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Clinical Gastroenterology and Hepatology

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Issue Highlights - June 2020

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2020/06/01

Rapid Recurrence of Eosinophilic Esophagitis Activity After Successful Treatment in the Observation Phase of a Randomized TrialAssociation Between Indefinite Dysplasia and Advanced Neoplasia in Patients With Inflammatory Bowel Diseases Undergoing Surveillance Healthcare Costs of Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease Are Nearly Twice Those of Matched Controls Significance of Liver Stiffness Changes on Magnetic Resonance Elastography In Primary Sclerosing

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Issue Highlights - May 2020

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2020/05/01

Nutritional Risks in Adolescents After Bariatric Surgery Gene Variants That Affects Levels of Circulating Tumor Markers Increase Identification of Patients With Pancreatic Cancer Stopping 5-ASA Therapy in Patients With Crohn’s Disease Starting Biologic Therapy Does Not Increase Risk of Adverse Outcomes Including Relative Adrenal Insufficiency in the Definition and Classification of Acute-on-Chronic Liver Failure

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Issue Highlights - April 2020

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2020/04/01

Clinical Factors Associated With Gastric Cancer in Individuals With Lynch Syndrome Low Incidence of Aerodigestive Cancers In Patients With Negative Results From Colonoscopies, Regardless of Findings From Multitarget Stool DNA Tests Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients With Nonalcoholic Fatty Liver Disease Effects of Pancreatic Enzyme Replacement Therapy on Body Weight and Nutritional Assessments After Pancreatoduodenectomy in a Randomized

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Issue Highlights - March 2020

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2020/03/01

Monitoring a Combination of Calprotectin and Infliximab Identifies Patients with Mucosal Healing of Crohn’s Disease Best Practices in Teaching Endoscopy Based on a Delphi Survey of Gastroenterology Program Directors and Endoscopy Education Experts in Endoscopy Education Diagnostic Yield of One-Time Colonoscopy vs One-Time Flexible Sigmoidoscopy vs Multiple Rounds of Mailed Fecal Immunohistochemical Tests in Colorectal Cancer Screening GALAD Score Detects Early Hepatocellular Carcinoma in an

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Issue Highlights - February 2020

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2020/02/01

Optimizing Outcomes of Single-operator Cholangioscopy-guided Biopsies: Results of a Randomized Trial Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients With Crohn’s Disease Not Suspected of Having Perianal Fistulas Efficacy of Epicutaneous Immunotherapy in Children With Milk-Induced Eosinophilic Esophagitis Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries Risk Of Gastrointestinal Bleeding

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Issue Highlights - September 2019

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2019/09/01

Clinical Characteristics and Outcomes of Patients With Postfundoplication Dysphagia Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-Associated Genes in Patients With Multiple Colorectal Polyps Clopidogrel and Low-Dose Aspirin, Alone or Together, Reduce Risk of Colorectal Cancer Health-related Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation

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Issue Highlights - August 2019

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2019/08/01

Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases Upfront Combination Therapy, Compared With Monotherapy for Patients Not Previously Treated With a Biologic Agent Associates With Reduced Risk of Inflammatory Bowel Disease-Related Complications in a Population-based Cohort Study Statin Use Is Associated With Improved Outcomes of Patients With Primary Sclerosing Cholangitis Cost Effectiveness of Hepatocellular Carcinoma Surveillance

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Issue Highlights - July 2019

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2019/07/01

Combination Therapy With Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy: A Post Hoc Analysis Safety of Tofacitinib for Treatment of Ulcerative Colitis, Based on 4.4 Years of Data From Global Clinical Trials Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease Preoperative Endoscopic Retrograde Cholangiopancreatography Is Not Associated With Increased Pancreatic Cancer

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Issue Highlights - June 2019

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2019/06/01

Rebleeding and MortalityAfter Lower Gastrointestinal Bleeding in Patients Taking Antiplatelets or Anticoagulants Time to Colonoscopy and Risk of Colorectal Cancer in Patients With Positive Results From Fecal Immunochemical Tests Efficacy of Live Attenuated Herpes Zoster Vaccine in Patients With Inflammatory Bowel Diseases Heterogeneity of Colorectal Cancer Risk Factors by Anatomical Subsite in 10 European Countries: A Multinational Cohort Study Barriers and Facilitators to Mediterranean Diet

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Issue Highlights - May 2019

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2019/05/01

Accuracy of Noninvasive Scoring Systems in Assessing Risk of Death and Liver-Related Endpoints in Patients With Nonalcoholic Fatty Liver Disease Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Have Functional Esophageal Disorders Numbers and Features of Patients With a Diagnosis of Celiac Disease Without Duodenal Biopsy, Based on a National Survey Clinical and Molecular Factors Associated With Histologic Response to Topical Steroids in Patients With

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Issue Highlights - April 2019

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2019/04/01

Progression of Barrett’s Esophagus to Malignancy Low-Dose Aspirin and Gastrointestinal Bleeding Functional Nausea and Vomiting Disorders in Adults Cost Effectiveness of Universal Screening for Hepatitis C Virus

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Issue Highlights - March 2019

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2019/03/01

Safety and Efficacy of Budesonide Oral Suspension Maintenance Therapy in Patients With Eosinophilic Esophagitis Safety and Acceptability of Esophageal Cytosponge Cell Collection Device in a Pooled Analysis of Data From Individual Patients Acceptability, Accuracy, and Safety of Disposable Transnasal Capsule Endoscopy for Barrett's Esophagus Screening Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe

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Issue Highlights - February 2019

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2019/02/01

Previous Use of Antithrombotic AgentsReduces Mortality in Patients WithHigh-risk Upper Gastrointestinal Bleeding The Association Between Mutations in BRAF andColorectal Cancer–Specific Survival Depends on Microsatellite Status andTumor Stage Patient-Reported Outcomes and Endoscopic Appearance of Ulcerative Colitis: A Systematic Review and Meta-Analysis

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Issue Highlights - January 2019

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2019/01/01

New data shed little light on if screening individuals at high-risk for pancreatic cancer is effective and cost-effective in the long term. Tofacitinib-induction therapy reduces symptoms within 3 days for patients with UC. Vedolizumab is effective for adult UC patients who are anti-tumor necrosis factor naïve. ESD is safer and more effective than esophagectomy for early-stage esophageal squamous cell carcinoma. New findings show that endoscopic ultrasound accurately distinguishes celiac

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Issue Highlights - December 2018

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2018/12/01

Some medications for IBD increase risk for herpes zoster. Nationwide study in Korea shows increase in risk of herpes zoster in patients with IBD, especially for those with ulcerative colitis. New study shows long-term benefits of achieving maintained virologic response in patients with HBV, even after development of decompensated cirrhosis. BMI is a significant predictor in discrepancy when assessing fibrosis in NAFLD with MRE vs. TE. New study shows that restarting DOACs within 30 days

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Issue Highlights - November 2018

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2018/11/01

Endoscopist-related factors, rather than biology, are more likely to account for interval cancers in the proximal colon. New data suggest that Crohn's patients have greater risk of high-risk HPV infection and thus may benefit from anal cancer screening. New study on the factors associated with response to placebo in IBD patients has implications for clinical trial design. Research finds an association between the grade of acute on chronic liver failure and response to terlipressin and albumin

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Issue Highlights - October 2018

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2018/10/01

New study further suggests an association between IBD disease activity and cardiovascular risk. Clinicians should consider screening for latent tuberculosis prior to the initiation of corticosteroids for IBD. Diet and gut microbiota play an important role in CRC development, with low-inflammatory diets showing benefits. Granulocyte colony stimulating factor with or without N-acetyl cysteine may be a safe and effective treatment for severe alcoholic hepatitis.

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Issue Highlights - September 2018

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2018/09/01

New study of registry data adds important data to the temporal trends of surgical risk in pediatric Crohn’s Pancreatic lesions with a greater growth rate have increased odds of exhibiting worrisome features The learning curve for POEM is longer in managing complex cases and avoiding risks than the learning curve for achieving technical proficiency No histologic benefit in modest alcohol use in NAFLD patients.

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Issue Highlights - August 2018

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2018/08/01

Two new clinical trials show differences in the comparative diagnostic yield of EUS-guided FNA and FNB for pancreatic solid masses Significantly variability exists in the burden of hospitalization across patients with chronic GI and liver diseases New scoring system helps identify patients at risk for esophageal adenocarcinoma Endoscopic balloon dilation plays a therapeutic role in treating Crohn’s patients

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Issue Highlights - July 2018

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2018/07/01

Meta-analysis looks at age, gender, smoking, and other risks associated with Barrett’s esophagus Cytopathologists have suboptimal interobserver agreement for EUS-FNA for diagnosis and staging of pancreatic cancer New research sheds light on the association between mucosal and transmural healing in Crohn’s patients IBS and chronic fatigue can persist after the Giardia infection

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