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ATCC"s Podcast: Behind the Biology

ATCC

ATCC: Behind the Biology Podcast

science life sciences

All Episodes

21:45

Episode 45: Where Standards Meet the Next Frontier

ATCC"s Podcast: Behind the Biology ·

2026/03/31

In this episode, Frank Simione explores the future of ATCC. Frank highlights the transformation initiated by Dr Raymond Cypess and continued by Dr Ruth Cheng, which required ATCC to operate more like a business to achieve financial stability. Frank suggested that ATCC's future lies in vertical growth through revolutionary advancements and major technological innovations, similar to venture capital strategies, to ensure sustainable growth. They acknowledged that while contracts, outbreaks, and

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23:31

Episode 44: How ATCC Became Mission‑Critical

ATCC"s Podcast: Behind the Biology ·

2026/03/24

In this episode, David Yarmosh welcomes Frank Simione back to discuss ATCC's evolution from relying on government subsidies to securing government contracts, a shift initiated in the 1990s under Dr. Raymond Cypess's leadership. The discussion also covers ATCC's unique market position, the importance of preserving materials like the Zika virus, and ATCC's role as a patent depository, starting in 1949 and becoming the first International Depository Authority in 1981.

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23:44

Episode 43: From Museum Drawers to Global Standards

ATCC"s Podcast: Behind the Biology ·

2026/03/17

In this episode, Frank Simione, often referred to as the ATCC historian, discusses the rich history of the organization. Frank, who boasts a 42-year tenure with the organization, shares insights from his time as the Director of Standards, overseeing the development and recognition of standards by ANSI. He also touches on the role of the Biological Standards Institute and ATCC's mission to provide standardized biological materials, such as the E. coli strain used in antibiotic susceptibility testing

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23:56

Episode 42: Future‑Ready Science- The Vision for...

ATCC"s Podcast: Behind the Biology ·

2026/02/24

Join in, to hear Dr. Ruth Cheng, CEO share her vision for ATCC’s future, emphasizing the need for organizational agility, calculated risk-taking, and alignment with the pace of scientific progress. She highlights recent initiatives like the partnership with Align to Innovate to develop digital data reference standards and outlines plans to expand ATCC’s global footprint. Dr. Cheng discusses investments in cutting-edge technologies such as microphysiological systems, single-cell sequencing, and

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16:11

Episode 41: Tough Calls & Transformative Science- A...

ATCC"s Podcast: Behind the Biology ·

2026/02/17

Listen in to hear Dr. Ruth Cheng dive into the pivotal career moments that shaped her leadership style and strategic mindset. She recounts leading a therapeutic delivery project at Boston Scientific that she ultimately chose to terminate—an experience that taught her the value of recognizing failure early and reallocating resources wisely. At Smith & Nephew, she embraced a high-stakes strategic planning role without prior experience, relying on mentorship and collaboration. Dr. Cheng also

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29:37

Episode 40: Leading With a Scientist’s Mind-...

ATCC"s Podcast: Behind the Biology ·

2026/02/10

Tune in to hear Ruth Cheng, CEO of ATCC, reflect on her personal and professional journey during the organization’s centennial year. From a childhood fascination with science sparked by a high school teacher to leadership roles in biotech startups, Ruth shares how her identity as a scientist continues to shape her leadership. She discusses the importance of innovation, adaptability, and diverse perspectives in STEM leadership, and reaffirms ATCC’s mission to support scientific discovery through

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23:54

Episode 39: Sterile, Strategic, and Bold-...

ATCC"s Podcast: Behind the Biology ·

2025/10/30

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19:43

Episode 38: Global Vision, Local Impact- A Journey to...

ATCC"s Podcast: Behind the Biology ·

2025/10/30

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30:37

Episode 37: Curiosity, Crisis, and the Call to Lead

ATCC"s Podcast: Behind the Biology ·

2025/10/29

In this episode, Becky Bradford, a senior vice president at ATCC, shares her inspiring journey from a science-loving child in Oklahoma to a leader in biomanufacturing. With over twenty years of experience, she reflects on her early career during the human genome sequencing boom and her diverse background in various biology fields. Becky emphasizes the importance of operational knowledge, quality materials, and educational opportunities in advancing her career. She highlights ATCC's commitment to

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24:02

Episode 33: Fueling the Future- BAT, Bile Acids, and...

ATCC"s Podcast: Behind the Biology ·

2025/07/22

In this episode, Dr. Aaron Cypess discusses the future of brown adipose tissue (BAT) and white adipose tissue (WAT) research at the NIDDK, focusing on three pillars: integrative physiology, noninvasive imaging, and clinical trials. First, there's integrative physiology, where scientists use cell lines to dig into how fat cells work, how they burn energy, and how they respond to obesity treatments. Then there's noninvasive imaging—think PET-CT and MRI—which helps researchers actually see where fat is

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20:42

Episode 32: BAT Breakthroughs and the Bridge from...

ATCC"s Podcast: Behind the Biology ·

2025/07/15

In this episode, Dr. Aaron Cypess discusses two pivotal moments that led him to change his approach to research. Initially planning to major in biology, he was encouraged to study chemistry, which provided a strong foundation in precision and quantitative analysis. During his endocrinology fellowship, Dr. Cypess shifted his focus to clinically relevant research, leading to his entry into the Clinical Investigator Training Program. This program allowed him to leverage his dual MD and PhD training to

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21:37

Episode 31: Brown and White Adipocytes- A Hot Topic...

ATCC"s Podcast: Behind the Biology ·

2025/07/08

In this conversation, Dr. Aaron Cypess discusses his research on brown adipose tissue (BAT), an organ that burns fat to generate heat. Initially thought to be present only in small mammals and young children, functional BAT was discovered in adult humans in 2009, spurring global research into its potential for treating obesity and metabolic diseases. Dr. Cypess explains the differences between BAT and white adipose tissue (WAT), and how BAT communicates with other tissues through hormones. Dr

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21:48

Episode 30: Methylation, Metadata, and More

ATCC"s Podcast: Behind the Biology ·

2025/06/24

In this episode, David Yarmosh and Briana Benton discuss the future of the ATCC Genome Portal, focusing on upcoming data types and platform enhancements. Benton reveals that by the end of 2025, researchers will gain access to methylation data for the bacteriology collection with future plans to annotate virology genomes, integrate antimicrobial susceptibility data, and enable advanced search features such as taxonomy browsing and gene-based queries. As the portal evolves into a dynamic “digital

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20:17

Episode 29: From IRAD to Impact

ATCC"s Podcast: Behind the Biology ·

2025/06/17

In this episode, David Yarmosh and Briana Benton revisit the origins and evolution of the ATCC Genome Portal, tracing its journey from an ambitious research concept in 2017 to a groundbreaking resource for high-quality, traceable genomic data. Benton shares how early internal research proposals—including her push for long-read sequencing and Dr. Marco Riojas’ vision for sequencing ATCC’s collection—laid the foundation for the portal. Their work, along with challenges in microbiome research where

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22:41

Episode 28: Ground Truth Genomics

ATCC"s Podcast: Behind the Biology ·

2025/06/10

In this episode, Briana Benton presents the ATCC Genome Portal, which was launched in 2019 to offer researchers high-quality, traceable genome data directly associated with physical materials in the ATCC collection. Benton explained that each genome published on the portal is produced entirely in-house, adhering to ISO 9001 standards from strain cultivation to final genome assembly. With over 5,500 genomes currently available and new additions made quarterly, the portal aims to eventually encompass

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24:37

Episode 27: MicroQuant™- Modernizing Quality Control...

ATCC"s Podcast: Behind the Biology ·

2025/02/04

In this episode, Dr. Nilay Chakraborty discusses the newly launched MicroQuant portfolio by ATCC, which consists of quantitated microbial reference materials designed to simplify quality control testing. These materials are essential for ensuring the safety and efficacy of products across various industries, including food, cosmetics, and pharmaceuticals. The portfolio includes 12 products that meet stringent regulatory requirements, focusing on ease of use and delivering consistent results in terms

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21:42

Episode 26: ThawReady™- Transforming Cryopreservation...

ATCC"s Podcast: Behind the Biology ·

2025/01/28

Dr. Chakraborty continues his discussion on cryobiology, focusing on the innovative ThawReady™ Assay Ready Cells that his group developed. He explains that traditional cryopreservation methods cause cellular injuries that manifest when cells are thawed, leading to delayed functionality. ThawReady™ Assay Ready Cells are designed to minimize these injuries, allowing immediate use after thawing and reducing the time and effort required for cell culture. Dr. Chakraborty goes on to discuss the strategic

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21:01

Episode 25: Freezing the Future- Revolutionizing...

ATCC"s Podcast: Behind the Biology ·

2025/01/21

In this episode Dr. Nilay Chakraborty, head of the Cryobiology Research and Development Department at ATCC, explains his group's focus on creating innovative technologies and products involving ATCC's organisms and cell lines. Dr. Chakraborty stresses the overall aim to improve the delivery and format of these materials to better serve customers. He then discusses the challenges of managing ATCC's extensive catalog and the importance of cryopreservation in maintaining the bioactivity of biological

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22:25

Episode 24: The Convergence of Frontiers

ATCC"s Podcast: Behind the Biology ·

2024/10/01

Join in, to hear Dr Jesse Boehm discuss the convergence of advancements that are making precision medicine more effective for a larger percentage of patients. He touches on how access to molecular profiling has become more widespread and affordable, allowing more patients to get detailed molecular information about their tumors. Dr. Boehm then mentions how new types of chemistry and drug development are making it possible to target a wider range of cancer proteins. He goes on to describe how

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21:53

Episode 23: The Balance Between Collaboration and...

ATCC"s Podcast: Behind the Biology ·

2024/09/24

In this episode, Dr Jesse Boehm relates his inspiring journey into the world of translational research. Dr Boehm focuses on how his laboratory engineered solutions to complex biological problems, particularly cancer. He stresses the importance of working alongside cancer patients, sharing a very personal story and the impact it had on his perspective. Thanks to this perspective, Dr. Boehm encourages cancer scientists to consider urgency and patient impact of their research.

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ATCC"s Podcast: Behind the Biology

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