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PODCAST

Physiological Reviews Podcast

American Physiological Society

Each episode of the Physiological Reviews podcast features commentary and discussion of newly published articles in the journal, which provides state-of-the-art, comprehensive, and high-impact coverage of timely issues in the physiological and biomedical sciences. Physiological Reviews articles appeal to physiologists, neuroscientists, cell biologists, biophysicists, and clinicians with special interest in pathophysiology. The journal is very useful in teaching and research because it provides

science life sciences

All Episodes

30:38

Forward and Reverse Cardio-oncology

Physiological Reviews Podcast ·

2025/10/24

What is the difference between forward and reverse cardio-oncology? In our latest episode, Deputy Editor Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Rudolf de Boer (Erasmus Medical Center) about the new Review article by Meijers et al. Forward cardio-oncology focuses on cardiotoxicity and cardiac damage due to anti-cancer therapies in patients with prevalent cancer. In contrast, reverse cardio-oncology describes the phenomenon that cancer is more often discovered in patients with

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39:51

Immunotherapy for Atherosclerosis

Physiological Reviews Podcast ·

2025/09/12

What role does inflammation play in atherosclerosis? In our latest episode of The Physiological Reviews Podcast, Dr. Carol Ann Remme talks with authors Dr. Esther Lutgens (Mayo Clinic) and Dr. Claudia Monaco (University of Oxford) about their recent Review on immunotherapy for atherosclerosis. The authors discuss the network of multiple immune cell types and subsets of the innate and adaptive immune system that occupy arteries. In addition, Monaco et al. discuss local inflammation in the arterial

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35:38

Cerebral Small Vessel Disease

Physiological Reviews Podcast ·

2025/05/21

What is cerebral small vessel disease and why is it such a critical area of research? In this episode, Associate Editor Dr. Scott Earley (University of Rochester) interviews author Dr. Anne Joutel (Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris, INSERM) about the pathogenic diagnosis and molecular basis of cerebral small vessel disease (cSVD). Classified into two categories, cerebral amyloid angiopathy (CAA) and nonamyloid cSVD, cSVD is a major health problem responsible

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34:36

The Calculating Brain

Physiological Reviews Podcast ·

2025/05/20

In this episode, Dr. Jan Born (University of Tübingen) interviews his colleague and author Dr. Andreas Nieder (University of Tübingen) about his recent Review in Physiological Reviews on mathematical reasoning that incorporates neurobiology, comparative physiology, and neurophysiology. Mathematical skills can be described as falling into symbolic (arithmetic, number theory) and non-symbolic (set size) representations of numerical quantities. Infants as young as 2 days old can discriminate set size,

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14:51

Molecular Dissection of the Role of ACE2 in Glucose...

Physiological Reviews Podcast ·

2025/04/22

In the episode, Dr. Willis K. “Rick” Samson (Saint Louis University School of Medicine) interviews lead author Dr. Eric Lazartigues (Louisiana State University Health Sciences Center) about the recent Review by Chhabra et al. on the latest discoveries related to the role of ACE2 in glucose homeostasis and regulation of metabolism. What are the consequences, in terms of pancreatic function and glucose homeostasis, for ACE2 knockout animals compared to animals used in overexpression studies? Listen

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55:13

The Liver as a Central Hub of the Immune System

Physiological Reviews Podcast ·

2025/02/28

In the episode, Dr. Mark Donowitz (Johns Hopkins School of Medicine) interviews Dr. Pietro Invernizzi (IRCCS Fondazione San Gerardo dei Tintori; University of Milano-Bicocca) and Dr. Vincenzo Ronca (University of Birmingham; Humanitas University) about their recent Review article that describes the immune function of the liver. Listen as these experts discuss immune tolerance in the liver, sex differences related to this immune tolerance, as well as new technological developments applied to the

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34:24

Neurobiology of Parenting and Infant-Evoked Aggression

Physiological Reviews Podcast ·

2024/12/05

In the episode, Dr. Sadis Matalon (University of Alabama Birmingham) interviews Dr. Catherine Dulac (Howard Hughes Medical Institute, Center for Brain Science, Harvard University) about the new Review in Physiological Reviews by Kaplan et al., which explores the neural basis of the complex social behavior of parenting. Parenting behavior is absolutely essential for the development of human beings and animal species. All humans and animals will experience the impact of parenting behavior on their

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45:23

Proteomics of the Heart

Physiological Reviews Podcast ·

2024/11/21

In the episode, Dr. Carol Ann Remme (University of Amsterdam) and Dr. Sadis Matalon (University of Alabama Birmingham) interview Dr. Jenny Van Eyk (Cedars-Sinai) about the Review in Physiological Reviews by Karpov et al. that dives into proteomics of the heart. Given that proteins are the building blocks of life, studying only genetic data or RNAseq data may offer researchers a somewhat narrow view. Proteomics looks broader, and broader is better, according to Dr. Van Eyk. However, this means that

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49:38

Neurobiology and Systems Biology of Stress Resilience

Physiological Reviews Podcast ·

2024/11/04

What are the biological, neural, and psychological mechanisms of resilience to trauma, stress, and adversity? In this episode, Dr. Jan Born (University of Tübingen) interviews Dr. Raffael Kalisch (Leibniz Institute for Resilience Research) about the open access Review in Physiological Reviews by Kalisch et al. By unraveling the protective mechanisms of stress resilience, the authors hope to find new and better ways to improve therapies for stress-related disorders such as anxiety, depression, and

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36:45

Xenotransplantation from Genetically Modified Pigs to...

Physiological Reviews Podcast ·

2024/06/17

In our latest episode, Physiological Reviews Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews authors Dr. Leigh Peterson (Executive Vice President for Product Development and Xenotransplantation at United Therapeutics Corporation) and Professor Sir Magdi Yacoub (Professor of Cardiothoracic Surgery at the National Heart and Lung Institute at Imperial College London, and Founder and Director of Research at the Harefield Heart Science Centre and Aswan Heart Centre)

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47:07

Community-Acquired Bacterial Coinfections and COVID-19

Physiological Reviews Podcast ·

2024/04/25

In our latest episode, Dr. Farrah Kheradmand (Baylor College of Medicine) interviews Dr. Kevin Harrod (University of Alabama at Birmingham) about his article by Patton et al. on community-acquired bacterial coinfections and COVID-19. In the early days of the pandemic when physicians were treating critically ill COVID patients, there was no standard definition for bacterial coinfections in this cohort. However, as the field has moved forward with understanding how bacterial coinfections contribute

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30:45

Sex Differences in Blood Pressure Regulation and...

Physiological Reviews Podcast ·

2024/04/11

The topic of hypertension is of paramount clinical importance as a significant risk factor for cardiovascular disease, myocardial infarction, stroke, and kidney disease. Sex differences in blood pressure regulation play a major role in the pathophysiology of hypertension. In the episode, Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Thu Le (University of Rochester) about her new Review in Physiological Reviews on the renal, hemodynamic, and hormonal mechanisms of sexual dimorphism in

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01:06:23

Amyloid beta-Peptide and Oxidative Stress in...

Physiological Reviews Podcast ·

2024/01/30

In this episode of The Physiological Reviews Podcast, Professor Giovanni Mann (King’s College London) interviews authors Prof. Marzia Perluigi (Sapienza University of Rome) and Prof. D. Allan Butterfield (University of Kentucky) about their recently published Review on the oxidative stress hypothesis of Alzheimer Disease. The authors provide a comprehensive overview of amyloid beta-peptide associated mechanisms, the use of redox proteomics to define roles of lipid and protein oxidation, and the

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36:55

AI in Physiology and Healthcare

Physiological Reviews Podcast ·

2023/09/20

As Sir Winston Churchill once said, “Where there is great power, there is great responsibility.” This is the overarching context of our latest episode about the future of artificial intelligence (AI) in physiology and healthcare. Listen as host Dr. Ryan Melvin (University of Alabama at Birmingham) interviews author Dr. James Zou (Stanford University) about the Review by Zhang et al. on “Leveraging Physiology and Artificial Intelligence to Deliver Advancements in Healthcare AI in Physiology and

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28:08

The Molecular Athlete: Exercise Physiology from...

Physiological Reviews Podcast ·

2023/08/29

What are the key physiological adaptations attained in exercise regimens used by elite athletes to achieve peak performance? In our latest episode of The Physiological Reviews Podcast, Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews author and Physiological Reviews Associate Editor Dr. Christoph Handschin (University of Basel, Switzerland) about the new Review by Furrer et al. As Dr. Handschin explains, the basis of all types of muscle adaptations is repeated

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23:51

Genome-wide Association Studies of Cardiovascular...

Physiological Reviews Podcast ·

2023/06/01

Genetics studies, including genome-wide association studies (GWAS), play an increasingly important role in physiology and pathophysiology studies of cardiovascular disease. Listen as Deputy Editor Dr. Carol Ann Remme interviews authors Prof. Jeanette Erdmann (University of Lübeck, Germany) and Prof. Connie Bezzina (Amsterdam University Medical Center, Netherlands) about their latest Review in Physiological Reviews by Walsh et al. GWAS are aimed at identifying genetic variants for specific traits,

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33:07

Effects of Climate Change on Ozone and UV-B

Physiological Reviews Podcast ·

2023/04/25

How do changes in concentration of stratospheric ozone impact human health and the global ecosystem? In our latest episode Editor-in-Chief Dr. Sadis Matalon interviews lead author Professor Christos Zerefos about the recent Review titled, “The long-term variability of human health related solar ultraviolet-B radiation doses from the 1980s to the end of 21st century.” Because stratospheric ozone is the protective layer which screens harmful UV-B solar radiation, ozone depletion impacts diseases of

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28:21

Human Frailty and Its Modulation by Physical Activity

Physiological Reviews Podcast ·

2023/02/02

Physiological Reviews Associate Editor Prof. Christoph Handschin speaks with Prof. Paul L. Greenhaff and Prof. Janet M. Lord about their article “Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity,” published in the April 2023 issue of Physiological Reviews.Prof. Greenhaff is Professor at the School of Life Sciences at the University of Nottingham and is deputy director of the Medical Research Council (MRC)-Versus Arthritis Centre for Musculoskeletal

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29:10

A Systematic Review of the Biological Mediators of...

Physiological Reviews Podcast ·

2023/01/04

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Dr. Paule V. Joseph about her article “A Systematic Review of the Biological Mediators of Fat Taste and Smell,” the first systematic review to be published in Physiological Reviews. Dr. Joseph is Lasker Clinical Research Scholar, Tenure Track Clinical Investigator, and Chief of the Section of Sensory Science and Metabolism in the Division of Intramural Clinical and Biological Research at the National Institute of Alcohol Abuse and

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28:29

Systematic Reviews for Basic Scientists: A Different...

Physiological Reviews Podcast ·

2022/12/02

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Prof. John P.A. Ioannidis about his editorial “Systematic Reviews for Basic Scientists: A Different Beast,” which focuses on the importance of systematic reviews in scientific research. Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science at Stanford University. He is one of the most cited scientists in the world and is an elected member of

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