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PODCAST

The BioInsights Podcast

The BioInsights Podcast: discussing the challenges of translating novel biologics from bench to clinic to market.

science life sciences

All Episodes

33:47

Advancing nucleic acid therapeutics with circular RNA

The BioInsights Podcast ·

2025/10/27

In this podcast episode, Jokūbas Leikauskas, Editor, BioInsights, speaks to Trevor Hallam, who served as Chief Scientific Officer of Sail Biomedicines until July 2025. The interview, recorded in June 2025, explores advances in RNA therapeutics, particularly circular RNA (circRNA or eRNA) technologies, and how they may help overcome current limitations in delivery, durability, and specificity for applications such as CAR-T cell therapies and autoimmune disease treatment.

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15:29

Exploring advances in bioconjugation: nanozymes,...

The BioInsights Podcast ·

2025/10/01

Lauren Coyle (Commissioning Editor, Bioconjugation Insights) speaks to Vincent Rotello (Distinguished Professor of Chemistry, University of Massachusetts Amherst) about the advantages and limitations of different nanomaterial platforms, and emerging strategies such as tissue tropism and responsive nanozymes that could advance targeted therapeutic and diagnostic delivery.

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21:22

The promise of antibody-oligonucleotide conjugates...

The BioInsights Podcast ·

2025/08/27

Lauren Coyle, Launch Commissioning Editor, Bioconjugation Insights, speaks with Kerstin Hofer, Science and People Lead, Roche, about the evolving application of antibody-oligonucleotide conjugates in neurology. She highlights their design, delivery challenges across the blood–brain barrier, and potential to transform CNS diseases.

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19:49

From innovation to access: bridging gaps in...

The BioInsights Podcast ·

2025/07/18

Jokūbas Leikauskas, Editor, BioInsights, speaks to Rohin Iyer, Senior Director, Global Cell and Gene Therapy Operations, Marken, about addressing the complex logistics of cell and gene therapies through global infrastructure, precision, and advanced technologies. They also discuss evolving cold chain needs, regulatory and geopolitical challenges, and the need for scalability.

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12:53

Enhancing mRNA results through strategic RNA design...

The BioInsights Podcast ·

2025/03/27

In the last few years, mRNA has moved to the fore in the vaccine and cell and gene therapy fields, and as a result, its successful production for these downstream applications has never been more crucial. In this podcast episode, Róisin McGuigan, Editor, Nucleic Acid Insights, speaks to Ryan Lahr, Senior R&D Scientist, CELLSCRIPT, about design, production, and quality control of synthesized mRNA for translation in cells.

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19:09

For the many and the few: bringing ASO therapies to...

The BioInsights Podcast ·

2025/03/13

Roisin McGuigan, Commissioning Editor, Nucleic Acid Insights, speaks to Stanley Crooke, Chairman, Founder and CEO, n-Lorem, about his long career and pioneering role in the antisense oligonucleotide (ASO) space, how RNA-targeting therapies are set to enter the mainstream, and his latest focus: making personalized, free-for-life ASO therapies available to nano-rare patient populations.

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15:03

Exploring challenges, opportunities and...

The BioInsights Podcast ·

2025/02/19

Róisin McGuigan, Commissioning Editor, Nucleic Acid Insights, speaks to Ketaki Deshmukh, Senior Scientist, Novo Nordisk, about advanced characterization tools for LNPs, challenges in extrahepatic delivery, scalability issues, and the potential impact of AI and machine learning (ML) on future LNP development.

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15:38

Driving innovation in cell and gene therapy: the role...

The BioInsights Podcast ·

2025/01/27

Jokūbas Leikauskas, Editor, Cell & Gene Therapy Insights, speaks with OmniaBio Inc.’s Kenneth Harris, Chief Strategy Officer and Head of AI, Mitchel Sivilotti, President and CEO, and Anthony Rotunno, Senior Vice President and General Manager/Site Head, about the innovative advancements in cell and gene therapy, focusing on how AI, automation, and robotics are revolutionizing manufacturing processes by reducing costs, increasing production capacity, and ultimately, improving patient outcom...

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38:44

Spatial mapping: shaping the future of I-O...

The BioInsights Podcast ·

2024/12/06

Lauren Coyle, Commissioning Editor, Immuno-Oncology Insights, speaks with Banafshé Larijani, Director of the Centre for Therapeutic Innovation, University of Bath, about the development and application of a novel spatial mapping technology designed to improve cancer diagnostics and personalize treatment planning.

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28:08

Pioneering quality control in biomanufacturing of...

The BioInsights Podcast ·

2024/12/05

Lauren Coyle, Commissioning Editor, speaks with Dhruv Sareen, Executive Director at Cedars-Sinai Biomanufacturing Center, and Johnathan Rodriguez, Quality Control Manager at Cedars-Sinai Biomanufacturing Center, about the roles of in-process controls, method validation, risk management, and automation in biomanufacturing. They will highlight strategies to ensure product safety, consistency, and regulatory compliance for cell and gene therapy products.

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25:36

Preparing for tomorrow’s cell and gene therapies...

The BioInsights Podcast ·

2024/09/06

For the first time in history, cell and gene therapy products are reaching the market in waves rather than in one’s and two’s, creating unprecedented challenges for pharma/biotech and healthcare sector stakeholders alike. David McCall, Senior Editor, BioInsights, speaks to Eric Faulkner, President and Chief Strategist, Passage Health Associates, about the chequered history of market access in the advanced therapies field, and what lessons can be taken forward to ensure a successful and sustai...

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22:37

Insights into advanced therapies in the context of...

The BioInsights Podcast ·

2024/06/14

David McCall, Senior Editor, BioInsights, spoke to Lee Brown, Healthcare Sector Global Team Leader, Third Bridge Group, on Tuesday, February 6, 2024 to gain his insights into the fast-moving market landscape of advanced therapies. The discussion outlines key recent news and strategic moves from prominent pharma and biotech companies in the field, as well as the prospects for specific technologies such as CRISPR-based genome editing and next-generation CAR-T therapies.

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28:20

Fit for function: developing potency assays...

The BioInsights Podcast ·

2024/05/10

Translating the therapeutic promise of cell and gene therapies into clinical reality relies on robust potency assays. However, designing assays that accurately reflect the complex mechanisms of these therapies can feel like chasing a moving target. Here, Charlotte Barker, Editor, Cell & Gene Therapy Insights, speaks with Giorgio Zenere, CMC technical project lead in the Global QC Technology Innovation Team, Kite Pharma, and Dirk Windgassen, Director of Analytical Development, Miltenyi

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23:36

Gene therapy is having a monumental year: how can the...

The BioInsights Podcast ·

2024/04/04

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43:52

A deep dive in to generative AI applications in I-O

The BioInsights Podcast ·

2024/03/18

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14:57

Developing novel radioimmunotherapy combinations for...

The BioInsights Podcast ·

2024/03/12

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45:24

Focusing on the fundamentals: what do and don’t we...

The BioInsights Podcast ·

2024/03/11

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20:23

Navigating genomics and transcriptomics in the...

The BioInsights Podcast ·

2024/03/01

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23:38

Avian influenza and the risk of pandemic

The BioInsights Podcast ·

2024/02/27

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17:05

Exploring the landscape of novel targets & pathways...

The BioInsights Podcast ·

2023/12/04

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57 results

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