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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

00:12:08

What If You Stop Eating For 72 Hours? : 1375

The Human Upgrade: Biohacking for Longevity &... ·

2025/12/07

Dave Asprey breaks down what really happens during a 72-hour fast, showing how deep cellular repair, autophagy, and mitochondrial rejuvenation activate only in the later stages of fasting and how to prepare, fast, and refeed safely for the strongest anti-aging results.

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00:57:18

The Real Reason Your Face Is Aging So Fast : 1376

The Human Upgrade: Biohacking for Longevity &... ·

2025/12/05

Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen mitochondria, improve detox capacity, and upgrade skin density with pharmaceutical grade delivery systems that outperform conventional skincare. You learn why most topical antioxidants never reach their intended targets, how intracellular copper changes longevity pathways, why

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01:01:16

Feel 70 Percent Better… With Grapes? | Biohacking...

The Human Upgrade: Biohacking for Longevity &... ·

2025/12/04

If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain

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00:55:57

The Machine That Flicks on Your Brain in 30 Seconds |...

The Human Upgrade: Biohacking for Longevity &... ·

2025/12/02

This episode explores how Raffaele Gianfrancesco uses vibroacoustics, flickering light, and harmonic frequency technology to rapidly shift brain states, release stored trauma, and create deep coherence in the mind and body.

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00:22:36

How I Lost 100 Pounds By Drinking Butter Coffee : 1371

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/30

This episode tells the true story of how a burned out Silicon Valley millionaire discovered a simple Tibetan drink that transformed his energy, rewrote the science of fat and metabolism, and sparked a global movement that changed how the world eats and performs.

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00:45:05

Get a Full Body Workout in 10 Minutes by Doing...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/28

This episode reveals how whole body vibration unlocks rapid circulation, lymphatic drainage, balance, and nitric oxide activation, giving you many of the benefits of a full workout while you stand still.

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01:16:15

How to Stop Brain Fog After Anesthesia | Biohacker...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/27

In this episode, Dave Asprey and Dr. Cameron Chesnut reveal how cutting edge anesthesia protocols, regenerative fat transfer, metabolic prep, peptides, ketones, hyperbarics, and non opioid pain strategies can transform any surgical procedure into a safer, faster healing, brain protected experience with dramatically improved long term results.

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00:51:10

Why Breathwork Feels Like a Euphoric Drug | Biohacker...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/25

Breathwork is one of the most powerful tools in biohacking, yet most people only experience the surface level techniques. When you use it the right way, breathwork can upgrade your brain, strengthen your nervous system, improve sleep, and open awareness states that amplify longevity and human performance.This episode features Ishan Shivanand, a globally celebrated yogic scholar, mental health researcher, and bestselling author who was raised in the monasteries of India under Mahasiddha

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00:14:22

Dead Water Is Making You Sick! (Biohacking Bonus...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/24

This episode reveals why “dead water” leaves you foggy and dehydrated, breaks down what your body actually needs to stay balanced, and shows simple hydration upgrades that improve energy, focus, and cellular performance.

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00:09:45

10-Minute Biohacking News Update : 1367

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/21

A fast moving roundup of the week’s biggest breakthroughs in longevity and biohacking, from nano CBD pain relief and calorie restriction aging data to AI guided Alzheimer’s surgery, engineered gut microbes, and the rise of Klotho as a next generation anti aging therapy.

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00:35:37

The Methylene Blue Episode | Solo Biohacking...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/20

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions.Watch this episode on YouTube for the

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00:56:04

The Tiny Implant Replacing Life-Changing Drugs |...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/18

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulation could redefine human performance, longevity, and brain optimization. You will learn how electricity, neurotransmitters, and targeted neural pathways can replace drugs, control inflammation, and help you hack the vagus nerve with precision instead of guesswork.Watch this episode on YouTube for the full video

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00:14:50

The Boring Secret Behind Celebrities Who Don’t Age :...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/16

This episode reveals how lobsters, telomeres, and a little-known enzyme point to a surprising anti-aging pathway you can activate in just ten minutes a day through simple, evidence-backed practices that help slow cellular aging.

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00:10:00

Biohacking News Weekly Update : 1363

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/14

This week's biohacking roundup covers five major breakthroughs: cocoa extract reducing cardiovascular deaths by 27%, FDA-cleared AI stethoscopes for home health monitoring, the explosive rise of beef organ supplements among women, spirulina's renewed spotlight for longevity and collagen support, and new Senate legislation to protect health data from wearables and wellness apps.

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01:03:49

How to Build Muscle WITHOUT Lifting! Biohacker...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/13

Host Dave Asprey talks with Dr. Sten Stray-Gundersen to reveal how blood flow restriction and intermittent hypoxia training unlock faster strength, hormone, and longevity gains by optimizing oxygen use, vascular health, and mitochondrial performance with minimal effort.

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00:39:28

Why Motivation DOESN’T Work | Mental Biohacks : 1361

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/11

True transformationdoesn’tcome from motivation. It comes from rewiring your mind, reshaping your beliefs, and mastering yourperceptionof reality. This episode reveals how to stop chasing short bursts of inspiration and start creating sustainable change in your thoughts, energy, and biology.You’lllearn how belief, emotion, and neuroplasticity shape human performance, longevity, and resilience—and how to reprogram them for lasting results.Watch this episode on YouTube for the full video

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00:09:22

New Japanese Walking Hack Burns More Fat Than 10,000...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/09

Dave Asprey reveals a powerful Japanese walking method that burns fat faster than 10,000 steps, lowers stress, boosts mitochondrial health, and transforms metabolism in just 15–30 minutes a day.

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00:11:39

Biohacking News Weekly Update : 1359

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/07

Dave Asprey breaks down six new breakthroughs in biohacking and health tech—from melatonin’s hidden heart risks to mitochondrial immune upgrades, AI that decodes cells, and a first-ever blood test for chronic fatigue—giving you the data you need to live longer, think faster, and perform at your peak.

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01:00:08

The Strange Science Behind Tylenol and Heartbreak |...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/06

Painisn’tjust in yourbody,it’sin your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Daniel Amen to reveal how emotional and physical pain share the same neural circuits and how you can rewire them for relief, resilience, and longevity.You’lllearn practical tools to break the “doom loop” of pain, restore neuroplasticity, and retrain your brain for calm, healing, and high performance. This isessentiallistening for anyone ready to stop managing pain and start

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00:37:16

The New SCIENCE of Energy Healing | Biohacking...

The Human Upgrade: Biohacking for Longevity &... ·

2025/11/04

Your body does not just run on food or supplements. It runs on energy and information. This episode reveals how to harness that energy for faster recovery, stronger mitochondria, and better emotional resilience. You will learn how energy fields, frequency, and information medicine are reshaping the science of human performance, longevity, and anti-aging.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHostDave Aspreysits down withHarry

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