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PODCAST

The Stem Cell Report with Janet Rossant

Stem cell science has catapulted to the forefront of biomedical research over the last decade, bringing with it the potential to transform human health and the treatment of devastating diseases and disorders. Janet Rossant, an internationally recognized stem cell pioneer and the dynamic editor-in-chief of Stem Cell Reports, explores basic discoveries in stem cell research and its application. Dr. Rossant goes “beyond the paper,” bringing authors together to draw new insights and explore the

science life sciences

All Episodes

29:52

Crossing the Border: Modeling the Blood Brain Barrier

The Stem Cell Report with Janet Rossant ·

2025/10/23

The blood-brain barrier (BBB), formed by brain endothelial cells, pericytes, and astrocytes, is organized into a neurovascular unit that regulates the exchange of proteins between blood circulation and brain parenchyma. Human stem-cell-based models using brain endothelial cells are a powerful tool to investigate how disease-related conditions might affect the blood-brain barrier integrity. However, the cell type composition is critical to faithfully model transcytosis across the blood-brain b...

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33:22

Movin’ On Out: Mobilizing HSCs From The Bone Marrow

The Stem Cell Report with Janet Rossant ·

2025/09/22

Hematopoietic stem cells (HSCs) normally reside in the bone marrow niche but can traffic across the bone marrow endothelium into the bloodstream to populate different niches. This process of HSC mobilization from the bone marrow to the blood, is an increasingly favored procedure to obtain HSCs for hematopoietic cell transplantation therapy. Though mobilization is robust in many donors due to years of refined protocols and drug combinations, the process remains difficult or contraindicated amo...

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45:34

Cancer Neuroscience, Tumor Organoids, and...

The Stem Cell Report with Janet Rossant ·

2025/08/12

The role of neuronal influences on cancer pathogenesis and progression is increasingly appreciated in the nervous system. Neurons have been shown to enhance the proliferation and migration of gliomas, a glial-derived tumor of the CNS, via diffusible paracrine factors or synaptic inputs onto tumor cells. In glioblastomas, a highly aggressive glioma, mostly glutamatergic inputs have been identified. While the potential for glioblastomas to receive projections from neurons of other neurotransmit...

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39:52

Stem Cells in Space: Muscle Regeneration in Microgravity

The Stem Cell Report with Janet Rossant ·

2025/07/08

Skeletal muscle is one of the most abundant tissues in the human body, representing approximately 40% of body weight. Under certain circumstances, skeletal muscle can be regenerated through satellite cells, a reservoir of quiescent muscle stem cells, that can be activated with injury or in certain diseases and give rise to newly formed multi-nucleated myotubes and myofibers. However, the regenerative potential of muscle is diminished or is completely absent in the course of normal aging, cert...

en-us

38:33

Parkinson's Disease, Cell Therapy, and Exercise

The Stem Cell Report with Janet Rossant ·

2025/05/13

The potential of pluripotent stem cells and the ability to scale and differentiate them to generate large numbers of enriched cell populations has created new opportunities and approaches to treat human disease. Preclinical proof-of-principle data demonstrates that stem cell-derived neural grafts can be used to reverse symptoms of multiple neurological conditions, including Parkinson’s Disease. Cell grafts enriched with dopaminergic neurons, can structurally and functionally integrate in the ...

en-us

54:08

Leaving an Imprint: The Function, Impact, and...

The Stem Cell Report with Janet Rossant ·

2025/04/07

Parent-specific epigenetic marks (imprints) leading to parent-specific gene expression are crucial for normal growth and development, yet their mechanisms of establishment and maintenance are not fully understood. In humans, approximately 200 imprinted genes have been discovered, and improper imprinting can manifest in growth restriction, obesity, intellectual disabilities, behavioral abnormalities, and an increased risk of certain cancers. While the use of pluripotent stem cells, especially ...

en-us

43:27

Don’t Dull the SPARCL: The Lung Microvasculature and...

The Stem Cell Report with Janet Rossant ·

2025/03/20

The mature lung in both humans and mice is highly vascularized, with approximately 30% of all cells being endothelial cells (ECs). The blood vessels have a physiological role in gas exchange within the tissue, but the vascular cells have additional role(s) beyond supplying oxygen and nutrients to the tissue. For example, the adult lung endothelium responds to injury by activating pathways for alveolar re epithelialization and during embryonic development, disrupting vascularization ex v...

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57:40

A Look Into the Future of Stem Cell Reports: A...

The Stem Cell Report with Janet Rossant ·

2025/01/13

In this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees as some of the exciting prospects over the horizon for stem cell research. We will also talk with Yvonne Fisher, the journal’s Managing Editor, and Jack Mosher of the ISSCR, about the evolution of the journal and its role in the Society. GuestsJanet Rossant is the new Editor-in-Chief of Stem Cell Reports. She holds a...

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34:28

SeqVerify: A New Easily Accessible Tool for...

The Stem Cell Report with Janet Rossant ·

2024/12/09

During the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, mutations, on-target and off-target editing errors, and microbial contamination can arise during PSC culture or due to undesired editing outcomes. To ensure valid experimental results and the safety of PSC-derived therapeutics, it is important to detect...

en-us

53:47

Guidelines for Managing and Using the Digital...

The Stem Cell Report with Janet Rossant ·

2024/11/12

The ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and disease. As a result, these cells are shared, edited, and differentiated by laboratories across the world for basic research, clinical translation, and commercial applications. Large and genotypically diverse collections of pluripotent stem cells are being generated to support large cohort-scale research into conditions s...

en-us

42:54

PSC Developmental Bias: The Mechanism and the...

The Stem Cell Report with Janet Rossant ·

2024/10/25

Pluripotent stem cells are defined, in part, by their potential to generate cell types from all three embryonic germ layers. However, it is well known within the field that there is variability in developmental potential between cell lines. This phenomenon, sometimes referred to as lineage bias, is manifest in a variable response of individual cell lines to induction of differentiation into a specific germ layer lineage. Although lineage bias in pluripotent stem cells has been reported for so...

en-us

39:52

Aging, Stem Cells, and Biological Clocks

The Stem Cell Report with Janet Rossant ·

2024/09/10

Epigenetic clocks based on tissue DNA methylation analysis have emerged as robust and powerful biomarkers of aging. This technology has allowed scientists to investigate how diseases affect the aging process, to evaluate the effectiveness of therapeutic aging interventions, and to correlate age with overall health among the general public. Today you can even purchase test kits online that enable you to measure your own biological age. However, despite the growing use of epigenetic...

en-us

51:38

Evaluating the Expanding Models of Brain Disease

The Stem Cell Report with Janet Rossant ·

2024/08/12

Those who study neurological diseases and their underlying cellular and molecular mechanisms have a number of scientific models at their disposal. In vivo animal models, particularly those bearing targeted genetic modifications, remain the gold standard, especially when it comes to assessment of behavioral readouts and neurobiological disease mechanisms in vivo. Historically, animal models have been widely used for preclinical validation of drug efficacy and safety. Increasingly there i...

en-us

30:40

Going Out on a LIM: Rethinking the Role of LMX1A in...

The Stem Cell Report with Janet Rossant ·

2024/06/11

This episode of The Stem Cell Report will discuss the process of directing stem cells to acquire the proper identity, an essential step in the development of effective and durable cell replacement therapies. Specifically, we will talk about the process of directing cells into a ventral mesencephalic dopaminergic fate for treating Parkinson’s disease. GuestsAgnete Kirkeby is an Associate Professor in the Department of Neuroscience at the University of Copenhagen, a Principal Investigator ...

en-us

37:49

No Oligo Monopoly: Oligodendrocyte Precursor Cells in...

The Stem Cell Report with Janet Rossant ·

2024/05/20

Myelination is one of the last events during mammalian brain development and is thought to continue into young adulthood in humans. Even in adulthood, ongoing low-level myelination is essential for neural homeostasis, and for dynamic processes such as learning and memory. Deficits in myelination resulting in abnormal white matter and disruption of neuronal function are observed in a wide variety of disorders of the CNS. One strategy for alleviating these deficits is to enhance the genesis of ...

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24:35

Enhancing Connections: Rebuilding Neural Circuits in...

The Stem Cell Report with Janet Rossant ·

2024/04/09

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43:07

Climbing the Scientific Mountain of Retinal Regeneration

The Stem Cell Report with Janet Rossant ·

2024/03/11

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37:32

Human Fetal Tissue: A Legacy of Biomedical Research...

The Stem Cell Report with Janet Rossant ·

2024/02/12

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48:39

The Selling of Stem Cells

The Stem Cell Report with Janet Rossant ·

2023/11/13

en-us

52:44

Setting the Standards for Human Stem Cell Research

The Stem Cell Report with Janet Rossant ·

2023/09/12

en-us

43 results

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