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PODCAST

Decoding Health

Dr. Urban A. Kiernan

Step into the world of Decoding Health, where Dr. Urban A. Kiernan and renowned experts delve into a myriad of fields, unraveling the complexities of science and its practical applications in our daily health. This show is committed to illuminating topics ranging from personal health and wellness to cutting-edge biopharmaceutical advancements and beyond.Join us each week for an enlightening journey through the realms of science and discover the incredible tools that can enhance your everyday

health & fitness medicine

All Episodes

11:29

South Park Was Right: Flip The Food Pyramid (But...

Decoding Health ·

2026/03/05

Send a textIn this episode of Decoding Health, Dr. Urban reacts to a viral cultural moment—South Park’s “flip the food pyramid” satire—and uses it to unpack what a real shift in U.S. nutrition guidance would mean for metabolic health. He breaks down the core changes being celebrated: higher prioritization of protein and fat, reduced emphasis on grains and refined carbohydrates, and updated protein targets (including the renewed acceptance of red meat as a viable protein source). The takeaway is

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64:25

How To Build Confident Kids Without The “Pro Athlete”...

Decoding Health ·

2026/03/02

Send a textIn this Decoding Health episode, Dr. Urban A. Kiernan sits down with Alex Weisman, founder of Quantum Human Performance and a KidStrong owner/operator in the Phoenix market, for a wide-ranging conversation on what children’s health actually requires in 2026. They break down KidStrong’s science-based model built around physical development, cognitive training, and character-building, and why it matters in an era of screens, shrinking PE programs, and rising metabolic risk in kids. Alex

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20:24

The Rise of Insulin Resistance

Decoding Health ·

2026/02/26

Send a textIn this Decoding Health hot-seat episode, Dr. Urban A. Kiernan breaks down the real “upstream” story behind type 2 diabetes—and why the most dangerous phase often happens long before your labs ever flag you as “diabetic.” He explains the progression from insulin resistance → so-called “pre-diabetes” → type 2 diabetes, why he considers the “pre-diabetes” label a false comfort zone, and how modern life factors like endocrine disruptors, chronic stress, diet, and low movement quietly stack

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46:18

Skinny Fat Is Real: How To Read A DEXA Scan For True...

Decoding Health ·

2026/02/23

Send a textIn this Decoding Health episode, Dr. Urban A. Kiernan sits down with returning guest Dr. Micah Olson (pediatric endocrinologist turned longevity physician and founder of Valley HealthSpan in Phoenix) to unpack what DEXA scans can actually reveal about true health—not just aesthetics. They break down how DEXA goes beyond bone density to deliver actionable body-composition metrics like lean mass, body fat percentage, and—most importantly—visceral adipose tissue, the internal fat linked to

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17:22

Not All Body Fat Is The Same

Decoding Health ·

2026/02/19

Send a textIn this episode of Decoding Health, Dr. Urban breaks down one of the most misunderstood—and most dangerous—topics in modern health: visceral fat. While most people focus on the fat they can see or pinch, Dr. Urban explains why peripheral fat is largely aesthetic, while visceral (also called ectopic) fat is metabolically toxic. This internal fat infiltrates organs like the liver, pancreas, and muscle tissue, impairing function at both the organ and cellular level. The discussion clarifies

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63:06

From Big T To Fitness Phenom with Tony Drake

Decoding Health ·

2026/02/16

Send a textIn this episode of Decoding Health, Dr. Urban A. Kiernan sits down with Tony Drake—lifestyle transformation coach, former WWF wrestler, and the man who lost 130 pounds and dropped from ~40% body fat to ~6%—to unpack what actually drives sustainable fat loss and lasting metabolic health. Tony shares the pivotal mindset shift that forced “Big T” to die, how consistent training and nutrition rewired his identity, and how that transformation opened doors to wrestling with WWE/WWF and touring

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11:13

Urolithin A Explained: The Mitochondrial Upgrade...

Decoding Health ·

2026/02/12

Send a textIn this episode of the Decoding Health, Dr. Urban Kiernan breaks down the science behind Urolithin A, a gut-derived compound gaining attention for its role in mitochondrial health, muscle performance, and metabolic function.The conversation explains what Urolithin A actually is (and what it isn’t), how it’s produced through the gut microbiome, and why it’s fundamentally different from peptides. Dr. Urban walks through the concept of mitophagy—the cellular process that clears damaged

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59:41

Insulin Resistance & Prediabetes: Metabolic Reset...

Decoding Health ·

2026/02/09

Send us a textDr. Kaitlin Castillo pulls back the curtain on why so many people can look healthy on the outside while quietly living in a metabolic “danger zone” underneath the surface. Using real-world clinical context, she breaks down what processed, packaged eating does to blood sugar regulation, why insulin resistance can progress for years before patients are clearly warned, and what “good doctor” communication should look like when labs start trending in the wrong direction.The conversation

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13:06

GHK-Cu Explained: The Science Behind Copper Peptides,...

Decoding Health ·

2026/02/05

Send us a textGHK-Cu (copper peptide) has surged in popularity across regenerative medicine, aesthetics, and biohacking—but what does the science actually say? In this episode of Decoding Health, Dr. Urban breaks down the real physiology behind GHK-Cu, a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. You’ll learn how this peptide supports wound healing, collagen remodeling, tissue regeneration, and why it’s increasingly used for skin rejuvenation and hair

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65:33

Metabolic Syndrome: The Real Heart Attack Warning...

Decoding Health ·

2026/02/02

Send us a textRonald M. Krauss joins the show for a practical, myth-busting deep dive into cardiometabolic risk, lipidology, and why the LDL conversation is often framed in the wrong direction. Building on his long-standing advisory-level relationship with Dr. Urban and his “disruptor” approach to improving outcomes, Dr. Krauss clarifies the critical difference between LDL and LDL cholesterol, uses a memorable “bus cholesterol” analogy to explain particle number vs. cholesterol content, and ties the

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11:58

Why Natural GLP-1 Disappears So Fast: DPP-4,...

Decoding Health ·

2026/01/29

Send us a textGLP-1 is a gut-derived hormone designed to signal the pancreas to produce insulin—but in its natural form, it’s notoriously short-lived. In this Decoding Health segment, we break down why endogenous GLP-1 has an ultra-short half-life (about three minutes), and how the enzyme DPP-4 rapidly “clips” incretin hormones by targeting specific amino acids near the N-terminus—effectively destroying the signal before it can last.You’ll learn how GLP-1 receptor agonist drugs were engineered to

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58:32

How To Fix The Food System When Policy Won’t With Dr....

Decoding Health ·

2026/01/26

Send us a textDr. Robert H. Lustig joins the show to break down why today’s metabolic health crisis is not a personal failure problem, but an environment problem, and how the power structure shaping food, policy, and public health has shifted in ways most people have not tracked. From “poisonous calories” and ultra-processed food to microplastics, reactive species, and artificial sweeteners, Dr. Lustig connects the biochemical dots to the brain, explaining how the amygdala functions like an

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11:45

New Science, New Guidance: Rethinking Hepatitis B...

Decoding Health ·

2026/01/22

Send us a textIn this episode of Decoding Health, we examine a recent shift in CDC guidance regarding hepatitis B vaccination recommendations for newborns. Long criticized for lagging behind evolving science, the CDC has now revised its position after reviewing updated risk-benefit data presented during a publicly broadcast panel discussion.Sparked by the birth of the host’s second grandchild, the conversation breaks down how hepatitis B is transmitted, why infection risk for infants born to

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48:51

Protein, Stress, and the Truth About Sustainable...

Decoding Health ·

2026/01/19

Send us a textThis episode featuring Dana Swope explores the intersection of nutrition, movement, stress, and metabolic health through an open, thought-provoking conversation. The discussion highlights how prioritizing protein and whole foods can reduce overall calorie needs while significantly increasing satiety, signaling a meaningful shift in how we approach sustainable nutrition. The episode also addresses the critical role stress plays in weight loss, reinforcing that meaningful fat loss is

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12:39

The Amylase Test: What Your Digestion Is Trying to...

Decoding Health ·

2026/01/15

Send us a textThis episode breaks down the Amylase test and its critical role in digestion, metabolic health, and personalized nutrition. The conversation explores how amylase activity impacts carbohydrate processing, energy levels, and blood sugar response, highlighting why a one-size-fits-all approach to diet does not work. Listeners learn how simple indicators like taste response and timing windows can reveal enzyme efficiency, when to pull back on certain carbs, and what low amylase activity may

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57:55

True Fasting vs. Intermittent Eating: How Insulin &...

Decoding Health ·

2026/01/12

Send us a textIn this episode of Decoding Health, Dr. Urban A. Kiernan is joined by Dr. Don Clum for an in-depth, science-driven discussion on fasting, insulin regulation, and metabolic health—cutting through popular misconceptions to explain what fasting actually is and how it impacts the body.The conversation begins with how early insulin research led to modern fasting protocols and clarifies the difference between time-restricted eating, intermittent fasting, and true fasting. Dr. Clum explains

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14:34

What The Heck is an Adjuvant?

Decoding Health ·

2026/01/08

Send us a textIn this episode of Decoding Health, Dr. Urban A. Kiernan breaks down the science behind vaccine adjuvants—what they are, why they are used, and how they influence immune responses. Drawing from his experience in biotechnology and pharmaceutical research, he explains how adjuvants enhance antibody production and increase the body’s overall biological workload.We explore commonly used compounds such as aluminum salts and newer immune-stimulating agents, while examining concerns around

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65:21

From Skinny Fat to Bariatric Surgery: What Obesity...

Decoding Health ·

2026/01/05

Send us a textIn this episode, Dr. Evan Nadler challenges some of the most common misconceptions surrounding childhood and adolescent obesity—starting with the idea that it’s simply a result of poor diet or lack of willpower. Drawing on more than two decades of clinical, surgical, and research experience, he explains why obesity is a chronic disease, why BMI is an unreliable diagnostic tool, and how true risk should be assessed based on physical and mental health impact.The conversation explores the

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16:48

The Real Science Behind Vyleesi: Arousal, Appetite,...

Decoding Health ·

2026/01/01

Send us a textWhat are the real side effects of Vyleesi—and how do they compare to Viagra?In this follow-up conversation, Dr. Urban A. Kiernan breaks down what Vyleesi (also known as PT-141) is, how it works, and why it’s being discussed as a modern option for women experiencing low sexual desire, arousal challenges, or vaginal dryness (when prescribed for specific diagnoses). You’ll learn how Vyleesi’s mechanism differs from Viagra’s nitric-oxide-driven vasodilation, why Vyleesi is delivered via an

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71:58

Food, Stress, And Inflammation: Why Your Body Is...

Decoding Health ·

2025/12/29

Send us a textMichal Ofer shares the personal turning point that reshaped her entire approach to health—going from taking 30 pills a day at 35 to stepping away from medications and focusing on root-cause inputs that actually move the needle. She breaks down how diet directly affects stress tolerance, which foods tend to be most inflammatory, and why food quality can feel dramatically different across countries (and even compared to earlier eras in the U.S.). The conversation also compares healthcare

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171 results

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