In this must-listen episode for pharma marketers and corporate counsel, we break down the recent $14.25M False Claims Act settlement involving Diopsys, a neurodiagnostic company accused of offering free tech to physicians—tech that allegedly led to medically unnecessary tests billed to Medicare and Medicaid. This wasn’t just bad billing—it was a marketing strategy gone wrong. The DOJ saw it as a kickback scheme, and the case highlights how well-meaning “value-add” services can turn into legal...

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim sits down with Meraj Khan, founder of DigiBiomics, to explore how his startup is tackling one of healthcare’s biggest gaps: early and accessible diagnosis of lung disease. Meraj explains how DigiBiomics uses AI-driven analysis of cough sounds, breathing patterns, and respiratory data to deliver real-time remote lung health assessments—enabling

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们来关注发表在Neurology(影响因子7.7)上的重要研究"What Are the Proposed Mechanisms Contributing to the Manifestations of Anti-NMDAR Encephalitis?"。这项研究揭示了抗NMDAR脑炎的发病机制，发现自身抗体会导致NMDAR受体被内化，减少突触和突触外NMDAR密度，从而干扰兴奋-抑制性突触平衡。这一发现不仅解释了患者为何出现记忆障碍、精神症状和癫痫等多样临床表现，还为开发靶向治疗策略提供了重要依据，可能改善这一严重自身免疫性脑病的治疗效果。

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YouTube Link Staph Scalded Skin Syndrome presents with terrifying skin desquamation but typically heals without scarring within two weeks. This case demonstrates the classic presentation in a three-year-old child with recent URI, highlighting the typical appearance, clinical course, and management principles. • Staph Scalded Skin Syndrome results from staphylococcal toxins that cleave the epidermis • Most common in young children, often following upper respiratory infections • No mucosal inv...

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。欢迎收听今天的医学前沿！我们关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要研究："Programmable metal-based immuno-photocatalytic nanoparticles for precision activation of anti-tumor immunity."这项突破性研究开发了可编程金属基免疫光催化纳米颗粒，能够通过整合光疗和免疫调节，时空精准激活抗肿瘤免疫反应。这些纳米颗粒不仅能刺激免疫原性细胞死亡并释放肿瘤抗原，还能共同递送免疫检查点抑制剂和佐剂，重塑肿瘤微环境。临床前模型显示，它们能有效抑制肿瘤、激活免疫并预防转移，且全身毒性极低。这项技术为克服免疫抵抗肿瘤的治疗障碍提供了新思路，有望实现高度个性化的癌症免疫治疗！

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★毎週土曜日、夜10：30に配信！ ★「#ドリームハート 」の番外編番組 「#茂木健一郎のポジティブ脳教室 」 リスナーの皆様から寄せられたお悩みやご質問に 茂木健一郎さんが #脳科学 的にお答えし「ポジティブな考え方」を伝授していきます！ 今夜は 神奈川県の「ラジオネーム 音が友だち」さんからのメッセージ。 =========================================== 茂木さん こんばんは。 私は 以前 ノイズキャンセリングイヤホンを使ってみたら 音が無い状態が不安で 心臓の音まで気になってしまいました。 私は何か作業する時も テレビやラジオを小さくつけっぱなしにしておくと 人がいる気配で落ち着き 作業効率が上がります。 これは脳のどういった働きなのでしょうか…？ =========================================== 今週は こちらのご質問にお答えしていきます。 茂木さんに聞いて欲しい疑問・質問、お悩みやご相談など… 全てのメッセージは 毎週土曜日の夜10時から 全国38局で放送している

科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要研究："Programmable metal-based immuno-photocatalytic nanoparticles for precision activation of anti-tumor immunity"。这项突破性研究开发了一种新型纳米平台，通过整合光疗与免疫调节，时空特异性地激活抗肿瘤免疫。这些智能纳米颗粒能产生活性氧，刺激免疫原性细胞死亡，同时递送免疫检查点抑制剂和佐剂，重塑肿瘤微环境。临床前模型显示它们显著抑制肿瘤生长，激活免疫系统并预防转移，且全身毒性极低。这项技术为治疗免疫抵抗性肿瘤提供了全新思路，有望实现精准、微创的个性化癌症免疫治疗，代表了纳米医学在肿瘤治疗领域的重大进展。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Pharmacological research》(IF:9.1)上的重要研究"Vascular endothelial cells and angiogenesis"。该研究深入解析了血管内皮细胞在生理和病理状态下的分裂机制，揭示了肿瘤生长依赖血管生成的关键过程。论文详细阐述了VEGF家族、Semaphorins、Angiopoietins和Ephrins等多重信号通路在血管生成中的复杂调控网络。特别重要的是，研究强调了靶向血管生成信号作为癌症治疗策略的潜力，并介绍了Ponatinib等FDA批准的血管生成抑制剂在多种恶性肿瘤中的应用。此外，研究还指出异常血管生成与糖尿病视网膜病变和年龄相关性黄斑变性等疾病密切相关，为这些疾病的治疗提供了新思路。

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在Journal of nanobiotechnology(影响因子10.6)上的重要论文"Lipid-based nanoparticles external triggered release strategies in cancer nanomedicine"。研究指出，近半数人一生中将患癌症，而传统化疗药物面临递送挑战——不到0.1%的药物能到达肿瘤部位。脂质基纳米颗粒(LBNPs)虽能延长药物循环时间并利用EPR效应，但过于稳定的特性限制了药效释放。本文综述了热、超声、辐射、磁和光等外部触发策略的最新进展，这些技术可实现肿瘤部位的精准药物释放，大幅提高治疗效果并减少副作用，为癌症纳米医学开辟了新路径。

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科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。欢迎收听今天的医学播客！我们关注发表在《American Journal of Obstetrics and Gynecology》(影响因子8.7)上的重要研究：《Assessment of Probiotic and Prebiotic Use in Gynecologic Cancer Patients: A Systematic Review》。 这项系统评价分析了9项随机对照试验，发现益生菌补充剂显著降低了妇科癌症患者放疗引起的腹泻发生率和严重程度，改善了大便一致性，并减少了止泻药的使用。相比之下，单独使用益生元效果有限。研究还发现益生菌可能加速肠道恢复并减少术后并发症。尽管如此，目前尚缺乏益生菌对化疗、免疫治疗及生存率影响的数据。这项研究为妇科癌症患者的辅助治疗提供了重要参考，但未来需要更多标准化菌株的试验来优化临床应用。

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim chats with Raj Piri from Argonaut Manufacturing Services, a contract manufacturing organization specializing in fill-finish services. Raj shares insights about their cross-border operations between Toronto and California, the evolving biotech clients they serve, and how BIO has been a vital networking hub for him over the past 20 years.Recorded live

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim chats with Steve Kaiser from Northern RNA, Calgary’s full-service mRNA manufacturer and developer. Learn how Northern RNA is driving innovation by producing mRNA constructs from digital sequences, working with key Canadian clients like Capitopia and Providence, and planning to expand their team and impact in the mRNA therapeutic space over the next

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim sits down with Dan Salvo from Omnibio, a cutting-edge organization based in Hamilton, Ontario. Discover how Omnibio is pioneering the future of CAR-T manufacturing with their Intelligent Factory — integrating AI and robotics to scale up autologous therapies, improve efficiency, and reduce costs across the biotech value chain. Dan also shares insights

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim sits down with Rob Stoddard from Bio Alberta to discuss Alberta’s strong presence at BIO, highlighting their delegation of 20 companies showcasing cutting-edge technology, commercialization, and research excellence. They explore Alberta’s ambitions to lead Canada in clinical trial activity, growth in health tech and diagnostics, and the evolution of

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.This episode features Penny and Sven from Castle, Canada’s bio manufacturing training partner. Discover how Castle’s hands-on, simulated manufacturing facilities in Charlottetown, Montreal, and near Vancouver are upskilling and reskilling Canada’s bio manufacturing workforce to meet industry demands. They share insights on accelerating workforce training and supporting

Join Jim as he hits the road with NGBiOnTheRoad, capturing exclusive conversations with trailblazers at BIO2025 in Boston.In this episode, Jim talks with Nigel Walker, celebrating his 25th year at BIO. Nigel shares insights on their life sciences agency’s unique focus on branding, publishing, research, and investment services for CDMOs, CROs, and CSOs. Discover how they support companies in angel investment rounds with funding and marketing expertise, their interest in advanced technologies