x

75% of people globally want unbiased news (Pew Research) but are concerned they're not getting that.

Get balanced coverage with Symby. See how stories are covered across diverse outlets and spot when one side covers a story the other skips.

PODCAST

In Silico Trials, Real Impacts!

UK CEiRSI | InSilicoUK

𝗜𝗻 𝗦𝗶𝗹𝗶𝗰𝗼 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗥𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻: 𝗨𝗞 𝗖𝗘𝗶𝗥𝗦𝗜’𝘀 𝗢𝗳𝗳𝗶𝗰𝗶𝗮𝗹 𝗣𝗼𝗱𝗰𝗮𝘀𝘁 on 𝗩𝗶𝗿𝘁𝘂𝗮𝗹 𝗖𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗧𝗿𝗶𝗮𝗹𝘀 & 𝗛𝗲𝗮𝗹𝘁𝗵𝗰𝗮𝗿𝗲 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻 Welcome to the official podcast of the 𝗨𝗞 𝗖𝗲𝗻𝘁𝗿𝗲 𝗼𝗳 𝗘𝘅𝗰𝗲𝗹𝗹𝗲𝗻𝗰𝗲 𝗼𝗻 𝗜𝗻 𝗦𝗶𝗹𝗶𝗰𝗼 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗼𝗿𝘆 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗮𝗻𝗱 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻 (𝗨𝗞 𝗖𝗘𝗶𝗥𝗦𝗜) and the 𝗜𝗻𝗦𝗶𝗹𝗶𝗰𝗼𝗨𝗞 𝗣𝗿𝗼 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻 𝗥𝗲𝗴𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗡𝗲𝘁𝘄𝗼𝗿𝗸. Discover how

science life sciences

All Episodes

28:26

Digital Twins & Virtual Patients: Revolutionising...

In Silico Trials, Real Impacts! ·

2025/06/30

Join us for an eye-opening exploration of how virtual patient data is revolutionising paediatric clinical trials. In our upcoming episode, we delve into groundbreaking research that addresses one of healthcare's most pressing challenges: the power crisis plaguing paediatric randomised controlled trials.Discover how digital twins, synthetic patient data, and in silico trials are offering unprecedented solutions to reduce children's exposure to unproven therapies whilst accelerating drug approvals

en

22:03

Beyond the Scalpel: How Computer Models Are Rewriting...

In Silico Trials, Real Impacts! ·

2025/06/23

This episode explores groundbreaking research from Boston Children's Hospital and Harvard Medical School that demonstrates how multiphysiologic state computational fluid dynamics (CFD) modelling is transforming surgical planning for children with complex congenital heart conditions.We delve into the innovative 3D virtual surgery workflow developed for patients with single ventricle physiology and interrupted inferior vena cava - a particularly challenging combination that historically carries high

en

17:17

Future-Proofing the UK Life Sciences Sector

In Silico Trials, Real Impacts! ·

2025/06/16

Are you prepared for the seismic shift transforming UK life sciences careers? This latest "In Silico Trials, Real Impacts!" episode reveals how AI and in silico technologies are creating unprecedented employment opportunities across health tech sectors. Discover the essential skills driving this revolution, from computational biology to digital therapeutics, and why lifelong learning has become non-negotiable. We examine the geographical spread of emerging roles and explore how international talent

en

32:52

Exploring the Limitations and Potentials of RCTs:...

In Silico Trials, Real Impacts! ·

2025/06/09

Are Randomised Controlled Trials (RCTs) always the definitive 'gold standard' in research? In the latest episode of In Silico Trials, Real Impacts!, we explore the nuanced landscape of RCTs, questioning their universal applicability and examining the complexities they often obscure. While RCTs are celebrated for their rigour, this discussion delves into their limitations, particularly when findings are applied across diverse contexts.Drawing on seminal work by Deaton and Cartwright (2018), this

en

27:59

Simpler or Complex: Rethinking Occam's Razor in...

In Silico Trials, Real Impacts! ·

2025/06/02

Is simplicity always the smartest choice in science? Or could complexity be the key to groundbreaking discoveries? This episode explores the evolving role of simplicity and complexity in scientific modelling, questioning the age-old principle of Occam's razor in light of modern advancements: Plurality should not be posited without necessity. Discover how digital approaches, from computational modelling to simulated clinical trials, are reshaping medical product development, making healthcare safer,

en

15:53

Evaluating Continuous Glucose Monitoring Sensors with...

In Silico Trials, Real Impacts! ·

2025/05/25

Could computer simulations redefine diabetes care? In this episode, we focus on a real medical product and the role of in silico trials in the transition from the Medtronic Guardian Sensor 3 to the Guardian 4 sensor, central to the Medtronic 780G pump system, which aims to simplify diabetes management by eliminating the need for fingerstick calibrations. Discover how computer simulations, clinical studies, and real-world data converge to evaluate this significant shift, revealing slight shifts in

en

16:40

Unveiling Evidence-Based Medicine Plus and...

In Silico Trials, Real Impacts! ·

2025/05/19

What is Evidence-Based Medicine Plus? This podcast episode explores the transformative power of computational modelling and simulated clinical trials in medical innovation. Discover the significance of evidence-based medicine (EBM) and evidential pluralism, emphasising the role of mechanistic evidence alongside traditional studies. Join us as we delve into compelling examples like mobile phone radiation and ACE inhibitors, highlighting how these insights enhance the external validity of treatments

en

19:12

What Underpins Model Credibility? Three Philosophical...

In Silico Trials, Real Impacts! ·

2025/05/12

How do philosophers of science think about model evaluation? Dive deep into the crucial process of model evaluation, a fundamental step in digital science that determines the effectiveness and precision of computational models.This episode explores three primary perspectives on model quality: the mirror view, relevant similarity, and fitness for purpose. Learn about the complexities and challenges involved in evaluating models, from data limitations to the intricate balance between accuracy and

en

20:23

Exploring Digital Twins: The Philosophy Behind...

In Silico Trials, Real Impacts! ·

2025/05/05

Have you ever wondered what makes a digital twin truly "twin-like" and not just another computer model? This fascinating question lies at the heart of modern healthcare innovation, where virtual copies of real-world systems are revolutionising how we approach medical research and patient care. Our latest episode delves into groundbreaking research that examines the philosophical underpinnings of digital twins, exploring what sets them apart from conventional computational models.We unpack how

en

25:14

Cracking the Code: Unveiling the Trustworthy World of...

In Silico Trials, Real Impacts! ·

2025/04/28

Are computational models ready to replace traditional clinical trials? This episode delves into the fascinating world of in silico trials and their growing role in regulatory evaluation of biomedical products. We explore a methodological framework based on the ASME VV-40-2018 standard that establishes credibility through verification, validation, and uncertainty quantification. From defining contextual use to conducting thorough risk analysis, we examine how these principles apply across

en

15:47

Revolutionising Healthcare: The Power of Synthetic Data

In Silico Trials, Real Impacts! ·

2025/04/21

Is the healthcare sector prepared to harness synthetic data's transformative potential whilst navigating its hidden pitfalls? This thought-provoking episode delves into the murky waters of synthetic data governance in medical research, examining how generative AI is reshaping our approach to patient information. As algorithms increasingly create convincing facsimiles of real clinical data, we explore the tantalising benefits—enhanced privacy protection, expanded research capabilities, and

en

22:57

How Can We Trust Computational Models in Healthcare?...

In Silico Trials, Real Impacts! ·

2025/04/14

Are you curious about how computer simulations are changing the way we evaluate medical devices? In this episode, we delve into the fascinating world of in silico clinical trials (ISCTs), a cutting-edge approach that uses computational models to assess the safety and effectiveness of medical interventions. We explore a recent paper that highlights the unique challenges of ensuring the credibility of ISCT results. The authors present a comprehensive workflow for assessing this credibility, drawing on

en

22:53

How Can We Trust Computational Models in Healthcare?...

In Silico Trials, Real Impacts! ·

2025/04/14

Are we ready to replace human clinical trials with computer simulations? This provocative question sits at the heart of emerging in silico clinical trial (ISCT) methodologies for medical devices. As development costs soar and ethical considerations mount, computational models offer a tantalising alternative—but only if we can establish their credibility.This episode explores a rigorous framework that could transform how we validate medical devices. Moving beyond traditional approaches, we'll

en

13:41

Probability & Patients: The Stochastic Science Behind...

In Silico Trials, Real Impacts! ·

2025/04/07

𝗪𝗵𝗮𝘁 𝗶𝗳 𝘁𝗵𝗲 𝗻𝗲𝘅𝘁 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝘁𝗿𝗶𝗮𝗹 𝗯𝗿𝗲𝗮𝗸𝘁𝗵𝗿𝗼𝘂𝗴𝗵 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗰𝗼𝗺𝗽𝘂𝘁𝗲𝗿? This episode explores the fascinating world of virtual patient models and stochastic engineering, unveiling how digital simulations are revolutionising healthcare clinical trials. Discover how simulated trials using sophisticated virtual patient models—complete with variations in age, body size, and disease progression—are introducing groundbreaking innovations in

en

23:19

How can we properly evaluate the true economic impact...

In Silico Trials, Real Impacts! ·

2025/03/31

How are the CHEERS-AI guidelines transforming economic evaluations of healthcare AI? In our latest podcast episode, we delve into how the Consolidated Health Economic Evaluation Reporting Standards for AI (CHEERS-AI) are revolutionizing the economic assessment landscape for artificial intelligence in healthcare. Discover why transparency and consistency are crucial, and how this comprehensive framework helps determine the true financial value of AI innovations in the medical field.This episode

en

17:56

Revolutionising Healthcare: Inside the UK's MHRA Data...

In Silico Trials, Real Impacts! ·

2025/03/24

Will the MHRA's New Data Strategy Transform Healthcare Through Computational Innovation? In this episode, we explore the MHRA's groundbreaking data strategy for 2024-2027, a visionary plan heralding a fourth industrial revolution in healthcare. From supporting data-driven innovation to harnessing AI and real-world evidence, we dive deep into the strategic themes aimed at revolutionizing medical product development and regulation.Learn how AI is set to change the game, enabling quicker development

en

21:58

Unleashing the Potential of Health Data: Insights...

In Silico Trials, Real Impacts! ·

2025/03/17

What is the roadmap to transform how we use health data in the UK? This episode discusses the Sudlow Review and highlights the immense potential of linking health data, tackling accessibility challenges, and the importance of public trust. We discuss its five critical recommendations to make health data a national infrastructure, streamlining access, and ensuring ethical governance across the UK.Whether you're a researcher, policy maker, or simply curious about the future of medical innovation,

en

18:56

Regulatory Frontiers: UK's Centres of Excellence in...

In Silico Trials, Real Impacts! ·

2025/03/10

How is the UK positioning itself at the forefront of regulatory science innovation through strategic investments in centres of excellence? This episode explores the UK Government-funded Centres of Excellence in Regulatory Science and Innovation (CERSI) Initiative and its pivotal role in shaping the future regulatory landscape for AI and in silico technologies in healthcare. We examine two of the seven CERSIs funded by UK Government. Brunel University's critical work on building trust frameworks and

en

40:06

Can NHS Secure Data Environments Unlock the Future of...

In Silico Trials, Real Impacts! ·

2025/03/10

Could NHS Data Environments Revolutionise UK Life Sciences Innovation? This episode focuses on the incredible potential of NHS data in revolutionising medical product development and regulation. The Association of the British Pharmaceutical Industry (ABPI) report, published in February 2025, investigates how to improve the regional Secure Data Environment (SDE) network to better serve the life sciences industry's research needs. The report outlines findings from a consultation with ABPI, ABHI, and

en

22:40

Virtual You vs Cancer: How Digital Twins Are...

In Silico Trials, Real Impacts! ·

2025/03/03

What if your doctor could test hundreds of cancer treatments on a virtual version of your tumour before giving you a single dose of medication? In this episode, we dive into the fascinating concept of digital twins, particularly their application in oncology.Discover how digital twins, virtual replicas of tumours, are being used to simulate treatment scenarios and predict outcomes, offering unprecedented precision in cancer care. Learn about the intricate process of creating these digital twins,

en

45 results

Similar Podcasts

Classic Radio Science Fiction

solgoodmedia.com

Mission to Mars

Inception Point Ai

The 365 Days of Astronomy

365DaysOfAstronomy.org

Creek Devil

william Jevning

UFO Chronicles Podcast

Nik Hunter