科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。今天我们要分享发表在影响因子高达8.6的《European journal of nuclear medicine and molecular imaging》上的重要研究："Hybrid Tau-PET/MRI study: Quantitative susceptibility mapping in progressive supranuclear palsy and its correlation with Tau-PET"。这项突破性研究发现，通过结合tau-PET和定量磁化率映射(QSM)技术，能够更早地诊断进行性核上性麻痹(PSP)，这种疾病常被误诊。研究首次揭示了PSP患者特定脑区域铁积累的独特模式，并证实了铁与tau蛋白病理变化之间存在显著关联。这一发现为开发新型诊断生物标志物开辟了新途径，有望改变PSP的临床诊断和治疗前景。

Summary In this conversation, Jenny Chen explores the complex implications of ChatGPT on intelligence and education. She emphasizes the need for careful consideration of the technology's impact, particularly in academic settings, and discusses the broader context of a technological revolution that may have both positive and negative consequences. Takeaways Is ChatGPT making us dumb?This is a much more complicated question.ChatGPT is problematic, especially for students.We should consider...

This is a free preview of a paid episode. To hear more, visit www.razibkhan.comToday Razib talks to Ed West, a British journalist and author. He has served as deputy editor of UnHerd and The Catholic Herald, and has written columns for The Spectator and The Daily Telegraph. He runs the Substack newsletter Wrong Side of History, where he explores culture, politics, and the longue durée of Western history. West is the author of books including Small Men on the Wrong Side of History and The Diversity

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科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Cancer letters》(影响因子9.1)上的重要研究："Obese adipose tissue-derived extracellular vesicles enriched with glycolytic cargo promote colorectal cancer tumorigenesis." 这项突破性研究揭示了肥胖如何通过脂肪细胞释放的细胞外囊泡促进结直肠癌发展。科学家发现，肥胖患者脂肪组织释放的囊泡富含糖酵解酶，这些"分子信使"进入癌细胞后，不仅增强糖酵解活性，还提高癌细胞干性，加速肿瘤生长。更令人惊讶的是，通过阻断特定蛋白，研究人员成功阻断了这一过程，为肥胖相关结直肠癌提供了全新治疗靶点。这一发现不仅阐明了肥胖与癌症之间的分子联系，也为开发针对性疗法开辟了新途径。

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The 11th annual Raw Science Film Festival took place this past weekend in New York City. We were lucky enough to be invited and had the honor of interviewing Dr. Larry Corey in-person. He is a renowned expert in virology, immunology and vaccine development who was featured throughout the film “Ending HIV: The Journey to a Vaccine”. The film won the Jury Award for Best Professional Documentary Feature at the festival. While at the festival our host/producer Kira Dineen accepted the Backstage Best

Happy Halloween, Short Wavers! In today’s news round-up, we’ve got only treats. Hosts Regina Barber and Emily Kwong fill in NPR’s Ailsa Chang on a debate in spider web architecture, how the details shared in storytelling affect how you form memories and why more pixels may not translate to a better TV viewing experience.Have a science question? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at

In this episode of the Talking Biotech podcast, Dr. Kevin Folta and Dr. Zack Abbott discuss the critical role of dietary fiber in human health, the alarming statistics regarding fiber deficiency in the population, and the innovative solutions being developed by Zbiotics to address this issue. They delve into the science behind genetically engineered probiotics that can convert sugars into fiber, enhancing gut health and microbiome diversity. The conversation also touches on future

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在影响因子5.8的《Journal of Medical Internet Research》上的研究"Evaluating Web Retrieval-Assisted Large Language Models With and Without Whitelisting for Evidence-Based Neurology: Comparative Study"。这项神经学领域的重要研究发现，当大型语言模型的网络检索限制在权威神经学网站时，回答准确率显著提升—Sonar模型从60%跃升至78%，专业版模型更达到88-89%。研究证实，使用专业医学来源可使模型表现媲美专业文献检索系统，为临床决策提供可靠支持。这一发现为AI医疗应用的安全边界提供了重要参考，表明简单的内容过滤就能显著提升AI在循证医学中的实用价值。

In a Globe Trotting story Valerie tells Mike what it's like to move "down under" as a Blood Transfusion specialist/blood production manager and Unicorn seller!!

Companies must maintain thorough records to meet FDA inspection requirements, including safety substantiation files, labeling proofs, ingredient documentation, and adverse event logs. Adverse event logs must be retained for six years (three for small businesses), while registration and product listing records require annual updates. Organized, accessible, and up-to-date records are essential not only for compliance but also for growth, due diligence, and investor confidence. Compliance is a s...

How well do we really understand the body? For decades, surgeons have relied on static scans and flat 2D models to plan procedures. Gilly Yildirim believes it’s time to expand our view to more dimensions. As founder and CEO of Vent Creativity, he is bringing together point clouds, digital twins, and physics-based AI to capture movement with a level of precision that static imaging is far from. In conversation with Jenny Chen, Gilly Yildirim describes how his team built a platform that sees t...

Откуда на огромном обелиске взялись следы от совковой лопаты? Куда древнеегипетский мастер, пробивая шурф в граните, ставил пивную кружку? Почему в древнеегипетском карьере нет следов присутствия человека и куда девались отходы производства? Александр Соколов продолжает разбор ролика канала «Протоцивилизация» про Асуанский обелиск.Спикер: Александр Соколов — научный журналист, редактор АНТРОПОГЕНЕЗ.РУ, автор книг «Мифы об эволюции человека», «Ученые скрывают» и «Странная обезьяна». В рубрике

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There’s been a lot of talk about Acetaminophen, also known as Tylenol, in the news – specifically the claim that there is a link between this over-the-counter pain reliever and Autism. In this episode, Dr. Yvette Yatchmink, formerly the clinical director of Developmental Behavioral Pediatrics at Hasbro Children’s Hospital, shares what we know from the data and what it means for pregnant people.

Get Professional High Quality Talk Therapy at BetterHelp. 10% off your first month of therapy with this link - https://betterhelp.com/giantsshoulder (Paid Partnership by BetterHelp)Dr. Camilla Nord is a neuroscientist at Cambridge University and author of The Balanced Brain, a groundbreaking book reframing how we understand mental illness — not as something “in the mind,” but as something deeply rooted in the body.Buy the Balanced Brain: https://amzn.to/4nkWSfRIn this episode, we dive into how

In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging.We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse

If you explore abandoned buildings—as our guest today can attest—be aware that they are not always truly unoccupied, and the "occupier" may be all too human rather than supernatural. Our guest, Wade Lovin from Illinois, learned this lesson in sixth grade when he and his friends ventured into an old mill in their town. What Wade encountered that day profoundly altered his life. A young boy with no prior experience of the paranormal was suddenly thrust into a realm of high strangeness. The veil...

科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Neurology》(影响因子7.7)上的重要文章："Target Trial Emulation: A Primer on Improving Observational Research in Neurology."这项研究探讨了一种创新方法，当随机对照试验因伦理、后勤或财务限制不可行时，如何通过"目标试验模拟"框架提高神经病学观察性研究的质量。研究团队详细介绍了如何模拟理想RCT的各个组件，包括资格标准、干预措施、治疗分配和结果分析，从而减少传统观察性研究中的偏差。这种方法虽无法完全解决数据集限制，但能显著改善研究设计，更精确地定义研究问题，为神经科医生提供更可靠的证据，特别是在RCT难以实施的临床情境中。