In this QCast episode, Jullia and Tom explore the dose expansion phase of phase one oncology trials — the critical bridge between dose finding and proof of concept. They discuss how expansion cohorts confirm safety, explore early efficacy signals, and refine dose and schedule decisions, along with best practices for design, governance, and regulatory alignment that set the stage for a successful phase two. Key TakeawaysTreat the dose expansion phase as a structured bridge between dose finding and

Disrupting the astrocyte-neuronal dynamic in mice destabilizes their memory of fear conditioning.

Send us a text Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recent phase 2 trial looking at the effects of once-weekly semaglutide on alcohol consumption and craving in adults with alcohol use disorder (AUD). Here we go! Once-Weekly Semaglutide in Adults With Alcohol Use Disorder (0:00 – 10:28).Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods

Denise Grassick-Munro, narrates her blog written for the Dementia Researcher website. Carers’ lived experience provides unique insights that help shape dementia research and ensure studies stay relevant to real life. Denise Grassick-Munro explores how carers contribute through Patient and Public Involvement and Engagement (PPIE), supporting everything from clinical trials to co-designing resources. Their expertise enhances understanding, communication, and impact, bridging the gap between

Listen to Andrew Duckworth and Fares Haddad discuss the International Hip Society Supplements published in The Bone & Joint Journal and Bone & Joint Open in May and June 2025. Read the full collection here. Find out as soon as the next episode is live by following us on X (Twitter), Instagram, LinkedIn, Tik Tok or Facebook!

A protective screen of spurious transcriptional activity enables each olfactory neuron to express exactly one out of hundreds of olfactory receptors.

Some scientific discoveries take place in a lab. Others are made deep in the rainforest, along the ocean floor or on the dark side of the moon. And still others are made squelching through mud and ice on the northernmost island on Earth… at least, if you’re NPR climate correspondent Alejandra Borunda. Two summers ago, Alejandra followed an expedition of scientists to Greenland’s Inuit Qeqertaat, or Kaffeeklubben (“Coffee Club”) Island. The researchers with her were aiming to find what plants grew at

Text the Show and Show some LOVE for TR! Sophia & Lilith: Balancing Wisdom and Courage in the Divine Feminine In this transformative episode of the TRUTH RESONATES, Evariel delves into the sacred dance between Sophia, the embodiment of divine wisdom, and Lilith, the fierce archetype of rebellion and independence. Many spiritual seekers, especially women, fall into the trap of mistaking codependent endurance for strength, descending into darkness as rescuers rather than conscious gui...

Usually, when two different species mate, it’s a disaster. At least, that’s what scientists had generally thought about hybrids, the offspring of these unions. But some researchers are starting to change their view as they learn of more beneficial hybrid events. The Atlantic science journalist Katie Wu details two of these hybridization examples: one in desert frogs and one in two ancient plants that <> led to the modern potato.Interested in more biology episodes? Email us your question at

Cases are about to spike again.To read the full newsletter, visit optimistsbarn.substack.com. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit optimistsbarn.substack.com

This episode teaches survival in avalanche-prone environments, emphasizing that most avalanches are preventable if warning signs are recognized early. Avalanches often strike without sound or warning, making awareness and preparation more important than strength or speed.Listeners are encouraged to avoid danger before it starts by identifying risky slopes — typically between 30 to 45 degrees, especially when fresh powder sits atop hard ice. Sounds like a deep whumpf beneath the feet signal

Ever wondered about life with Crohn's disease? Join us as we speak with social media influencer Paula Sojo (@paulasojoro). She shares her personal journey and insights.Topics Covered: Intro Describe Your Journey with Crohn’s Disease Paula discusses her personal experience living with Crohn’s disease. Why do you think this condition is so often misdiagnosed? We explore the challenges in diagnosing Crohn’s disease. How do you mentally cope with Crohn’s disease? Mental strategies and tips for dealing

Creepy crawly season is upon us, Short Wavers! We're welcoming fall with a contemplation of fear and anxiety. In human history, fear kept us safe. It helped us flee from predators. Anxiety made us wary of potential dangers — like venturing into a known lion-infested area. But what happens when these feelings get out of hand in humans today? And why do some of us crave that feeling from scary movies or haunted houses?For answers, we talk to Arash Javanbakht, a psychiatrist from Wayne State

In this special episode of The Dairy Health Blackbelt Podcast, emphasizing the importance of sustainability in dairy production, Dr. Ermias Kebreab from the University of California explains the science behind methane emissions in dairy cattle and the strategies being developed to reduce them. He discusses how inhibitors and feed additives such as seaweed and 3-NOP work, their impact on animal productivity, and the potential benefits for climate change. Listen now on all major platforms!"In

During the Phenology Report for the week of Oct. 7, Staff Phenologist John Latimer covers the next month in nature, development of fall colors, and migratory dragonflies.

Let me try to describe the locations, functions and innervation of the major muscles of the shoulder joint: pectoralis major, latissimus dorsi, serratus anterior, deltoid, trapezius and the rhomboids.

GLP-1 drugs like Ozempic, Wegovy, and Mounjaro have become a cultural phenomenon, transforming appetite regulation and weight loss like nothing before. But with their rise comes a flood of imitators, from flashy “GLP-1 patches” to supplements like Calocurb, all promising the same results without the needles or prescriptions. In this episode, I break down what GLP-1 actually is, how these drugs work, and why they’re so effective—not just for weight but also for cardiovascular outcomes. Then

Acadia Pharmaceuticals’ CEO Catherine Owen Adams discusses the current climate in R&D and details her leadership style.

Today on From Lab To Launch, we’re excited to welcome Dr. Terrance Govender, the VP of Medical Affairs at ClinIntell. ClinIntell, based in Tampa, Florida, supports healthcare executives and leaders in accurately capturing the true severity of their inpatient population using population-based predictive analytics. The results for their customers? More accurate, trustworthy performance data and clinical condition reporting, that can be easily shared and used to drive continuous improvemen...