Medicine Podcast ·

2026/06/24

In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont. Moving away from the traditional, siloed medical model of "organology" (treating the heart, gut, and brain as isolated systems managed by different specialists), the faculty discusses why true health optimization requires viewing the human body as a complex, interconnected ecosystem of ecosystems. Join us as we delve

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15:28

Bypass the Fiber Trend & Optimize Your Gut Health

Health Optimization Medicine Podcast ·

2026/06/17

In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern nutrition: fiber. Moving past the mainstream trend of "fiber-maxing," the team breaks down the actual biochemical realities of how different forms of fiber interact with your unique gut microbiome. From the surprising hormonal impacts of over-consuming fiber to the rise of localized conditions,

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13:44

Chronic Disease is Aging | HOMe Podcast #014

Health Optimization Medicine Podcast ·

2026/06/10

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging. Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how

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24:37

Health Optimization for Parenting, Pregnancy & Family...

Health Optimization Medicine Podcast ·

2026/06/03

In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty, they dive deep into the specific biology of preconception, pregnancy, and pediatric health optimization. Moving beyond typical disease management, they explore how to foster both psychological and cellular safety across the entire family unit. Join us as we delve into: The Masterclass

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32:38

What Nobody Told You About Your Gut | HOMe Podcast #012

Health Optimization Medicine Podcast ·

2026/05/27

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system. 𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘀 𝘄𝗲 𝗱𝗲𝗹𝘃𝗲 𝗶𝗻𝘁𝗼: •The "tripartite axis" (Gut-Brain-Enteric

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25:22

Overcompensation and Over-Optimization without Proper...

Health Optimization Medicine Podcast ·

2026/05/20

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Allen Bookatz, and Dr. Jup Kuipers come together live in studio in Washington, D.C. to discuss the dangers of over-optimization and the "more is better" mentality. They explore real clinical case studies of patients who inadvertently damaged their health by blindly following supplement trends. Join us as we delve into: The dangers of over-supplementing with high-dose Fish Oil and Vitamin B6. How shifting to an

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